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Using graphene-based plasmonic nanocomposites to quench energy from quantum dots for signal-on photoelectrochemical aptasensing.
Anal Chem. 2013 Dec 17; 85(24):11720-4.AC

Abstract

On the basis of the absorption and emission spectra overlap, an enhanced resonance energy transfer caused by excition-plasmon resonance between reduced graphene oxide (RGO)-Au nanoparticles (AuNPs) and CdTe quantum dots (QDs) was obtained. With the synergy of AuNPs and RGO as a planelike energy acceptor, it resulted in the enhancement of energy transfer between excited CdTe QDs and RGO-AuNPs nanocomposites. Upon the novel sandwichlike structure formed via DNA hybridization, the exciton produced in CdTe QDs was annihilated. A damped photocurrent was obtained, which was acted as the background signal for the development of a universal photoelectrochemical (PEC) platform. With the use of carcinoembryonic antigen (CEA) as a model which bonded to its specific aptamer and destroyed the sandwichlike structure, the energy transfer efficiency was lowered, leading to PEC response augment. Thus a signal-on PEC aptasensor was constructed. Under 470 nm irradiation at -0.05 V, the PEC aptasensor for CEA determination exhibited a linear range from 0.001 to 2.0 ng mL(-1) with a detection limit of 0.47 pg mL(-1) at a signal-to-noise ratio of 3 and was satisfactory for clinical sample detection. Since different aptamers can specifically bind to different target molecules, the designed strategy has an expansive application for the construction of versatile PEC platforms.

Authors+Show Affiliations

Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University , Nanjing 210023, P. R. China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24256069

Citation

Zeng, Xianxiang, et al. "Using Graphene-based Plasmonic Nanocomposites to Quench Energy From Quantum Dots for Signal-on Photoelectrochemical Aptasensing." Analytical Chemistry, vol. 85, no. 24, 2013, pp. 11720-4.
Zeng X, Ma S, Bao J, et al. Using graphene-based plasmonic nanocomposites to quench energy from quantum dots for signal-on photoelectrochemical aptasensing. Anal Chem. 2013;85(24):11720-4.
Zeng, X., Ma, S., Bao, J., Tu, W., & Dai, Z. (2013). Using graphene-based plasmonic nanocomposites to quench energy from quantum dots for signal-on photoelectrochemical aptasensing. Analytical Chemistry, 85(24), 11720-4. https://doi.org/10.1021/ac403408y
Zeng X, et al. Using Graphene-based Plasmonic Nanocomposites to Quench Energy From Quantum Dots for Signal-on Photoelectrochemical Aptasensing. Anal Chem. 2013 Dec 17;85(24):11720-4. PubMed PMID: 24256069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Using graphene-based plasmonic nanocomposites to quench energy from quantum dots for signal-on photoelectrochemical aptasensing. AU - Zeng,Xianxiang, AU - Ma,Shishi, AU - Bao,Jianchun, AU - Tu,Wenwen, AU - Dai,Zhihui, Y1 - 2013/11/27/ PY - 2013/11/22/entrez PY - 2013/11/22/pubmed PY - 2014/7/16/medline SP - 11720 EP - 4 JF - Analytical chemistry JO - Anal Chem VL - 85 IS - 24 N2 - On the basis of the absorption and emission spectra overlap, an enhanced resonance energy transfer caused by excition-plasmon resonance between reduced graphene oxide (RGO)-Au nanoparticles (AuNPs) and CdTe quantum dots (QDs) was obtained. With the synergy of AuNPs and RGO as a planelike energy acceptor, it resulted in the enhancement of energy transfer between excited CdTe QDs and RGO-AuNPs nanocomposites. Upon the novel sandwichlike structure formed via DNA hybridization, the exciton produced in CdTe QDs was annihilated. A damped photocurrent was obtained, which was acted as the background signal for the development of a universal photoelectrochemical (PEC) platform. With the use of carcinoembryonic antigen (CEA) as a model which bonded to its specific aptamer and destroyed the sandwichlike structure, the energy transfer efficiency was lowered, leading to PEC response augment. Thus a signal-on PEC aptasensor was constructed. Under 470 nm irradiation at -0.05 V, the PEC aptasensor for CEA determination exhibited a linear range from 0.001 to 2.0 ng mL(-1) with a detection limit of 0.47 pg mL(-1) at a signal-to-noise ratio of 3 and was satisfactory for clinical sample detection. Since different aptamers can specifically bind to different target molecules, the designed strategy has an expansive application for the construction of versatile PEC platforms. SN - 1520-6882 UR - https://www.unboundmedicine.com/medline/citation/24256069/Using_graphene_based_plasmonic_nanocomposites_to_quench_energy_from_quantum_dots_for_signal_on_photoelectrochemical_aptasensing_ L2 - https://doi.org/10.1021/ac403408y DB - PRIME DP - Unbound Medicine ER -