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Closed-loop double-vasopressor automated system vs manual bolus vasopressor to treat hypotension during spinal anaesthesia for caesarean section: a randomised controlled trial.
Anaesthesia 2014; 69(1):37-45A

Abstract

Hypotension necessitating vasopressor administration occurs commonly during caesarean section under spinal anaesthesia. We developed a novel vasopressor delivery system that automatically administers phenylephrine or ephedrine based on continuous non-invasive arterial pressure monitoring. A phenylephrine bolus of 50 μg was given at 30-s intervals when systolic blood pressure fell < 90% of baseline; an ephedrine bolus of 4 mg was given instead if systolic pressure fell < 90% of baseline together with a heart rate < 60 beats.min(-1). The control group used manual boluses of either phenylephrine 100 μg or ephedrine 8 mg, administered at 1-min intervals based on the same thresholds for systolic pressure and heart rate. This randomised, controlled, double-blinded trial involved 213 healthy women who underwent elective caesarean delivery under spinal anaesthesia using 11 mg hyperbaric bupivacaine with 15 μg fentanyl and 100 μg morphine. The automated vasopressor group had better systolic pressure control, with 37/106 (34.9%) having any beat-to-beat systolic pressure reading < 80% of baseline compared with 63/107 (58.9%) in the control group (p < 0.001). There was no difference in the incidence of reactive hypertension, defined as systolic pressure > 120% of baseline, with 8/106 (7.5%) in the automated vasopressor group vs 14/107 (13.1%) in the control group, or total dose of vasopressors. The automated vasopressor group had lower median absolute performance error of 8.5% vs control of 9.8% (p = 0.013), and reduced incidence of nausea (1/106 (0.9%) vs 11/107 (10.3%), p = 0.005). Neonatal umbilical cord pH, umbilical lactate and Apgar scores were similar. Hence, our system afforded better control of maternal blood pressure and reduced nausea with no increase in reactive hypertension when compared with manual boluses.

Authors+Show Affiliations

Department of Women's Anaesthesia, KK Women's and Children's Hospital, Singapore.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24256483

Citation

Sng, B L., et al. "Closed-loop Double-vasopressor Automated System Vs Manual Bolus Vasopressor to Treat Hypotension During Spinal Anaesthesia for Caesarean Section: a Randomised Controlled Trial." Anaesthesia, vol. 69, no. 1, 2014, pp. 37-45.
Sng BL, Tan HS, Sia AT. Closed-loop double-vasopressor automated system vs manual bolus vasopressor to treat hypotension during spinal anaesthesia for caesarean section: a randomised controlled trial. Anaesthesia. 2014;69(1):37-45.
Sng, B. L., Tan, H. S., & Sia, A. T. (2014). Closed-loop double-vasopressor automated system vs manual bolus vasopressor to treat hypotension during spinal anaesthesia for caesarean section: a randomised controlled trial. Anaesthesia, 69(1), pp. 37-45. doi:10.1111/anae.12460.
Sng BL, Tan HS, Sia AT. Closed-loop Double-vasopressor Automated System Vs Manual Bolus Vasopressor to Treat Hypotension During Spinal Anaesthesia for Caesarean Section: a Randomised Controlled Trial. Anaesthesia. 2014;69(1):37-45. PubMed PMID: 24256483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Closed-loop double-vasopressor automated system vs manual bolus vasopressor to treat hypotension during spinal anaesthesia for caesarean section: a randomised controlled trial. AU - Sng,B L, AU - Tan,H S, AU - Sia,A T H, Y1 - 2013/11/20/ PY - 2013/09/06/accepted PY - 2013/11/22/entrez PY - 2013/11/22/pubmed PY - 2014/2/8/medline SP - 37 EP - 45 JF - Anaesthesia JO - Anaesthesia VL - 69 IS - 1 N2 - Hypotension necessitating vasopressor administration occurs commonly during caesarean section under spinal anaesthesia. We developed a novel vasopressor delivery system that automatically administers phenylephrine or ephedrine based on continuous non-invasive arterial pressure monitoring. A phenylephrine bolus of 50 μg was given at 30-s intervals when systolic blood pressure fell < 90% of baseline; an ephedrine bolus of 4 mg was given instead if systolic pressure fell < 90% of baseline together with a heart rate < 60 beats.min(-1). The control group used manual boluses of either phenylephrine 100 μg or ephedrine 8 mg, administered at 1-min intervals based on the same thresholds for systolic pressure and heart rate. This randomised, controlled, double-blinded trial involved 213 healthy women who underwent elective caesarean delivery under spinal anaesthesia using 11 mg hyperbaric bupivacaine with 15 μg fentanyl and 100 μg morphine. The automated vasopressor group had better systolic pressure control, with 37/106 (34.9%) having any beat-to-beat systolic pressure reading < 80% of baseline compared with 63/107 (58.9%) in the control group (p < 0.001). There was no difference in the incidence of reactive hypertension, defined as systolic pressure > 120% of baseline, with 8/106 (7.5%) in the automated vasopressor group vs 14/107 (13.1%) in the control group, or total dose of vasopressors. The automated vasopressor group had lower median absolute performance error of 8.5% vs control of 9.8% (p = 0.013), and reduced incidence of nausea (1/106 (0.9%) vs 11/107 (10.3%), p = 0.005). Neonatal umbilical cord pH, umbilical lactate and Apgar scores were similar. Hence, our system afforded better control of maternal blood pressure and reduced nausea with no increase in reactive hypertension when compared with manual boluses. SN - 1365-2044 UR - https://www.unboundmedicine.com/medline/citation/24256483/Closed_loop_double_vasopressor_automated_system_vs_manual_bolus_vasopressor_to_treat_hypotension_during_spinal_anaesthesia_for_caesarean_section:_a_randomised_controlled_trial_ L2 - https://doi.org/10.1111/anae.12460 DB - PRIME DP - Unbound Medicine ER -