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A nationwide cohort study suggests that hepatitis C virus infection is associated with increased risk of chronic kidney disease.
Kidney Int 2014; 85(5):1200-7KI

Abstract

The association of hepatitis C virus (HCV) infection with chronic kidney disease (CKD) remains widely debated. Here we quantify this association by analysis of data from the Taiwan National Health Insurance Research Database and ICD-9 codes to identify 9430 adults with newly diagnosed HCV (years 1999-2006) and randomly selected 37,720 matched non-HCV control individuals. The incidence rate and risk of incident CKD were evaluated through the end of 2010. The frequency of CKD was 1.66-fold higher in the HCV than the non-HCV cohort (5.46 compared with 3.43 per 1000 person-years), and the adjusted hazard ratio remained significant at 1.28 (95% confidence interval, 1.12-1.46). A multivariate analysis was used to determine the influence of HCV on CKD risk with regard to age, gender, follow-up duration, and comorbidities. The risk for CKD in HCV-infected individuals was higher with diabetes, hyperlipidemia, and cirrhosis (8.44; 3.70-19.23), followed by men<50 years (2.32; 1.49-3.61), all individuals<50 years (1.90; 1.33-2.73), men overall (1.44; 1.22-1.71), and individuals followed for ≥6 years (1.35; 1.06-1.71); all with considerable significance. Thus, HCV infection is associated with an increased risk of CKD. Hence, high-risk HCV-infected individuals should be aggressively monitored for development of CKD.

Authors+Show Affiliations

1] Division of Nephrology, Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan [2] School of Medicine, Tzu Chi University, Hualien, Taiwan.1] School of Medicine, Tzu Chi University, Hualien, Taiwan [2] Department of Radiation Oncology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan.1] Department and Graduate Institute of Public Health, College of Medicine, National Cheng Hung University, Tainan, Taiwan [2] Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.1] School of Medicine, Tzu Chi University, Hualien, Taiwan [2] Department of Radiation Oncology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan.1] School of Medicine, Tzu Chi University, Hualien, Taiwan [2] Division of Hematology-Oncology, Department of Internal Medicine, Buddhist, Dalin Tzu Chi General Hospital, Chiayi, Taiwan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24257691

Citation

Chen, Yi-Chun, et al. "A Nationwide Cohort Study Suggests That Hepatitis C Virus Infection Is Associated With Increased Risk of Chronic Kidney Disease." Kidney International, vol. 85, no. 5, 2014, pp. 1200-7.
Chen YC, Lin HY, Li CY, et al. A nationwide cohort study suggests that hepatitis C virus infection is associated with increased risk of chronic kidney disease. Kidney Int. 2014;85(5):1200-7.
Chen, Y. C., Lin, H. Y., Li, C. Y., Lee, M. S., & Su, Y. C. (2014). A nationwide cohort study suggests that hepatitis C virus infection is associated with increased risk of chronic kidney disease. Kidney International, 85(5), pp. 1200-7. doi:10.1038/ki.2013.455.
Chen YC, et al. A Nationwide Cohort Study Suggests That Hepatitis C Virus Infection Is Associated With Increased Risk of Chronic Kidney Disease. Kidney Int. 2014;85(5):1200-7. PubMed PMID: 24257691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A nationwide cohort study suggests that hepatitis C virus infection is associated with increased risk of chronic kidney disease. AU - Chen,Yi-Chun, AU - Lin,Hon-Yi, AU - Li,Chung-Yi, AU - Lee,Moon-Sing, AU - Su,Yu-Chieh, Y1 - 2013/11/20/ PY - 2013/04/15/received PY - 2013/08/19/revised PY - 2013/08/29/accepted PY - 2013/11/22/entrez PY - 2013/11/22/pubmed PY - 2015/2/11/medline SP - 1200 EP - 7 JF - Kidney international JO - Kidney Int. VL - 85 IS - 5 N2 - The association of hepatitis C virus (HCV) infection with chronic kidney disease (CKD) remains widely debated. Here we quantify this association by analysis of data from the Taiwan National Health Insurance Research Database and ICD-9 codes to identify 9430 adults with newly diagnosed HCV (years 1999-2006) and randomly selected 37,720 matched non-HCV control individuals. The incidence rate and risk of incident CKD were evaluated through the end of 2010. The frequency of CKD was 1.66-fold higher in the HCV than the non-HCV cohort (5.46 compared with 3.43 per 1000 person-years), and the adjusted hazard ratio remained significant at 1.28 (95% confidence interval, 1.12-1.46). A multivariate analysis was used to determine the influence of HCV on CKD risk with regard to age, gender, follow-up duration, and comorbidities. The risk for CKD in HCV-infected individuals was higher with diabetes, hyperlipidemia, and cirrhosis (8.44; 3.70-19.23), followed by men<50 years (2.32; 1.49-3.61), all individuals<50 years (1.90; 1.33-2.73), men overall (1.44; 1.22-1.71), and individuals followed for ≥6 years (1.35; 1.06-1.71); all with considerable significance. Thus, HCV infection is associated with an increased risk of CKD. Hence, high-risk HCV-infected individuals should be aggressively monitored for development of CKD. SN - 1523-1755 UR - https://www.unboundmedicine.com/medline/citation/24257691/A_nationwide_cohort_study_suggests_that_hepatitis_C_virus_infection_is_associated_with_increased_risk_of_chronic_kidney_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0085-2538(15)56320-5 DB - PRIME DP - Unbound Medicine ER -