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Macular cone abnormalities in retinitis pigmentosa with preserved central vision using adaptive optics scanning laser ophthalmoscopy.
PLoS One. 2013; 8(11):e79447.Plos

Abstract

PURPOSE

To assess macular photoreceptor abnormalities in eyes with retinitis pigmentosa (RP) with preserved central vision using adaptive optics scanning laser ophthalmoscopy (AO-SLO).

METHODS

Fourteen eyes of 14 patients with RP (best-corrected visual acuity 20/20 or better) and 12 eyes of 12 volunteers underwent a full ophthalmologic examination, fundus autofluorescence, spectral-domain optical coherence tomography (SD-OCT), and imaging with a prototype AO-SLO system. Cone density and spatial organization of the cone mosaic were assessed using AO-SLO images.

RESULTS

In 3 eyes with RP and preserved central vision, cones formed a mostly regular mosaic pattern with small patchy dark areas, and in 10 eyes, the cone mosaic patterns were less regular, and large dark regions with missing cones were apparent. Only one eye with RP demonstrated a normal, regular cone mosaic pattern. In eyes with RP, cone density was significantly lower at 0.5 mm and 1.0 mm from the center of the fovea compared to normal eyes (P<0.001 and 0.021, respectively). At 0.5 mm and 1.0 mm from the center of the fovea, a decreased number of cones had 6 neighbors in eyes with RP (P = 0.002 for both). Greater decrease in cone density was related to disruption of the photoreceptor inner segment (IS) ellipsoid band on SD-OCT images (P = 0.044); however, dark regions were seen on AO-SLO even in areas of continuous IS ellipsoid on SD-OCT. Decreased cone density correlated thinner outer nuclear layer (P = 0.029) and thinner inner segment and outer segment thickness (P = 0.011) on SD-OCT.

CONCLUSIONS

Cone density is decreased and the regularity of the cone mosaic spatial arrangement is disrupted in eyes with RP, even when visual acuity and foveal sensitivity are good. AO-SLO imaging is a sensitive quantitative tool for detecting photoreceptor abnormalities in eyes with RP.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24260224

Citation

Makiyama, Yukiko, et al. "Macular Cone Abnormalities in Retinitis Pigmentosa With Preserved Central Vision Using Adaptive Optics Scanning Laser Ophthalmoscopy." PloS One, vol. 8, no. 11, 2013, pp. e79447.
Makiyama Y, Ooto S, Hangai M, et al. Macular cone abnormalities in retinitis pigmentosa with preserved central vision using adaptive optics scanning laser ophthalmoscopy. PLoS ONE. 2013;8(11):e79447.
Makiyama, Y., Ooto, S., Hangai, M., Takayama, K., Uji, A., Oishi, A., Ogino, K., Nakagawa, S., & Yoshimura, N. (2013). Macular cone abnormalities in retinitis pigmentosa with preserved central vision using adaptive optics scanning laser ophthalmoscopy. PloS One, 8(11), e79447. https://doi.org/10.1371/journal.pone.0079447
Makiyama Y, et al. Macular Cone Abnormalities in Retinitis Pigmentosa With Preserved Central Vision Using Adaptive Optics Scanning Laser Ophthalmoscopy. PLoS ONE. 2013;8(11):e79447. PubMed PMID: 24260224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macular cone abnormalities in retinitis pigmentosa with preserved central vision using adaptive optics scanning laser ophthalmoscopy. AU - Makiyama,Yukiko, AU - Ooto,Sotaro, AU - Hangai,Masanori, AU - Takayama,Kohei, AU - Uji,Akihito, AU - Oishi,Akio, AU - Ogino,Ken, AU - Nakagawa,Satoko, AU - Yoshimura,Nagahisa, Y1 - 2013/11/19/ PY - 2013/04/18/received PY - 2013/09/23/accepted PY - 2013/11/22/entrez PY - 2013/11/22/pubmed PY - 2014/7/12/medline SP - e79447 EP - e79447 JF - PloS one JO - PLoS ONE VL - 8 IS - 11 N2 - PURPOSE: To assess macular photoreceptor abnormalities in eyes with retinitis pigmentosa (RP) with preserved central vision using adaptive optics scanning laser ophthalmoscopy (AO-SLO). METHODS: Fourteen eyes of 14 patients with RP (best-corrected visual acuity 20/20 or better) and 12 eyes of 12 volunteers underwent a full ophthalmologic examination, fundus autofluorescence, spectral-domain optical coherence tomography (SD-OCT), and imaging with a prototype AO-SLO system. Cone density and spatial organization of the cone mosaic were assessed using AO-SLO images. RESULTS: In 3 eyes with RP and preserved central vision, cones formed a mostly regular mosaic pattern with small patchy dark areas, and in 10 eyes, the cone mosaic patterns were less regular, and large dark regions with missing cones were apparent. Only one eye with RP demonstrated a normal, regular cone mosaic pattern. In eyes with RP, cone density was significantly lower at 0.5 mm and 1.0 mm from the center of the fovea compared to normal eyes (P<0.001 and 0.021, respectively). At 0.5 mm and 1.0 mm from the center of the fovea, a decreased number of cones had 6 neighbors in eyes with RP (P = 0.002 for both). Greater decrease in cone density was related to disruption of the photoreceptor inner segment (IS) ellipsoid band on SD-OCT images (P = 0.044); however, dark regions were seen on AO-SLO even in areas of continuous IS ellipsoid on SD-OCT. Decreased cone density correlated thinner outer nuclear layer (P = 0.029) and thinner inner segment and outer segment thickness (P = 0.011) on SD-OCT. CONCLUSIONS: Cone density is decreased and the regularity of the cone mosaic spatial arrangement is disrupted in eyes with RP, even when visual acuity and foveal sensitivity are good. AO-SLO imaging is a sensitive quantitative tool for detecting photoreceptor abnormalities in eyes with RP. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24260224/Macular_cone_abnormalities_in_retinitis_pigmentosa_with_preserved_central_vision_using_adaptive_optics_scanning_laser_ophthalmoscopy_ L2 - http://dx.plos.org/10.1371/journal.pone.0079447 DB - PRIME DP - Unbound Medicine ER -