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Vitamin D status and community-acquired pneumonia: results from the third National Health and Nutrition Examination Survey.
PLoS One. 2013; 8(11):e81120.Plos

Abstract

OBJECTIVE

To investigate the association between serum 25-hydroxyvitamin D [25(OH)D] level and history of community-acquired pneumonia (CAP).

PATIENTS AND METHODS

We identified 16,975 individuals (≥17 years) from the third National Health and Nutrition Examination Survey (NHANES III) with documented 25(OH)D levels. To investigate the association of 25(OH)D with history of CAP in these participants, we developed a multivariable logistic regression model, adjusting for demographic factors (age, sex, race, poverty-to-income ratio, and geographic location), clinical data (body mass index, smoking status, asthma, chronic obstructive pulmonary disease, congestive heart failure, diabetes mellitus, stroke, chronic kidney disease, neutropenia, and alcohol consumption), and season. Locally weighted scatterplot smoothing (LOWESS) was used to depict the relationship between increasing 25(OH)D levels and the cumulative frequency of CAP in the study cohort.

RESULTS

The median [interquartile range (IQR)] serum 25(OH)D level was 24 (IQR 18-32) ng/mL. 2.1% [95% confidence interval (CI): 1.9-2.3] of participants reported experiencing a CAP within one year of their participation in the national survey. After adjusting for demographic factors, clinical data, and season, 25(OH)D levels <30 ng/mL were associated with 56% higher odds of CAP [odds ratio 1.56; 95% confidence interval: 1.17-2.07] compared to levels ≥30 ng/mL. LOWESS analysis revealed a near linear relationship between vitamin D status and the cumulative frequency of CAP up to 25(OH)D levels around 30 ng/mL.

CONCLUSION

Among 16,975 participants in NHANES III, 25(OH)D levels were inversely associated with history of CAP. Randomized controlled trials are warranted to determine the effect of optimizing vitamin D status on the risk of CAP.

Authors+Show Affiliations

Harvard Medical School, Boston, Massachusetts, United States of America ; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24260547

Citation

Quraishi, Sadeq A., et al. "Vitamin D Status and Community-acquired Pneumonia: Results From the Third National Health and Nutrition Examination Survey." PloS One, vol. 8, no. 11, 2013, pp. e81120.
Quraishi SA, Bittner EA, Christopher KB, et al. Vitamin D status and community-acquired pneumonia: results from the third National Health and Nutrition Examination Survey. PLoS One. 2013;8(11):e81120.
Quraishi, S. A., Bittner, E. A., Christopher, K. B., & Camargo, C. A. (2013). Vitamin D status and community-acquired pneumonia: results from the third National Health and Nutrition Examination Survey. PloS One, 8(11), e81120. https://doi.org/10.1371/journal.pone.0081120
Quraishi SA, et al. Vitamin D Status and Community-acquired Pneumonia: Results From the Third National Health and Nutrition Examination Survey. PLoS One. 2013;8(11):e81120. PubMed PMID: 24260547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D status and community-acquired pneumonia: results from the third National Health and Nutrition Examination Survey. AU - Quraishi,Sadeq A, AU - Bittner,Edward A, AU - Christopher,Kenneth B, AU - Camargo,Carlos A,Jr Y1 - 2013/11/15/ PY - 2013/07/25/received PY - 2013/10/18/accepted PY - 2013/11/22/entrez PY - 2013/11/22/pubmed PY - 2014/7/1/medline SP - e81120 EP - e81120 JF - PloS one JO - PLoS One VL - 8 IS - 11 N2 - OBJECTIVE: To investigate the association between serum 25-hydroxyvitamin D [25(OH)D] level and history of community-acquired pneumonia (CAP). PATIENTS AND METHODS: We identified 16,975 individuals (≥17 years) from the third National Health and Nutrition Examination Survey (NHANES III) with documented 25(OH)D levels. To investigate the association of 25(OH)D with history of CAP in these participants, we developed a multivariable logistic regression model, adjusting for demographic factors (age, sex, race, poverty-to-income ratio, and geographic location), clinical data (body mass index, smoking status, asthma, chronic obstructive pulmonary disease, congestive heart failure, diabetes mellitus, stroke, chronic kidney disease, neutropenia, and alcohol consumption), and season. Locally weighted scatterplot smoothing (LOWESS) was used to depict the relationship between increasing 25(OH)D levels and the cumulative frequency of CAP in the study cohort. RESULTS: The median [interquartile range (IQR)] serum 25(OH)D level was 24 (IQR 18-32) ng/mL. 2.1% [95% confidence interval (CI): 1.9-2.3] of participants reported experiencing a CAP within one year of their participation in the national survey. After adjusting for demographic factors, clinical data, and season, 25(OH)D levels <30 ng/mL were associated with 56% higher odds of CAP [odds ratio 1.56; 95% confidence interval: 1.17-2.07] compared to levels ≥30 ng/mL. LOWESS analysis revealed a near linear relationship between vitamin D status and the cumulative frequency of CAP up to 25(OH)D levels around 30 ng/mL. CONCLUSION: Among 16,975 participants in NHANES III, 25(OH)D levels were inversely associated with history of CAP. Randomized controlled trials are warranted to determine the effect of optimizing vitamin D status on the risk of CAP. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24260547/Vitamin_D_status_and_community_acquired_pneumonia:_results_from_the_third_National_Health_and_Nutrition_Examination_Survey_ L2 - https://dx.plos.org/10.1371/journal.pone.0081120 DB - PRIME DP - Unbound Medicine ER -