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Perinatal risk factors for wheezing phenotypes in the first 8 years of life.
Clin Exp Allergy. 2013 Dec; 43(12):1395-405.CE

Abstract

BACKGROUND

A novel data-driven approach was used to identify wheezing phenotypes in pre-schoolchildren aged 0-8 years, in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort. Five phenotypes were identified: never/infrequent wheeze, transient early wheeze, intermediate onset wheeze, persistent wheeze and late onset wheeze. It is unknown which perinatal risk factors drive development of these phenotypes.

OBJECTIVE

The objective of the study was to assess associations of perinatal factors with wheezing phenotypes and to identify possible targets for prevention.

METHODS

In the PIAMA study (n = 3963), perinatal factors were collected at 3 months, and wheezing was assessed annually until the age of 8 years. Associations between perinatal risk factors and the five wheezing phenotypes were assessed using weighted multinomial logistic regression models. Odds ratios were adjusted for confounding variables and calculated with 'never/infrequent wheeze' as reference category.

RESULTS

Complete data were available for 2728 children. Risk factors for transient early wheeze (n = 455) were male gender, maternal and paternal allergy, low maternal age, high maternal body mass index, short pregnancy duration, smoking during pregnancy, presence of older siblings and day-care attendance. Risk factors for persistent wheeze (n = 83) were male gender, maternal and paternal allergy, and not receiving breastfeeding for at least 12 weeks. Intermediate onset wheeze (n = 98) was associated with a lower birth weight and late onset wheeze (n = 45) with maternal allergy.

CONCLUSION AND CLINICAL RELEVANCE

We identified different risk factors for specific childhood wheezing phenotypes. Some of these are modifiable, such as maternal age and body mass index, smoking, day-care attendance and breastfeeding, and may be important targets for prevention programmes.

Authors+Show Affiliations

Department of Pediatrics/Respiratory Medicine, Erasmus University Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24261948

Citation

Caudri, D, et al. "Perinatal Risk Factors for Wheezing Phenotypes in the First 8 Years of Life." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 43, no. 12, 2013, pp. 1395-405.
Caudri D, Savenije OE, Smit HA, et al. Perinatal risk factors for wheezing phenotypes in the first 8 years of life. Clin Exp Allergy. 2013;43(12):1395-405.
Caudri, D., Savenije, O. E., Smit, H. A., Postma, D. S., Koppelman, G. H., Wijga, A. H., Kerkhof, M., Gehring, U., Hoekstra, M. O., Brunekreef, B., & de Jongste, J. C. (2013). Perinatal risk factors for wheezing phenotypes in the first 8 years of life. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 43(12), 1395-405. https://doi.org/10.1111/cea.12173
Caudri D, et al. Perinatal Risk Factors for Wheezing Phenotypes in the First 8 Years of Life. Clin Exp Allergy. 2013;43(12):1395-405. PubMed PMID: 24261948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perinatal risk factors for wheezing phenotypes in the first 8 years of life. AU - Caudri,D, AU - Savenije,O E M, AU - Smit,H A, AU - Postma,D S, AU - Koppelman,G H, AU - Wijga,A H, AU - Kerkhof,M, AU - Gehring,U, AU - Hoekstra,M O, AU - Brunekreef,B, AU - de Jongste,J C, PY - 2012/08/21/received PY - 2013/05/24/revised PY - 2013/06/21/accepted PY - 2013/11/23/entrez PY - 2013/11/23/pubmed PY - 2014/7/19/medline KW - childhood asthma KW - latent class analysis KW - prevention KW - risk factors KW - wheezing phenotypes SP - 1395 EP - 405 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin Exp Allergy VL - 43 IS - 12 N2 - BACKGROUND: A novel data-driven approach was used to identify wheezing phenotypes in pre-schoolchildren aged 0-8 years, in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort. Five phenotypes were identified: never/infrequent wheeze, transient early wheeze, intermediate onset wheeze, persistent wheeze and late onset wheeze. It is unknown which perinatal risk factors drive development of these phenotypes. OBJECTIVE: The objective of the study was to assess associations of perinatal factors with wheezing phenotypes and to identify possible targets for prevention. METHODS: In the PIAMA study (n = 3963), perinatal factors were collected at 3 months, and wheezing was assessed annually until the age of 8 years. Associations between perinatal risk factors and the five wheezing phenotypes were assessed using weighted multinomial logistic regression models. Odds ratios were adjusted for confounding variables and calculated with 'never/infrequent wheeze' as reference category. RESULTS: Complete data were available for 2728 children. Risk factors for transient early wheeze (n = 455) were male gender, maternal and paternal allergy, low maternal age, high maternal body mass index, short pregnancy duration, smoking during pregnancy, presence of older siblings and day-care attendance. Risk factors for persistent wheeze (n = 83) were male gender, maternal and paternal allergy, and not receiving breastfeeding for at least 12 weeks. Intermediate onset wheeze (n = 98) was associated with a lower birth weight and late onset wheeze (n = 45) with maternal allergy. CONCLUSION AND CLINICAL RELEVANCE: We identified different risk factors for specific childhood wheezing phenotypes. Some of these are modifiable, such as maternal age and body mass index, smoking, day-care attendance and breastfeeding, and may be important targets for prevention programmes. SN - 1365-2222 UR - https://www.unboundmedicine.com/medline/citation/24261948/Perinatal_risk_factors_for_wheezing_phenotypes_in_the_first_8_years_of_life_ L2 - https://doi.org/10.1111/cea.12173 DB - PRIME DP - Unbound Medicine ER -