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Long-term clinical outcome of sacral chondrosarcoma treated by total en bloc sacrectomy and reconstruction of lumbosacral and pelvic ring using intraoperative extracorporeal irradiated autologous tumor-bearing sacrum: a case report with 10 years follow-up.
Spine J. 2014 May 01; 14(5):e1-8.SJ

Abstract

BACKGROUND CONTEXT

Primary malignant tumors of the sacrum are rare. Chondrosarcoma is one of the common malignant tumors arising from the sacrum. Chondrosarcoma is often invasive, and there is a high propensity for local recurrence. Surgical resection is often the only effective treatment; however, the treatment of malignant sacral tumors can be challenging, both because of the anatomy of the spinopelvic complex and the frequently large tumor size.

PURPOSE

We report a case of sacral chondrosarcoma that was successfully treated by total en bloc sacrectomy and reconstruction of the lumbosacral and pelvic ring using intraoperative extracorporeal irradiated autologous tumor-bearing sacrum.

STUDY DESIGN

A case report with 10 years follow-up.

METHODS

A 51-year-old man presented with right lower leg pain. Plain radiographs and computed tomography (CT) showed an osteolytic lesion at the sacrum that extended to the sacroiliac joint. Magnetic resonance imaging demonstrated that the tumor mass was localized from S1 to S2 with an epidural lesion at L5-S1 disc level. Histopathologic evaluation by open biopsy revealed that the lesion was chondrosarcoma. Total en bloc sacrectomy of the tumor-bearing sacrum was performed. The removed tumor-bearing sacrum was extracorporeally irradiated at 200 Gy during the operation and returned to the original position as a bone graft and fixed with instruments thereafter.

RESULTS

We needed two revision surgeries during the first 3 years because of the implant failures; however, 10 years after the initial surgery, CT revealed that the irradiated sacrum had remodeled into living bone and integrated with surrounding iliac bone without radiological evidence of tumor recurrence. The patient ambulates without any support and there was no clinical and radiological evidence of tumor recurrence.

CONCLUSIONS

The advantages of our method include the availability of high dose of radiation because of extracorporeal irradiation, excellent fit between graft and host bone, reduction of the dead space, no immunological rejection, no need for a bone bank, availability of the sacrum not only for the augmentation of the large defect but also for the scaffold for the other bone grafts. Our report is of only one case; however, we consider that it could be one option for the treatment of sacral malignant bone tumors, such as chondrosarcoma.

Authors+Show Affiliations

Department of Orthopaedic Surgery, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. Electronic address: grotto@belle.shiga-med.ac.jp.Department of Orthopaedic Surgery, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.Department of Orthopaedic Surgery, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.Shiga Spine Center, Hino Memorial Hospital, Hino-cho, Gamou, Shiga 529-1642, Japan.Department of Orthopaedic Surgery, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

24262861

Citation

Nishizawa, Kazuya, et al. "Long-term Clinical Outcome of Sacral Chondrosarcoma Treated By Total En Bloc Sacrectomy and Reconstruction of Lumbosacral and Pelvic Ring Using Intraoperative Extracorporeal Irradiated Autologous Tumor-bearing Sacrum: a Case Report With 10 Years Follow-up." The Spine Journal : Official Journal of the North American Spine Society, vol. 14, no. 5, 2014, pp. e1-8.
Nishizawa K, Mori K, Saruhashi Y, et al. Long-term clinical outcome of sacral chondrosarcoma treated by total en bloc sacrectomy and reconstruction of lumbosacral and pelvic ring using intraoperative extracorporeal irradiated autologous tumor-bearing sacrum: a case report with 10 years follow-up. Spine J. 2014;14(5):e1-8.
Nishizawa, K., Mori, K., Saruhashi, Y., Takahashi, S., & Matsusue, Y. (2014). Long-term clinical outcome of sacral chondrosarcoma treated by total en bloc sacrectomy and reconstruction of lumbosacral and pelvic ring using intraoperative extracorporeal irradiated autologous tumor-bearing sacrum: a case report with 10 years follow-up. The Spine Journal : Official Journal of the North American Spine Society, 14(5), e1-8. https://doi.org/10.1016/j.spinee.2013.10.057
Nishizawa K, et al. Long-term Clinical Outcome of Sacral Chondrosarcoma Treated By Total En Bloc Sacrectomy and Reconstruction of Lumbosacral and Pelvic Ring Using Intraoperative Extracorporeal Irradiated Autologous Tumor-bearing Sacrum: a Case Report With 10 Years Follow-up. Spine J. 2014 May 1;14(5):e1-8. PubMed PMID: 24262861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term clinical outcome of sacral chondrosarcoma treated by total en bloc sacrectomy and reconstruction of lumbosacral and pelvic ring using intraoperative extracorporeal irradiated autologous tumor-bearing sacrum: a case report with 10 years follow-up. AU - Nishizawa,Kazuya, AU - Mori,Kanji, AU - Saruhashi,Yasuo, AU - Takahashi,Shinobu, AU - Matsusue,Yoshitaka, Y1 - 2013/11/19/ PY - 2013/06/14/received PY - 2013/10/22/revised PY - 2013/10/31/accepted PY - 2013/11/23/entrez PY - 2013/11/23/pubmed PY - 2015/5/6/medline KW - Chondrosarcoma KW - Intraoperative extracorporeal irradiation KW - Long-term clinical outcome KW - Reconstruction of lumbosacral and pelvic ring KW - Remodeling into living bone KW - Total en bloc sacrectomy SP - e1 EP - 8 JF - The spine journal : official journal of the North American Spine Society JO - Spine J VL - 14 IS - 5 N2 - BACKGROUND CONTEXT: Primary malignant tumors of the sacrum are rare. Chondrosarcoma is one of the common malignant tumors arising from the sacrum. Chondrosarcoma is often invasive, and there is a high propensity for local recurrence. Surgical resection is often the only effective treatment; however, the treatment of malignant sacral tumors can be challenging, both because of the anatomy of the spinopelvic complex and the frequently large tumor size. PURPOSE: We report a case of sacral chondrosarcoma that was successfully treated by total en bloc sacrectomy and reconstruction of the lumbosacral and pelvic ring using intraoperative extracorporeal irradiated autologous tumor-bearing sacrum. STUDY DESIGN: A case report with 10 years follow-up. METHODS: A 51-year-old man presented with right lower leg pain. Plain radiographs and computed tomography (CT) showed an osteolytic lesion at the sacrum that extended to the sacroiliac joint. Magnetic resonance imaging demonstrated that the tumor mass was localized from S1 to S2 with an epidural lesion at L5-S1 disc level. Histopathologic evaluation by open biopsy revealed that the lesion was chondrosarcoma. Total en bloc sacrectomy of the tumor-bearing sacrum was performed. The removed tumor-bearing sacrum was extracorporeally irradiated at 200 Gy during the operation and returned to the original position as a bone graft and fixed with instruments thereafter. RESULTS: We needed two revision surgeries during the first 3 years because of the implant failures; however, 10 years after the initial surgery, CT revealed that the irradiated sacrum had remodeled into living bone and integrated with surrounding iliac bone without radiological evidence of tumor recurrence. The patient ambulates without any support and there was no clinical and radiological evidence of tumor recurrence. CONCLUSIONS: The advantages of our method include the availability of high dose of radiation because of extracorporeal irradiation, excellent fit between graft and host bone, reduction of the dead space, no immunological rejection, no need for a bone bank, availability of the sacrum not only for the augmentation of the large defect but also for the scaffold for the other bone grafts. Our report is of only one case; however, we consider that it could be one option for the treatment of sacral malignant bone tumors, such as chondrosarcoma. SN - 1878-1632 UR - https://www.unboundmedicine.com/medline/citation/24262861/Long_term_clinical_outcome_of_sacral_chondrosarcoma_treated_by_total_en_bloc_sacrectomy_and_reconstruction_of_lumbosacral_and_pelvic_ring_using_intraoperative_extracorporeal_irradiated_autologous_tumor_bearing_sacrum:_a_case_report_with_10_years_follow_up_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1529-9430(13)01729-4 DB - PRIME DP - Unbound Medicine ER -