Tags

Type your tag names separated by a space and hit enter

Olfactory performance acts as a cognitive reserve in non-demented patients with Parkinson's disease.
Parkinsonism Relat Disord. 2014 Feb; 20(2):186-91.PR

Abstract

OBJECTIVE

To explore whether olfactory performance acts as a cognitive reserve in non-demented patients with Parkinson's disease (PD).

METHODS

Patients with non-demented PD (n = 119) underwent T1-weighted MRI and olfactory identification tests. According to their olfactory performance, PD patients were subdivided into three groups of high score (PD-H, n = 38), middle score (PD-M, n = 48), and low score (PD-L, n = 33). We investigated the pattern of gray matter (GM) density according to olfactory performance using voxel-based morphometry (VBM) and analyzed the correlation between GM density and olfactory performance.

RESULTS

No significant differences in demographic characteristics were observed among the groups. A neuropsychological test showed that cognitive deficits in verbal memory function were more severe in the PD-L group than in the PD-H group. However, a VBM analysis revealed that patients in the PD-H group possessed significantly decreased GM density in the bilateral temporal areas, orbitofrontal areas, mesiofrontal areas extending into the cingulate gyrus, and prefrontal areas, compared with patients in the PD-L group. No areas exhibiting a significant difference in GM density were observed between the PD-H and PD-M groups. Olfactory performance in patients with PD was negatively correlated with both the brain GM volume and intracerebral volume; in particular, GM density in the caudate nucleus and putamen exhibited a negative correlation with olfactory performance.

CONCLUSIONS

Our data show that a high olfactory performance may compensate GM volume loss in order to minimize the exhibition of cognitive impairment and thus may act as a cognitive reserve in non-demented patients with PD.

Authors+Show Affiliations

Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, South Korea.Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, South Korea.Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, South Korea.Department of Neurology, Jeju University College of Medicine, Jeju, South Korea.Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, South Korea.Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, South Korea; Severance Biomedical Science Institute, Seoul, South Korea. Electronic address: phisland@chol.net.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24262869

Citation

Lee, Ji E., et al. "Olfactory Performance Acts as a Cognitive Reserve in Non-demented Patients With Parkinson's Disease." Parkinsonism & Related Disorders, vol. 20, no. 2, 2014, pp. 186-91.
Lee JE, Cho KH, Ham JH, et al. Olfactory performance acts as a cognitive reserve in non-demented patients with Parkinson's disease. Parkinsonism Relat Disord. 2014;20(2):186-91.
Lee, J. E., Cho, K. H., Ham, J. H., Song, S. K., Sohn, Y. H., & Lee, P. H. (2014). Olfactory performance acts as a cognitive reserve in non-demented patients with Parkinson's disease. Parkinsonism & Related Disorders, 20(2), 186-91. https://doi.org/10.1016/j.parkreldis.2013.10.024
Lee JE, et al. Olfactory Performance Acts as a Cognitive Reserve in Non-demented Patients With Parkinson's Disease. Parkinsonism Relat Disord. 2014;20(2):186-91. PubMed PMID: 24262869.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Olfactory performance acts as a cognitive reserve in non-demented patients with Parkinson's disease. AU - Lee,Ji E, AU - Cho,Kyoo H, AU - Ham,Jee Hyun, AU - Song,Sook K, AU - Sohn,Young H, AU - Lee,Phil Hyu, Y1 - 2013/11/04/ PY - 2013/07/30/received PY - 2013/10/23/revised PY - 2013/10/27/accepted PY - 2013/11/23/entrez PY - 2013/11/23/pubmed PY - 2014/9/25/medline KW - Cognitive reserve KW - Olfaction KW - Parkinson's disease KW - Voxel-based morphometry SP - 186 EP - 91 JF - Parkinsonism & related disorders JO - Parkinsonism Relat. Disord. VL - 20 IS - 2 N2 - OBJECTIVE: To explore whether olfactory performance acts as a cognitive reserve in non-demented patients with Parkinson's disease (PD). METHODS: Patients with non-demented PD (n = 119) underwent T1-weighted MRI and olfactory identification tests. According to their olfactory performance, PD patients were subdivided into three groups of high score (PD-H, n = 38), middle score (PD-M, n = 48), and low score (PD-L, n = 33). We investigated the pattern of gray matter (GM) density according to olfactory performance using voxel-based morphometry (VBM) and analyzed the correlation between GM density and olfactory performance. RESULTS: No significant differences in demographic characteristics were observed among the groups. A neuropsychological test showed that cognitive deficits in verbal memory function were more severe in the PD-L group than in the PD-H group. However, a VBM analysis revealed that patients in the PD-H group possessed significantly decreased GM density in the bilateral temporal areas, orbitofrontal areas, mesiofrontal areas extending into the cingulate gyrus, and prefrontal areas, compared with patients in the PD-L group. No areas exhibiting a significant difference in GM density were observed between the PD-H and PD-M groups. Olfactory performance in patients with PD was negatively correlated with both the brain GM volume and intracerebral volume; in particular, GM density in the caudate nucleus and putamen exhibited a negative correlation with olfactory performance. CONCLUSIONS: Our data show that a high olfactory performance may compensate GM volume loss in order to minimize the exhibition of cognitive impairment and thus may act as a cognitive reserve in non-demented patients with PD. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/24262869/Olfactory_performance_acts_as_a_cognitive_reserve_in_non_demented_patients_with_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(13)00387-8 DB - PRIME DP - Unbound Medicine ER -