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Combination of haloperidol, dexamethasone, and ondansetron reduces nausea and pain intensity and morphine consumption after laparoscopic sleeve gastrectomy.
Braz J Anesthesiol. 2013 Sep-Oct; 63(5):404-9.BJ

Abstract

BACKGROUND AND OBJECTIVE

Postoperative nausea and vomiting (PONV) occur frequently after laparoscopic bariatric surgery. The combination of haloperidol, dexamethasone, and ondansetron may reduce these undesirable events. The aim of this study was to evaluate the intensity of nausea and pain, the number of vomiting episodes, and morphine consumption in postoperative (PO) obese patients undergoing laparoscopic sleeve gastrectomy (LSG).

METHOD

A clinical, randomized, controlled, double-blind study conducted with 90 patients with body mass index ≥ 35 kg.cm-2. Patients were divided into three groups of 30 individuals to receive ondansetron 8 mg (Group O); ondansetron 8 mg and dexamethasone 8 mg (Group OD); and ondansetron 8 mg, dexamethasone 8 mg, and haloperidol 2 mg (Group HDO). We evaluated the intensity of nausea and pain using the verbal numeric scale, cumulative number of vomiting episodes, and morphine consumption in the period of 0-2, 2-12, 12-24, and 24-36 hours postoperatively.

RESULTS

Nausea intensity was lower in Group HDO compared to Group O (p = 0.001), pain intensity was lower in Group HDO compared to Group O (p = 0.046), and morphine consumption was lower in Group HDO compared to Group O (p = 0.037). There was no difference between groups regarding the number of vomiting episodes (p = 0.052).

CONCLUSION

The combination of haloperidol, ondansetron, and dexamethasone reduced nausea and pain intensity and morphine consumption in postoperative obese patients undergoing LSG.

Authors+Show Affiliations

Centro de Ensino e Treinamento da Sociedade Brasileira de Anestesiologia, Cuiabá, MT, Brasil. Electronic address: mmmmb@terra.com.br.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

24263044

Citation

Benevides, Márcio Luiz, et al. "Combination of Haloperidol, Dexamethasone, and Ondansetron Reduces Nausea and Pain Intensity and Morphine Consumption After Laparoscopic Sleeve Gastrectomy." Brazilian Journal of Anesthesiology (Elsevier), vol. 63, no. 5, 2013, pp. 404-9.
Benevides ML, Oliveira Sde S, Aguilar-Nascimento JE. Combination of haloperidol, dexamethasone, and ondansetron reduces nausea and pain intensity and morphine consumption after laparoscopic sleeve gastrectomy. Braz J Anesthesiol. 2013;63(5):404-9.
Benevides, M. L., Oliveira, S. d. e. . S., & Aguilar-Nascimento, J. E. (2013). Combination of haloperidol, dexamethasone, and ondansetron reduces nausea and pain intensity and morphine consumption after laparoscopic sleeve gastrectomy. Brazilian Journal of Anesthesiology (Elsevier), 63(5), 404-9. https://doi.org/10.1016/j.bjan.2012.07.011
Benevides ML, Oliveira Sde S, Aguilar-Nascimento JE. Combination of Haloperidol, Dexamethasone, and Ondansetron Reduces Nausea and Pain Intensity and Morphine Consumption After Laparoscopic Sleeve Gastrectomy. Braz J Anesthesiol. 2013 Sep-Oct;63(5):404-9. PubMed PMID: 24263044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combination of haloperidol, dexamethasone, and ondansetron reduces nausea and pain intensity and morphine consumption after laparoscopic sleeve gastrectomy. AU - Benevides,Márcio Luiz, AU - Oliveira,Sérgio de Souza, AU - Aguilar-Nascimento,José Eduardo, PY - 2012/04/15/received PY - 2012/07/30/accepted PY - 2013/11/23/entrez PY - 2013/11/23/pubmed PY - 2015/4/14/medline KW - Antiemético KW - Bariátrica KW - CIRURGIA KW - COMPLICAÇÕES KW - DROGAS KW - Dexametasona KW - Haloperidol KW - Náusea KW - Ondansetron KW - Vômito. SP - 404 EP - 9 JF - Brazilian journal of anesthesiology (Elsevier) JO - Braz J Anesthesiol VL - 63 IS - 5 N2 - BACKGROUND AND OBJECTIVE: Postoperative nausea and vomiting (PONV) occur frequently after laparoscopic bariatric surgery. The combination of haloperidol, dexamethasone, and ondansetron may reduce these undesirable events. The aim of this study was to evaluate the intensity of nausea and pain, the number of vomiting episodes, and morphine consumption in postoperative (PO) obese patients undergoing laparoscopic sleeve gastrectomy (LSG). METHOD: A clinical, randomized, controlled, double-blind study conducted with 90 patients with body mass index ≥ 35 kg.cm-2. Patients were divided into three groups of 30 individuals to receive ondansetron 8 mg (Group O); ondansetron 8 mg and dexamethasone 8 mg (Group OD); and ondansetron 8 mg, dexamethasone 8 mg, and haloperidol 2 mg (Group HDO). We evaluated the intensity of nausea and pain using the verbal numeric scale, cumulative number of vomiting episodes, and morphine consumption in the period of 0-2, 2-12, 12-24, and 24-36 hours postoperatively. RESULTS: Nausea intensity was lower in Group HDO compared to Group O (p = 0.001), pain intensity was lower in Group HDO compared to Group O (p = 0.046), and morphine consumption was lower in Group HDO compared to Group O (p = 0.037). There was no difference between groups regarding the number of vomiting episodes (p = 0.052). CONCLUSION: The combination of haloperidol, ondansetron, and dexamethasone reduced nausea and pain intensity and morphine consumption in postoperative obese patients undergoing LSG. SN - 0104-0014 UR - https://www.unboundmedicine.com/medline/citation/24263044/Combination_of_haloperidol_dexamethasone_and_ondansetron_reduces_nausea_and_pain_intensity_and_morphine_consumption_after_laparoscopic_sleeve_gastrectomy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0034-7094(13)00087-1 DB - PRIME DP - Unbound Medicine ER -