Metal free stereoselective synthesis of functionalized enamides.
Org Biomol Chem. 2014 Jan 14; 12(2):242-6.OB

Abstract

An efficient and expeditious DABCO-mediated synthesis of functionalized enamides from alkenes is delineated. The reaction proceeds through an unprecedented cascade involving an Aza-Michael addition/α-bromination/elimination and a Morita-Baylis-Hillman type reaction to generate functionalized enamides in a regio- & stereoselective fashion.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Lone AM

Medicinal Chemistry Division, Indian Institute of Integrative Medicine, Srinagar, India. bilal@iiim.ac.in.

Bhat BA

No affiliation info available

MeSH

AlkenesAmidesMolecular StructureStereoisomerism

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24264738

Citation

Lone, Ali Mohd, and Bilal Ahmad Bhat. "Metal Free Stereoselective Synthesis of Functionalized Enamides." Organic & Biomolecular Chemistry, vol. 12, no. 2, 2014, pp. 242-6.

Lone AM, Bhat BA. Metal free stereoselective synthesis of functionalized enamides. Org Biomol Chem. 2014;12(2):242-6.

Lone, A. M., & Bhat, B. A. (2014). Metal free stereoselective synthesis of functionalized enamides. Organic & Biomolecular Chemistry, 12(2), 242-6. https://doi.org/10.1039/c3ob41847b

Lone AM, Bhat BA. Metal Free Stereoselective Synthesis of Functionalized Enamides. Org Biomol Chem. 2014 Jan 14;12(2):242-6. PubMed PMID: 24264738.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Metal free stereoselective synthesis of functionalized enamides. AU - Lone,Ali Mohd, AU - Bhat,Bilal Ahmad, PY - 2013/11/23/entrez PY - 2013/11/23/pubmed PY - 2014/10/14/medline SP - 242 EP - 6 JF - Organic & biomolecular chemistry JO - Org Biomol Chem VL - 12 IS - 2 N2 - An efficient and expeditious DABCO-mediated synthesis of functionalized enamides from alkenes is delineated. The reaction proceeds through an unprecedented cascade involving an Aza-Michael addition/α-bromination/elimination and a Morita-Baylis-Hillman type reaction to generate functionalized enamides in a regio- & stereoselective fashion. SN - 1477-0539 UR - https://www.unboundmedicine.com/medline/citation/24264738/Metal_free_stereoselective_synthesis_of_functionalized_enamides_ DB - PRIME DP - Unbound Medicine ER -

Tags

Metal free stereoselective synthesis of functionalized enamides.Org Biomol Chem. 2014 Jan 14; 12(2):242-6.OB