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Association between statin use and colorectal cancer risk: a meta-analysis of 42 studies.
Cancer Causes Control 2014; 25(2):237-49CC

Abstract

PURPOSE

There is a long-standing debate about whether statins have chemopreventive properties against colorectal cancer (CRC), but the results remain inconclusive. We therefore present a meta-analysis to investigate the association between statin use and risk of CRC.

METHODS

A comprehensive literature search was undertaken through July 2013 looking for eligible studies. Pooled relative risk (RR) estimates and 95 % confidence intervals (CIs) were used to calculate estimated effect.

RESULTS

Forty-two studies [18 case-control studies, 13 cohort studies, and 11 randomized controlled trials (RCTs)] were included in this analysis. Overall, statin use was associated with a modest reduction in the risk of CRC (RR = 0.90, 95 % CI 0.86-0.95). When the analyses were stratified into subgroups, a significant decreased association of CRC risk was observed in observational studies (RR = 0.89, 95 % CI 0.84-0.95), rectal cancer (RR = 0.81, 95 % CI 0.66-0.99), and lipophilic statin (RR = 0.88, 95 % CI 0.85-0.93), but not in RCTs (RR = 0.96, 95 % CI 0.85-1.08), colon cancer, and hydrophilic statin. However, long-term statin use (≥5 years) did not significantly affect the risk of CRC (RR = 0.96, 95 % CI 0.90-1.03). Cumulative meta-analysis showed that statin use significantly reduces the risk of CRC, which has been available between 2007 and 2013.

CONCLUSIONS

Our results suggest that statin use is associated with a modest reduced risk of CRC; apparent associations were found for lipophilic statin use. However, long-term statin use did not appear to significantly affect the risk of CRC.

Authors+Show Affiliations

Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

24265089

Citation

Liu, Yanqiong, et al. "Association Between Statin Use and Colorectal Cancer Risk: a Meta-analysis of 42 Studies." Cancer Causes & Control : CCC, vol. 25, no. 2, 2014, pp. 237-49.
Liu Y, Tang W, Wang J, et al. Association between statin use and colorectal cancer risk: a meta-analysis of 42 studies. Cancer Causes Control. 2014;25(2):237-49.
Liu, Y., Tang, W., Wang, J., Xie, L., Li, T., He, Y., ... Qin, X. (2014). Association between statin use and colorectal cancer risk: a meta-analysis of 42 studies. Cancer Causes & Control : CCC, 25(2), pp. 237-49. doi:10.1007/s10552-013-0326-6.
Liu Y, et al. Association Between Statin Use and Colorectal Cancer Risk: a Meta-analysis of 42 Studies. Cancer Causes Control. 2014;25(2):237-49. PubMed PMID: 24265089.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between statin use and colorectal cancer risk: a meta-analysis of 42 studies. AU - Liu,Yanqiong, AU - Tang,Weizhong, AU - Wang,Jian, AU - Xie,Li, AU - Li,Taijie, AU - He,Yu, AU - Deng,Yan, AU - Peng,Qiliu, AU - Li,Shan, AU - Qin,Xue, Y1 - 2013/11/22/ PY - 2013/08/14/received PY - 2013/11/14/accepted PY - 2013/11/23/entrez PY - 2013/11/23/pubmed PY - 2014/10/23/medline SP - 237 EP - 49 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 25 IS - 2 N2 - PURPOSE: There is a long-standing debate about whether statins have chemopreventive properties against colorectal cancer (CRC), but the results remain inconclusive. We therefore present a meta-analysis to investigate the association between statin use and risk of CRC. METHODS: A comprehensive literature search was undertaken through July 2013 looking for eligible studies. Pooled relative risk (RR) estimates and 95 % confidence intervals (CIs) were used to calculate estimated effect. RESULTS: Forty-two studies [18 case-control studies, 13 cohort studies, and 11 randomized controlled trials (RCTs)] were included in this analysis. Overall, statin use was associated with a modest reduction in the risk of CRC (RR = 0.90, 95 % CI 0.86-0.95). When the analyses were stratified into subgroups, a significant decreased association of CRC risk was observed in observational studies (RR = 0.89, 95 % CI 0.84-0.95), rectal cancer (RR = 0.81, 95 % CI 0.66-0.99), and lipophilic statin (RR = 0.88, 95 % CI 0.85-0.93), but not in RCTs (RR = 0.96, 95 % CI 0.85-1.08), colon cancer, and hydrophilic statin. However, long-term statin use (≥5 years) did not significantly affect the risk of CRC (RR = 0.96, 95 % CI 0.90-1.03). Cumulative meta-analysis showed that statin use significantly reduces the risk of CRC, which has been available between 2007 and 2013. CONCLUSIONS: Our results suggest that statin use is associated with a modest reduced risk of CRC; apparent associations were found for lipophilic statin use. However, long-term statin use did not appear to significantly affect the risk of CRC. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/24265089/Association_between_statin_use_and_colorectal_cancer_risk:_a_meta_analysis_of_42_studies_ L2 - https://doi.org/10.1007/s10552-013-0326-6 DB - PRIME DP - Unbound Medicine ER -