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Bone quality and strength are greater in growing male rats fed fructose compared with glucose.
Nutr Res. 2013 Dec; 33(12):1063-71.NR

Abstract

Optimization of peak bone mass during adolescence is important for osteoporosis prevention. Studies in rodents and humans have demonstrated the harmful effects of sugar intake on bone health. With the high levels of sucrose in the diets of adolescents, it is necessary to understand the influence of glucose and fructose on growing bones. This study compared the effects of dietary glucose and fructose on bone formation, microarchitecture, and strength. Because of the different metabolic effects of glucose and fructose, we hypothesized that their individual effects on bone would be different. Eighteen male Sprague-Dawley rats (age, 60 days) were randomly assigned to high-fructose (n = 9; 40% fructose, 10% glucose) or high-glucose diet (n = 9; 50% glucose) for 12 weeks. Bone measurements included histology and histomorphometry of trabecular bone in the distal femur and a 3-point bending test of the whole tibia. Whole liver mass and postprandial serum glucose, insulin, and triglycerides were used to assess differences in energy metabolism between the diets. There were no differences in food intake, body weight, or visceral adiposity between groups, but fructose consumption led to heavier livers (P = .001) and elevated serum triglycerides (P = .00). The distal femurs of fructose-fed rats had greater bone volume (bone volume/total volume; P = .03), lower bone surface (bone surface/bone volume; P = .02), and thicker trabeculae (trabecular thickness; P = .01). The tibias of the fructose-fed rats also withstood a greater maximum flexure load (P = .032). These results indicate that consumption of the high-fructose diet resulted in stronger bones with enhanced microarchitecture than consumption of the high-glucose diet.

Authors+Show Affiliations

Department of Foods and Nutrition, University of Georgia, Athens, GA, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24267046

Citation

Bass, Erica F., et al. "Bone Quality and Strength Are Greater in Growing Male Rats Fed Fructose Compared With Glucose." Nutrition Research (New York, N.Y.), vol. 33, no. 12, 2013, pp. 1063-71.
Bass EF, Baile CA, Lewis RD, et al. Bone quality and strength are greater in growing male rats fed fructose compared with glucose. Nutr Res. 2013;33(12):1063-71.
Bass, E. F., Baile, C. A., Lewis, R. D., & Giraudo, S. Q. (2013). Bone quality and strength are greater in growing male rats fed fructose compared with glucose. Nutrition Research (New York, N.Y.), 33(12), 1063-71. https://doi.org/10.1016/j.nutres.2013.08.006
Bass EF, et al. Bone Quality and Strength Are Greater in Growing Male Rats Fed Fructose Compared With Glucose. Nutr Res. 2013;33(12):1063-71. PubMed PMID: 24267046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone quality and strength are greater in growing male rats fed fructose compared with glucose. AU - Bass,Erica F, AU - Baile,Clifton A, AU - Lewis,Richard D, AU - Giraudo,Silvia Q, Y1 - 2013/10/09/ PY - 2013/05/17/received PY - 2013/08/10/revised PY - 2013/08/12/accepted PY - 2013/11/26/entrez PY - 2013/11/26/pubmed PY - 2014/7/8/medline KW - Adiposity KW - BFR KW - BMC KW - BMD KW - BS KW - BV KW - Fructose KW - Glucose KW - HFS KW - LFCC KW - MAR KW - MS KW - N.Ob KW - N.Oc KW - Ob.S KW - Osteogenesis KW - Rats KW - TV KW - Tb.N KW - Tb.S KW - Tb.Th KW - bone formation rate KW - bone mineral content KW - bone mineral density KW - bone surface KW - bone volume KW - high-fat sucrose KW - low-fat complex carbohydrate diet KW - mineral acquisition rate KW - mineralizing surface KW - number of osteoblasts KW - number of osteoclasts KW - osteoblast surface KW - total volume KW - trabecular number KW - trabecular surface KW - trabecular thickness SP - 1063 EP - 71 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 33 IS - 12 N2 - Optimization of peak bone mass during adolescence is important for osteoporosis prevention. Studies in rodents and humans have demonstrated the harmful effects of sugar intake on bone health. With the high levels of sucrose in the diets of adolescents, it is necessary to understand the influence of glucose and fructose on growing bones. This study compared the effects of dietary glucose and fructose on bone formation, microarchitecture, and strength. Because of the different metabolic effects of glucose and fructose, we hypothesized that their individual effects on bone would be different. Eighteen male Sprague-Dawley rats (age, 60 days) were randomly assigned to high-fructose (n = 9; 40% fructose, 10% glucose) or high-glucose diet (n = 9; 50% glucose) for 12 weeks. Bone measurements included histology and histomorphometry of trabecular bone in the distal femur and a 3-point bending test of the whole tibia. Whole liver mass and postprandial serum glucose, insulin, and triglycerides were used to assess differences in energy metabolism between the diets. There were no differences in food intake, body weight, or visceral adiposity between groups, but fructose consumption led to heavier livers (P = .001) and elevated serum triglycerides (P = .00). The distal femurs of fructose-fed rats had greater bone volume (bone volume/total volume; P = .03), lower bone surface (bone surface/bone volume; P = .02), and thicker trabeculae (trabecular thickness; P = .01). The tibias of the fructose-fed rats also withstood a greater maximum flexure load (P = .032). These results indicate that consumption of the high-fructose diet resulted in stronger bones with enhanced microarchitecture than consumption of the high-glucose diet. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/24267046/Bone_quality_and_strength_are_greater_in_growing_male_rats_fed_fructose_compared_with_glucose_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(13)00192-9 DB - PRIME DP - Unbound Medicine ER -