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Effect of statin treatment on coronary plaque progression - a serial coronary CT angiography study.
Atherosclerosis. 2013 Dec; 231(2):198-204.A

Abstract

OBJECTIVES

Statins have been shown to reduce plaque progression using data on intravascular ultrasound, carotid intima-media thickness and coronary artery calcium scans. However, there is little data on effects of statins on plaque progression using Coronary CTA. The objective is to evaluate the effect of statin therapy on plaque progression using serial Coronary CTA (CCTA).

METHODS

The study included 100 consecutive patients who underwent serial Coronary CTA (mean follow up: 406 ± 92 days) for evaluation of CAD without known prior heart disease or revascularization. We performed volumetric assessment of low attenuation plaque (LAP < 30 Hounsfield units), non-calcified (NCP) and calcified plaque volumes at baseline and follow up scans for vessels >2 mm in diameter. Patients who received statins were compared to those that did not.

RESULTS

Total plaque progression was significantly reduced among statin user compared to non-statin users (-33.3 mm(3) ± 90.5 vs. 31.0 mm(3) ± 84.5, p = 0.0006). Statin users had significantly reduced progression of NCP volume (-47.7 mm(3) ± 71.9 vs. 13.8 mm(3) ± 76.6, p < 0.001) and significantly reduced progression of LAP volume (-12.2 mm(3) ± 19.2 vs. 5.9 mm(3) ± 23.1, p < 0.0001). When we compared for remodeling index, no statistical difference was found between the two groups (p = 0.25) and a non-significant trend toward calcium progression (29.3 mm(3) ± 67.9 vs. 10.0 mm(3) ± 53.2, p = 0.133). After adjustment for cardiovascular risk factors, mean plaque volume difference between statin and non-statin users was statistically significant for both LAP and NCP volumes (-18.1, 95% CI: -26.4, -9.8 for LAP; -101.7, 95% CI: -162.1, -41.4 for NCP; p < 0.001) respectively.

CONCLUSION

Statin therapy resulted in significantly lower progression of LAP and NCP plaques compared to non-statin users.

Authors+Show Affiliations

Department of Medicine, Bronx-Lebanon Hospital Center, USA. Electronic address: izeb82@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

24267226

Citation

Zeb, Irfan, et al. "Effect of Statin Treatment On Coronary Plaque Progression - a Serial Coronary CT Angiography Study." Atherosclerosis, vol. 231, no. 2, 2013, pp. 198-204.
Zeb I, Li D, Nasir K, et al. Effect of statin treatment on coronary plaque progression - a serial coronary CT angiography study. Atherosclerosis. 2013;231(2):198-204.
Zeb, I., Li, D., Nasir, K., Malpeso, J., Batool, A., Flores, F., Dailing, C., Karlsberg, R. P., & Budoff, M. (2013). Effect of statin treatment on coronary plaque progression - a serial coronary CT angiography study. Atherosclerosis, 231(2), 198-204. https://doi.org/10.1016/j.atherosclerosis.2013.08.019
Zeb I, et al. Effect of Statin Treatment On Coronary Plaque Progression - a Serial Coronary CT Angiography Study. Atherosclerosis. 2013;231(2):198-204. PubMed PMID: 24267226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of statin treatment on coronary plaque progression - a serial coronary CT angiography study. AU - Zeb,Irfan, AU - Li,Dong, AU - Nasir,Khurram, AU - Malpeso,Jennifer, AU - Batool,Aisha, AU - Flores,Ferdinand, AU - Dailing,Christopher, AU - Karlsberg,Ronald P, AU - Budoff,Matthew, Y1 - 2013/08/29/ PY - 2013/05/29/received PY - 2013/07/31/revised PY - 2013/08/19/accepted PY - 2013/11/26/entrez PY - 2013/11/26/pubmed PY - 2014/7/30/medline KW - CAC KW - CAD KW - CP KW - Coronary CTA KW - Coronary plaque KW - LAP KW - MP KW - NCP KW - SCCT KW - Society of Cardiovascular Computed Tomography KW - Statins KW - calcified plaque KW - coronary artery calcium KW - coronary artery disease KW - coronary computed tomography angiography KW - low attenuation plaque KW - mixed plaque KW - non-calcified plaque SP - 198 EP - 204 JF - Atherosclerosis JO - Atherosclerosis VL - 231 IS - 2 N2 - OBJECTIVES: Statins have been shown to reduce plaque progression using data on intravascular ultrasound, carotid intima-media thickness and coronary artery calcium scans. However, there is little data on effects of statins on plaque progression using Coronary CTA. The objective is to evaluate the effect of statin therapy on plaque progression using serial Coronary CTA (CCTA). METHODS: The study included 100 consecutive patients who underwent serial Coronary CTA (mean follow up: 406 ± 92 days) for evaluation of CAD without known prior heart disease or revascularization. We performed volumetric assessment of low attenuation plaque (LAP < 30 Hounsfield units), non-calcified (NCP) and calcified plaque volumes at baseline and follow up scans for vessels >2 mm in diameter. Patients who received statins were compared to those that did not. RESULTS: Total plaque progression was significantly reduced among statin user compared to non-statin users (-33.3 mm(3) ± 90.5 vs. 31.0 mm(3) ± 84.5, p = 0.0006). Statin users had significantly reduced progression of NCP volume (-47.7 mm(3) ± 71.9 vs. 13.8 mm(3) ± 76.6, p < 0.001) and significantly reduced progression of LAP volume (-12.2 mm(3) ± 19.2 vs. 5.9 mm(3) ± 23.1, p < 0.0001). When we compared for remodeling index, no statistical difference was found between the two groups (p = 0.25) and a non-significant trend toward calcium progression (29.3 mm(3) ± 67.9 vs. 10.0 mm(3) ± 53.2, p = 0.133). After adjustment for cardiovascular risk factors, mean plaque volume difference between statin and non-statin users was statistically significant for both LAP and NCP volumes (-18.1, 95% CI: -26.4, -9.8 for LAP; -101.7, 95% CI: -162.1, -41.4 for NCP; p < 0.001) respectively. CONCLUSION: Statin therapy resulted in significantly lower progression of LAP and NCP plaques compared to non-statin users. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/24267226/Effect_of_statin_treatment_on_coronary_plaque_progression___a_serial_coronary_CT_angiography_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(13)00495-4 DB - PRIME DP - Unbound Medicine ER -