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Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study.
Atherosclerosis. 2013 Dec; 231(2):261-7.A

Abstract

OBJECTIVE

We examined the association between the ratio of serum eicosapentaenoic acid to arachidonic acid (EPA/AA) or the docosahexaenoic acid (DHA)/AA and the development of cardiovascular disease in a general Japanese population.

METHODS

A total of 3103 community-dwelling Japanese individuals aged ≥40 years were followed up for an average of 5.1 years. Serum EPA/AA ratios were categorized into quartiles. The risk estimates were computed using a Cox proportional hazards model.

RESULTS

During the follow-up period, 127 subjects experienced cardiovascular events. Age- and sex-adjusted incidence rates of cardiovascular disease increased with lower serum EPA/AA ratios in individuals with high-sensitivity C-reactive protein (HS-CRP) of ≥1.0 mg/L (p for trend = 0.006), whereas no clear association was observed in those with HS-CRP of <1.0 mg/L (p for trend = 0.27). The multivariable-adjusted risk of cardiovascular disease increased significantly, by 1.52 times (95% confidence interval 1.12-2.04) per 0.20 decrement in serum EPA/AA ratio in subjects with HS-CRP of ≥1.0 mg/L. A lower serum EPA/AA ratio was significantly associated with an increased risk of coronary heart disease, but there was no evidence of an association with stroke. The magnitude of the influence of the serum EPA/AA ratio on the cardiovascular risk increased significantly with elevating HS-CRP levels taken as a continuous variable (p for heterogeneity = 0.007). However, no such association was observed for DHA/AA ratio.

CONCLUSION

Our findings suggest that a lower serum EPA/AA ratio is associated with a greater risk of cardiovascular disease, especially coronary heart disease, among subjects with higher HS-CRP levels in the general Japanese population.

Authors+Show Affiliations

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: nino@intmed2.med.kyushu-u.ac.jp.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24267237

Citation

Ninomiya, Toshiharu, et al. "Association Between Ratio of Serum Eicosapentaenoic Acid to Arachidonic Acid and Risk of Cardiovascular Disease: the Hisayama Study." Atherosclerosis, vol. 231, no. 2, 2013, pp. 261-7.
Ninomiya T, Nagata M, Hata J, et al. Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study. Atherosclerosis. 2013;231(2):261-7.
Ninomiya, T., Nagata, M., Hata, J., Hirakawa, Y., Ozawa, M., Yoshida, D., Ohara, T., Kishimoto, H., Mukai, N., Fukuhara, M., Kitazono, T., & Kiyohara, Y. (2013). Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study. Atherosclerosis, 231(2), 261-7. https://doi.org/10.1016/j.atherosclerosis.2013.09.023
Ninomiya T, et al. Association Between Ratio of Serum Eicosapentaenoic Acid to Arachidonic Acid and Risk of Cardiovascular Disease: the Hisayama Study. Atherosclerosis. 2013;231(2):261-7. PubMed PMID: 24267237.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study. AU - Ninomiya,Toshiharu, AU - Nagata,Masaharu, AU - Hata,Jun, AU - Hirakawa,Yoichiro, AU - Ozawa,Mio, AU - Yoshida,Daigo, AU - Ohara,Tomoyuki, AU - Kishimoto,Hiro, AU - Mukai,Naoko, AU - Fukuhara,Masayo, AU - Kitazono,Takanari, AU - Kiyohara,Yutaka, Y1 - 2013/10/05/ PY - 2013/08/19/received PY - 2013/09/24/revised PY - 2013/09/24/accepted PY - 2013/11/26/entrez PY - 2013/11/26/pubmed PY - 2014/7/30/medline KW - AA KW - CI KW - Cardiovascular disease KW - DHA KW - EPA KW - Eicosapentaenoic acid KW - HDL KW - HR KW - HS-CRP KW - High sensitivity C-reactive protein KW - PUFA KW - Prospective cohort study KW - arachidonic acid KW - confidence interval KW - docosahexaenoic acid KW - eicosapentaenoic acid KW - hazard ratio KW - high-density lipoprotein KW - high-sensitivity C-reactive protein KW - polyunsaturated fatty acid SP - 261 EP - 7 JF - Atherosclerosis JO - Atherosclerosis VL - 231 IS - 2 N2 - OBJECTIVE: We examined the association between the ratio of serum eicosapentaenoic acid to arachidonic acid (EPA/AA) or the docosahexaenoic acid (DHA)/AA and the development of cardiovascular disease in a general Japanese population. METHODS: A total of 3103 community-dwelling Japanese individuals aged ≥40 years were followed up for an average of 5.1 years. Serum EPA/AA ratios were categorized into quartiles. The risk estimates were computed using a Cox proportional hazards model. RESULTS: During the follow-up period, 127 subjects experienced cardiovascular events. Age- and sex-adjusted incidence rates of cardiovascular disease increased with lower serum EPA/AA ratios in individuals with high-sensitivity C-reactive protein (HS-CRP) of ≥1.0 mg/L (p for trend = 0.006), whereas no clear association was observed in those with HS-CRP of <1.0 mg/L (p for trend = 0.27). The multivariable-adjusted risk of cardiovascular disease increased significantly, by 1.52 times (95% confidence interval 1.12-2.04) per 0.20 decrement in serum EPA/AA ratio in subjects with HS-CRP of ≥1.0 mg/L. A lower serum EPA/AA ratio was significantly associated with an increased risk of coronary heart disease, but there was no evidence of an association with stroke. The magnitude of the influence of the serum EPA/AA ratio on the cardiovascular risk increased significantly with elevating HS-CRP levels taken as a continuous variable (p for heterogeneity = 0.007). However, no such association was observed for DHA/AA ratio. CONCLUSION: Our findings suggest that a lower serum EPA/AA ratio is associated with a greater risk of cardiovascular disease, especially coronary heart disease, among subjects with higher HS-CRP levels in the general Japanese population. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/24267237/Association_between_ratio_of_serum_eicosapentaenoic_acid_to_arachidonic_acid_and_risk_of_cardiovascular_disease:_the_Hisayama_Study_ DB - PRIME DP - Unbound Medicine ER -