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Gender-specific correlation between plasma myeloperoxidase levels and serum high-density lipoprotein-associated paraoxonase-1 levels in patients with stable and unstable coronary artery disease.

Abstract

OBJECTIVE

Low high-density lipoprotein (HDL) cholesterol is well-established as a negative risk factor for coronary artery disease (CAD) and its anti-oxidant property has been attributed mainly to the HDL-bound enzyme paraoxonase-1 (PON-1). Recently, myeloperoxidase (MPO), a pro-oxidant enzyme released from activated neutrophils, has been shown to alter the atheroprotective function of HDL to a dysfunctional form. This study investigated the relationship between plasma MPO and serum PON-1 levels in patients with stable (SAP) and unstable angina pectoris (UAP).

METHODS

Plasma MPO levels and serum PON-1 concentration/activity were measured in patients with SAP (n = 226), UAP (n = 151) and in control subjects (n = 99).

RESULTS

Plasma MPO levels in UAP patients were significantly higher than those in SAP patients or in control subjects (UAP, 21.6[16.7-44.6]; SAP, 19.3[15.7-29.1]; control, 15.9[14.7-18.7] ng/mL; P < 0.0001). Serum PON-1 concentrations in UAP and SAP patients were significantly lower than those in control subjects (UAP, 55.6[45.9-69.7]; SAP, 55.0[46.9-64.9]; control, 62.5[51.1-78.8] μg/mL; P = 0.0002). Plasma MPO levels showed a weak inverse correlation with serum PON-1 concentrations in all subjects (R = -0.163, P < 0.0005). Moreover, in women, plasma MPO levels showed a significant inverse correlation with serum PON-1 concentrations and PON-arylesterase activity in SAP (concentration: R = -0.537, P < 0.0001; arylesterase-activity: R = -0.469, P < 0.001) and UAP (concentration: R = -0.340, P < 0.05; arylesterase-activity: R = -0.350, P < 0.05) patients, but not in men.

CONCLUSION

This study demonstrates that plasma MPO levels have a significant inverse correlation with PON-1 levels, especially in women, in SAP and UAP patients, and suggests that an imbalance between pro-oxidants and anti-oxidants may contribute to the progression of coronary plaque instability.

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  • Authors+Show Affiliations

    ,

    Department of Cardiology, Osaka City General Hospital, Osaka, Japan.

    , , , , , , , , , , , ,

    Source

    Atherosclerosis 231:2 2013 Dec pg 308-14

    MeSH

    Aged
    Angina, Stable
    Angina, Unstable
    Antioxidants
    Aryldialkylphosphatase
    Biomarkers
    Case-Control Studies
    Coronary Artery Disease
    Diabetes Complications
    Enzyme-Linked Immunosorbent Assay
    Female
    Humans
    Lipoproteins, HDL
    Male
    Middle Aged
    Oxidants
    Oxidative Stress
    Peroxidase
    Polymorphism, Genetic
    Sex Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    24267244

    Citation

    Yunoki, Kei, et al. "Gender-specific Correlation Between Plasma Myeloperoxidase Levels and Serum High-density Lipoprotein-associated Paraoxonase-1 Levels in Patients With Stable and Unstable Coronary Artery Disease." Atherosclerosis, vol. 231, no. 2, 2013, pp. 308-14.
    Yunoki K, Naruko T, Inaba M, et al. Gender-specific correlation between plasma myeloperoxidase levels and serum high-density lipoprotein-associated paraoxonase-1 levels in patients with stable and unstable coronary artery disease. Atherosclerosis. 2013;231(2):308-14.
    Yunoki, K., Naruko, T., Inaba, M., Inoue, T., Nakagawa, M., Sugioka, K., ... Ueda, M. (2013). Gender-specific correlation between plasma myeloperoxidase levels and serum high-density lipoprotein-associated paraoxonase-1 levels in patients with stable and unstable coronary artery disease. Atherosclerosis, 231(2), pp. 308-14. doi:10.1016/j.atherosclerosis.2013.08.037.
    Yunoki K, et al. Gender-specific Correlation Between Plasma Myeloperoxidase Levels and Serum High-density Lipoprotein-associated Paraoxonase-1 Levels in Patients With Stable and Unstable Coronary Artery Disease. Atherosclerosis. 2013;231(2):308-14. PubMed PMID: 24267244.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Gender-specific correlation between plasma myeloperoxidase levels and serum high-density lipoprotein-associated paraoxonase-1 levels in patients with stable and unstable coronary artery disease. AU - Yunoki,Kei, AU - Naruko,Takahiko, AU - Inaba,Mayumi, AU - Inoue,Takeshi, AU - Nakagawa,Masashi, AU - Sugioka,Kenichi, AU - Ohsawa,Masahiko, AU - Iwasa,Yoko, AU - Komatsu,Ryushi, AU - Itoh,Akira, AU - Haze,Kazuo, AU - Yoshiyama,Minoru, AU - Becker,Anton E, AU - Ueda,Makiko, Y1 - 2013/10/08/ PY - 2013/02/20/received PY - 2013/07/03/revised PY - 2013/08/27/accepted PY - 2013/11/26/entrez PY - 2013/11/26/pubmed PY - 2014/7/30/medline KW - Angina KW - Myeloperoxidase KW - Oxidative stress KW - Paraoxonase SP - 308 EP - 14 JF - Atherosclerosis JO - Atherosclerosis VL - 231 IS - 2 N2 - OBJECTIVE: Low high-density lipoprotein (HDL) cholesterol is well-established as a negative risk factor for coronary artery disease (CAD) and its anti-oxidant property has been attributed mainly to the HDL-bound enzyme paraoxonase-1 (PON-1). Recently, myeloperoxidase (MPO), a pro-oxidant enzyme released from activated neutrophils, has been shown to alter the atheroprotective function of HDL to a dysfunctional form. This study investigated the relationship between plasma MPO and serum PON-1 levels in patients with stable (SAP) and unstable angina pectoris (UAP). METHODS: Plasma MPO levels and serum PON-1 concentration/activity were measured in patients with SAP (n = 226), UAP (n = 151) and in control subjects (n = 99). RESULTS: Plasma MPO levels in UAP patients were significantly higher than those in SAP patients or in control subjects (UAP, 21.6[16.7-44.6]; SAP, 19.3[15.7-29.1]; control, 15.9[14.7-18.7] ng/mL; P < 0.0001). Serum PON-1 concentrations in UAP and SAP patients were significantly lower than those in control subjects (UAP, 55.6[45.9-69.7]; SAP, 55.0[46.9-64.9]; control, 62.5[51.1-78.8] μg/mL; P = 0.0002). Plasma MPO levels showed a weak inverse correlation with serum PON-1 concentrations in all subjects (R = -0.163, P < 0.0005). Moreover, in women, plasma MPO levels showed a significant inverse correlation with serum PON-1 concentrations and PON-arylesterase activity in SAP (concentration: R = -0.537, P < 0.0001; arylesterase-activity: R = -0.469, P < 0.001) and UAP (concentration: R = -0.340, P < 0.05; arylesterase-activity: R = -0.350, P < 0.05) patients, but not in men. CONCLUSION: This study demonstrates that plasma MPO levels have a significant inverse correlation with PON-1 levels, especially in women, in SAP and UAP patients, and suggests that an imbalance between pro-oxidants and anti-oxidants may contribute to the progression of coronary plaque instability. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/24267244/Gender_specific_correlation_between_plasma_myeloperoxidase_levels_and_serum_high_density_lipoprotein_associated_paraoxonase_1_levels_in_patients_with_stable_and_unstable_coronary_artery_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(13)00513-3 DB - PRIME DP - Unbound Medicine ER -