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Oxidized low-density lipoprotein, matrix-metalloproteinase-8 and carotid atherosclerosis in spinal cord injured subjects.
Atherosclerosis. 2013 Dec; 231(2):341-5.A

Abstract

OBJECTIVE

Previous reports have indicated that subjects with chronic spinal cord injury (SCI) exhibit increased cardiovascular risk compared to able-bodied individuals. This study investigated the relationship between plasmatic oxidized low-density lipoprotein (OxLDL), matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) levels and vascular remodeling in SCI subjects and the role of physical activity in this regard.

METHODS

We studied 42 men with chronic (≥2 years) SCI [18 sedentary (S-SCI) and 24 physically active (PA-SCI)] and 16 able-bodied men by clinical, anthropometric, laboratory, and carotid intima-media thickness (IMT) analysis. All enrolled subjects were normotensive, non-diabetics, non-smokers and normolipemic. Plasmatic OxLDL, MMP-2, MMP-8, MMP-9, TIMP-1 and TIMP-2 levels were determined by enzyme-linked immunosorbent assay.

RESULTS

Carotid IMT, IMT/diameter ratio and OxLDL levels of PA-SCI and able-bodied subjects were statistically similar. Conversely, S-SCI subjects exhibited higher IMT, IMT/diameter ratio and OxLDL levels compared to PA-SCI (p < 0.01, p < 0.001 and p = 0.01, respectively) and able-bodied (p < 0.001 for all) individuals. Results of bivariate correlation analysis including all injured subjects showed that carotid IMT and IMT/diameter ratio only correlated with OxLDL, MMP-8 and MMP-8/TIMP-1 ratio. Further stepwise regression analysis adjusted for the presence or not of physical activity and age showed that OxLDL was associated with carotid IMT and IMT/diameter ratio, while MMP-8 was associated with IMT/diameter ratio in SCI individuals.

CONCLUSIONS

Plasmatic OxLDL and MMP-8 levels are associated with carotid atherosclerosis and there is an interaction among physical inactivity, atherosclerosis and OxLDL in SCI individuals.

Authors+Show Affiliations

Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24267248

Citation

Paim, Layde R., et al. "Oxidized Low-density Lipoprotein, Matrix-metalloproteinase-8 and Carotid Atherosclerosis in Spinal Cord Injured Subjects." Atherosclerosis, vol. 231, no. 2, 2013, pp. 341-5.
Paim LR, Schreiber R, Matos-Souza JR, et al. Oxidized low-density lipoprotein, matrix-metalloproteinase-8 and carotid atherosclerosis in spinal cord injured subjects. Atherosclerosis. 2013;231(2):341-5.
Paim, L. R., Schreiber, R., Matos-Souza, J. R., Silva, A. A., Campos, L. F., Azevedo, E. R., Alonso, K., de Rossi, G., Etchebehere, M., Gorla, J. I., Cliquet, A., & Nadruz, W. (2013). Oxidized low-density lipoprotein, matrix-metalloproteinase-8 and carotid atherosclerosis in spinal cord injured subjects. Atherosclerosis, 231(2), 341-5. https://doi.org/10.1016/j.atherosclerosis.2013.10.005
Paim LR, et al. Oxidized Low-density Lipoprotein, Matrix-metalloproteinase-8 and Carotid Atherosclerosis in Spinal Cord Injured Subjects. Atherosclerosis. 2013;231(2):341-5. PubMed PMID: 24267248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidized low-density lipoprotein, matrix-metalloproteinase-8 and carotid atherosclerosis in spinal cord injured subjects. AU - Paim,Layde R, AU - Schreiber,Roberto, AU - Matos-Souza,José R, AU - Silva,Anselmo A, AU - Campos,Luis F, AU - Azevedo,Eliza R, AU - Alonso,Karina, AU - de Rossi,Guilherme, AU - Etchebehere,Maurício, AU - Gorla,José I, AU - Cliquet,Alberto,Jr AU - Nadruz,Wilson,Jr Y1 - 2013/10/15/ PY - 2013/07/04/received PY - 2013/09/01/revised PY - 2013/10/02/accepted PY - 2013/11/26/entrez PY - 2013/11/26/pubmed PY - 2014/7/30/medline KW - Intima-media thickness KW - Metalloproteinases KW - Oxidized LDL KW - Paraplegia KW - Tetraplegia SP - 341 EP - 5 JF - Atherosclerosis JO - Atherosclerosis VL - 231 IS - 2 N2 - OBJECTIVE: Previous reports have indicated that subjects with chronic spinal cord injury (SCI) exhibit increased cardiovascular risk compared to able-bodied individuals. This study investigated the relationship between plasmatic oxidized low-density lipoprotein (OxLDL), matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) levels and vascular remodeling in SCI subjects and the role of physical activity in this regard. METHODS: We studied 42 men with chronic (≥2 years) SCI [18 sedentary (S-SCI) and 24 physically active (PA-SCI)] and 16 able-bodied men by clinical, anthropometric, laboratory, and carotid intima-media thickness (IMT) analysis. All enrolled subjects were normotensive, non-diabetics, non-smokers and normolipemic. Plasmatic OxLDL, MMP-2, MMP-8, MMP-9, TIMP-1 and TIMP-2 levels were determined by enzyme-linked immunosorbent assay. RESULTS: Carotid IMT, IMT/diameter ratio and OxLDL levels of PA-SCI and able-bodied subjects were statistically similar. Conversely, S-SCI subjects exhibited higher IMT, IMT/diameter ratio and OxLDL levels compared to PA-SCI (p < 0.01, p < 0.001 and p = 0.01, respectively) and able-bodied (p < 0.001 for all) individuals. Results of bivariate correlation analysis including all injured subjects showed that carotid IMT and IMT/diameter ratio only correlated with OxLDL, MMP-8 and MMP-8/TIMP-1 ratio. Further stepwise regression analysis adjusted for the presence or not of physical activity and age showed that OxLDL was associated with carotid IMT and IMT/diameter ratio, while MMP-8 was associated with IMT/diameter ratio in SCI individuals. CONCLUSIONS: Plasmatic OxLDL and MMP-8 levels are associated with carotid atherosclerosis and there is an interaction among physical inactivity, atherosclerosis and OxLDL in SCI individuals. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/24267248/Oxidized_low_density_lipoprotein_matrix_metalloproteinase_8_and_carotid_atherosclerosis_in_spinal_cord_injured_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(13)00602-3 DB - PRIME DP - Unbound Medicine ER -