Tags

Type your tag names separated by a space and hit enter

Late-onset obsessive-compulsive disorder: risk factors and correlates.
J Psychiatr Res 2014; 49:68-74JP

Abstract

BACKGROUND

While a great amount of attention has been paid to early-onset obsessive-compulsive disorder (OCD), there is a dearth of studies on patients showing OCD for the first time at later stages of life. In this study, we aimed at determining possible risk factors/correlates for OCD onset at or after age 40, here termed late-onset OCD.

METHOD

A series of models including several potential variables associated with late onset OCD were tested using a monolayer neural network. To this regard, data from the Brazilian Research Consortium of Obsessive-Compulsive Spectrum Disorders (CTOC) (n = 1001) was employed. For the purposes of this study, we considered a diagnosis of late onset OCD to be present whenever distress and interference associated with OCD symptoms emerged at or after age 40. Different nested models were compared through the Akaike Criteria keeping the variables with p value ≤0.05.

RESULTS

Late-onset OCD occurred in 8.6% of the sample. A model including female sex, a history of chronic (>10 years) subclinical obsessive-compulsive symptoms, the co-occurrence of posttraumatic stress disorder (PTSD) after age 40, and a history of recent pregnancy in self or significant others was able to explain a sizeable proportion of late-onset OCD. The general performance of this model, represented by the Maximum Likelihood R2, was 29.4%.

CONCLUSION

Our results suggest that late-onset OCD is more likely to occur in females, in individuals with long periods of subclinical obsessive-compulsive symptoms, and in association with a major traumatic event occurring after age 40 and a history of recent pregnancy in self or in significant others.

Authors+Show Affiliations

Anxiety and Depression Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro, Brazil; D'Or Institute for Research and Education, Brazil. Electronic address: ilanafryd@yahoo.com.br.D'Or Institute for Research and Education, Brazil.Department of Neurology, Psychology and Psychiatry, Botucatu Medical School, Universidade Estadual Paulista, Brazil.Department of Psychiatry, University of São Paulo Medical School, Brazil.Department of Psychiatry, Health Sciences Federal University of Porto Alegre, Brazil.Department of Psychiatry, Federal University of São Paulo, Brazil.Department of Psychiatry, University of São Paulo Medical School, Brazil.Anxiety and Depression Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro, Brazil; Department of Psychiatry and Mental Health, Institute of Community Health, Fluminense Federal University, Brazil; D'Or Institute for Research and Education, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24267559

Citation

Frydman, Ilana, et al. "Late-onset Obsessive-compulsive Disorder: Risk Factors and Correlates." Journal of Psychiatric Research, vol. 49, 2014, pp. 68-74.
Frydman I, do Brasil PE, Torres AR, et al. Late-onset obsessive-compulsive disorder: risk factors and correlates. J Psychiatr Res. 2014;49:68-74.
Frydman, I., do Brasil, P. E., Torres, A. R., Shavitt, R. G., Ferrão, Y. A., Rosário, M. C., ... Fontenelle, L. F. (2014). Late-onset obsessive-compulsive disorder: risk factors and correlates. Journal of Psychiatric Research, 49, pp. 68-74. doi:10.1016/j.jpsychires.2013.10.021.
Frydman I, et al. Late-onset Obsessive-compulsive Disorder: Risk Factors and Correlates. J Psychiatr Res. 2014;49:68-74. PubMed PMID: 24267559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Late-onset obsessive-compulsive disorder: risk factors and correlates. AU - Frydman,Ilana, AU - do Brasil,Pedro E, AU - Torres,Albina R, AU - Shavitt,Roseli G, AU - Ferrão,Ygor A, AU - Rosário,Maria C, AU - Miguel,Euripedes C, AU - Fontenelle,Leonardo F, Y1 - 2013/11/09/ PY - 2013/08/25/received PY - 2013/10/03/revised PY - 2013/10/31/accepted PY - 2013/11/26/entrez PY - 2013/11/26/pubmed PY - 2014/8/30/medline KW - Clinical course KW - Late-onset KW - Obsessive-compulsive disorder KW - Onset KW - Phenotype SP - 68 EP - 74 JF - Journal of psychiatric research JO - J Psychiatr Res VL - 49 N2 - BACKGROUND: While a great amount of attention has been paid to early-onset obsessive-compulsive disorder (OCD), there is a dearth of studies on patients showing OCD for the first time at later stages of life. In this study, we aimed at determining possible risk factors/correlates for OCD onset at or after age 40, here termed late-onset OCD. METHOD: A series of models including several potential variables associated with late onset OCD were tested using a monolayer neural network. To this regard, data from the Brazilian Research Consortium of Obsessive-Compulsive Spectrum Disorders (CTOC) (n = 1001) was employed. For the purposes of this study, we considered a diagnosis of late onset OCD to be present whenever distress and interference associated with OCD symptoms emerged at or after age 40. Different nested models were compared through the Akaike Criteria keeping the variables with p value ≤0.05. RESULTS: Late-onset OCD occurred in 8.6% of the sample. A model including female sex, a history of chronic (>10 years) subclinical obsessive-compulsive symptoms, the co-occurrence of posttraumatic stress disorder (PTSD) after age 40, and a history of recent pregnancy in self or significant others was able to explain a sizeable proportion of late-onset OCD. The general performance of this model, represented by the Maximum Likelihood R2, was 29.4%. CONCLUSION: Our results suggest that late-onset OCD is more likely to occur in females, in individuals with long periods of subclinical obsessive-compulsive symptoms, and in association with a major traumatic event occurring after age 40 and a history of recent pregnancy in self or in significant others. SN - 1879-1379 UR - https://www.unboundmedicine.com/medline/citation/24267559/Late_onset_obsessive_compulsive_disorder:_risk_factors_and_correlates_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3956(13)00338-5 DB - PRIME DP - Unbound Medicine ER -