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Pituitary function and DHEA-S in male acne and DHEA-S, prolactin and cortisol before and after oral contraceptive treatment in female acne.
Acta Derm Venereol. 1986; 66(3):225-30.AD

Abstract

Pituitary function (TRH-LHRH stimulation test) was investigated in male acne patients and serum levels of dehydroepiandrosterone sulphate (DHEA-S), sex hormone binding globulin (SHBG) and other biochemical parameters were investigated in male acne patients and in female acne patients before and after treatment with an oral contraceptive. The TRH-LHRH stimulation test was performed with 15 male patients suffering from severe cystic acne and 7 healthy volunteers. Basal and stimulated prolactin, LH and FSH levels were statistically similar in the patients and control groups. However, the stimulated LH levels of the patients were 60% higher than those in controls. SHBG levels were significantly) higher in the patient group compared to those in the control group. Thirty-three female acne patients were randomly divided into two groups and treated for six months with an oral contraceptive containing 0.030 mg ethinylestradiol (EE) plus 0.150 mg levonorgestrel or 0.150 mg levonorgestrel. After six months' treatment a 30% decrease in DHEA-S levels were observed in the desogestrel/EE group and a 15% decrease in the levonorgestrel/EE group; the difference was not statistically significant. At the same time serum total cortisol increased by 75-100% and free testosterone fell by 30-40% in both groups, whereas SHBG elevated 250% in the desogestrel/EE group and 30% in the levonorgestrel/EE group. Acne improved significantly in both groups, desogestrel/EE showing greater improvement. A decrease in SHBG and increase in DHEA-S levels appear to be the most common hormonal changes in acne. Oral contraceptive treatment induces an increase in SHBG and decrease in DHEA-S and also improves acne.

Authors

Palatsi R
No affiliation info available
Reinilä M
No affiliation info available
Kivinén S
No affiliation info available

MeSH

Acne VulgarisAdolescentAdultContraceptives, Oral, CombinedDehydroepiandrosteroneDehydroepiandrosterone SulfateDesogestrelEthinyl EstradiolFemaleFollicle Stimulating HormoneHumansHydrocortisoneLevonorgestrelLuteinizing HormoneMaleNorgestrelNorpregnenesPituitary GlandProlactinSex Hormone-Binding GlobulinTestosterone

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

2426899

Citation

Palatsi, R, et al. "Pituitary Function and DHEA-S in Male Acne and DHEA-S, Prolactin and Cortisol Before and After Oral Contraceptive Treatment in Female Acne." Acta Dermato-venereologica, vol. 66, no. 3, 1986, pp. 225-30.
Palatsi R, Reinilä M, Kivinén S. Pituitary function and DHEA-S in male acne and DHEA-S, prolactin and cortisol before and after oral contraceptive treatment in female acne. Acta Derm Venereol. 1986;66(3):225-30.
Palatsi, R., Reinilä, M., & Kivinén, S. (1986). Pituitary function and DHEA-S in male acne and DHEA-S, prolactin and cortisol before and after oral contraceptive treatment in female acne. Acta Dermato-venereologica, 66(3), 225-30.
Palatsi R, Reinilä M, Kivinén S. Pituitary Function and DHEA-S in Male Acne and DHEA-S, Prolactin and Cortisol Before and After Oral Contraceptive Treatment in Female Acne. Acta Derm Venereol. 1986;66(3):225-30. PubMed PMID: 2426899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pituitary function and DHEA-S in male acne and DHEA-S, prolactin and cortisol before and after oral contraceptive treatment in female acne. AU - Palatsi,R, AU - Reinilä,M, AU - Kivinén,S, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez KW - Acne--prevention and control KW - Androgens KW - Biology KW - Clinical Research KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods--beneficial effects KW - Dermatitis KW - Dermatological Effects KW - Diseases KW - Endocrine System KW - Family Planning KW - Hormones KW - Levonorgestrel KW - Oral Contraceptives--beneficial effects KW - Physiology KW - Pituitary Gland KW - Pituitary Hormone Releasing Hormones KW - Reproductive Control Agents KW - Research Methodology SP - 225 EP - 30 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 66 IS - 3 N2 - Pituitary function (TRH-LHRH stimulation test) was investigated in male acne patients and serum levels of dehydroepiandrosterone sulphate (DHEA-S), sex hormone binding globulin (SHBG) and other biochemical parameters were investigated in male acne patients and in female acne patients before and after treatment with an oral contraceptive. The TRH-LHRH stimulation test was performed with 15 male patients suffering from severe cystic acne and 7 healthy volunteers. Basal and stimulated prolactin, LH and FSH levels were statistically similar in the patients and control groups. However, the stimulated LH levels of the patients were 60% higher than those in controls. SHBG levels were significantly) higher in the patient group compared to those in the control group. Thirty-three female acne patients were randomly divided into two groups and treated for six months with an oral contraceptive containing 0.030 mg ethinylestradiol (EE) plus 0.150 mg levonorgestrel or 0.150 mg levonorgestrel. After six months' treatment a 30% decrease in DHEA-S levels were observed in the desogestrel/EE group and a 15% decrease in the levonorgestrel/EE group; the difference was not statistically significant. At the same time serum total cortisol increased by 75-100% and free testosterone fell by 30-40% in both groups, whereas SHBG elevated 250% in the desogestrel/EE group and 30% in the levonorgestrel/EE group. Acne improved significantly in both groups, desogestrel/EE showing greater improvement. A decrease in SHBG and increase in DHEA-S levels appear to be the most common hormonal changes in acne. Oral contraceptive treatment induces an increase in SHBG and decrease in DHEA-S and also improves acne. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/2426899/Pituitary_function_and_DHEA_S_in_male_acne_and_DHEA_S_prolactin_and_cortisol_before_and_after_oral_contraceptive_treatment_in_female_acne_ DB - PRIME DP - Unbound Medicine ER -