Citation
Pratali, Lorenza, et al. "RV Contractility and Exercise-induced Pulmonary Hypertension in Chronic Mountain Sickness: a Stress Echocardiographic and Tissue Doppler Imaging Study." JACC. Cardiovascular Imaging, vol. 6, no. 12, 2013, pp. 1287-97.
Pratali L, Allemann Y, Rimoldi SF, et al. RV contractility and exercise-induced pulmonary hypertension in chronic mountain sickness: a stress echocardiographic and tissue Doppler imaging study. JACC Cardiovasc Imaging. 2013;6(12):1287-97.
Pratali, L., Allemann, Y., Rimoldi, S. F., Faita, F., Hutter, D., Rexhaj, E., Brenner, R., Bailey, D. M., Sartori, C., Salmon, C. S., Villena, M., Scherrer, U., Picano, E., & Sicari, R. (2013). RV contractility and exercise-induced pulmonary hypertension in chronic mountain sickness: a stress echocardiographic and tissue Doppler imaging study. JACC. Cardiovascular Imaging, 6(12), 1287-97. https://doi.org/10.1016/j.jcmg.2013.08.007
Pratali L, et al. RV Contractility and Exercise-induced Pulmonary Hypertension in Chronic Mountain Sickness: a Stress Echocardiographic and Tissue Doppler Imaging Study. JACC Cardiovasc Imaging. 2013;6(12):1287-97. PubMed PMID: 24269266.
TY - JOUR
T1 - RV contractility and exercise-induced pulmonary hypertension in chronic mountain sickness: a stress echocardiographic and tissue Doppler imaging study.
AU - Pratali,Lorenza,
AU - Allemann,Yves,
AU - Rimoldi,Stefano F,
AU - Faita,Francesco,
AU - Hutter,Damian,
AU - Rexhaj,Emrush,
AU - Brenner,Roman,
AU - Bailey,Damian M,
AU - Sartori,Claudio,
AU - Salmon,Carlos Salinas,
AU - Villena,Mercedes,
AU - Scherrer,Urs,
AU - Picano,Eugenio,
AU - Sicari,Rosa,
Y1 - 2013/10/23/
PY - 2013/05/17/received
PY - 2013/08/02/revised
PY - 2013/08/09/accepted
PY - 2013/11/26/entrez
PY - 2013/11/26/pubmed
PY - 2014/8/12/medline
KW - CMS
KW - E
KW - E/e′
KW - HA
KW - Hb
KW - LV
KW - PAP
KW - RV
KW - RV-ESPAR
KW - RV-S′
KW - TDI
KW - chronic mountain sickness
KW - exercise echocardiography
KW - e′
KW - hemoglobin
KW - high altitude
KW - left ventricular
KW - peak early diastolic tissue Doppler imaging velocity of the mitral annulus
KW - peak velocity of early mitral inflow
KW - pulmonary arterial pressure
KW - ratio of early (e′) and late (a′) diastolic tissue Doppler imaging tricuspid peak annular velocities
KW - ratio of peak velocity of early mitral inflow to mitral annular early diastolic peak velocity
KW - right ventricular
KW - right ventricular end-systolic pressure-area relationship
KW - right ventricular function
KW - systolic pulmonary hypertension
KW - tissue Doppler imaging
KW - tissue Doppler imaging peak systolic velocity of the lateral tricuspid valve annulus
KW - tric e′/a′
SP - 1287
EP - 97
JF - JACC. Cardiovascular imaging
JO - JACC Cardiovasc Imaging
VL - 6
IS - 12
N2 - OBJECTIVES: The aim of this study was to evaluate right ventricular (RV) and left ventricular function and pulmonary circulation in chronic mountain sickness (CMS) patients with rest and stress echocardiography compared with healthy high-altitude (HA) dwellers. BACKGROUND: CMS or Monge's disease is defined by excessive erythrocytosis (hemoglobin >21 g/dl in males, 19 g/dl in females) and severe hypoxemia. In some cases, a moderate or severe increase in pulmonary pressure is present, suggesting a similar pathogenesis of pulmonary hypertension. METHODS: In La Paz (Bolivia, 3,600 m sea level), 46 CMS patients and 40 HA dwellers of similar age were evaluated at rest and during semisupine bicycle exercise. Pulmonary artery pressure (PAP), pulmonary vascular resistance, and cardiac function were estimated by Doppler echocardiography. RESULTS: Compared with HA dwellers, CMS patients showed RV dilation at rest (RV mid diameter: 36 ± 5 mm vs. 32 ± 4 mm, CMS vs. HA, p = 0.001) and reduced RV fractional area change both at rest (35 ± 9% vs. 43 ± 9%, p = 0.002) and during exercise (36 ± 9% vs. 43 ± 8%, CMS vs. HA, p = 0.005). The RV systolic longitudinal function (RV-S') decreased in CMS patients, whereas it increased in the control patients (p < 0.0001) at peak stress. The RV end-systolic pressure-area relationship, a load independent surrogate of RV contractility, was similar in CMS patients and HA dwellers with a significant increase in systolic PAP and pulmonary vascular resistance in CMS patients (systolic PAP: 50 ± 12 mm Hg vs. 38 ± 8 mm Hg, CMS vs. HA, p < 0.0001; pulmonary vascular resistance: 2.9 ± 1 mm Hg/min/l vs. 2.2 ± 1 mm Hg/min/l, p = 0.03). Both groups showed comparable systolic and diastolic left ventricular function both at rest and during stress. CONCLUSIONS: Comparable RV contractile reserve in CMS and HA suggests that the lower resting values of RV function in CMS may represent a physiological adaptation to chronic hypoxic conditions rather than impaired RV function. (Chronic Mountain Sickness, Systemic Vascular Function [CMS]; NCT01182792).
SN - 1876-7591
UR - https://www.unboundmedicine.com/medline/citation/24269266/RV_contractility_and_exercise_induced_pulmonary_hypertension_in_chronic_mountain_sickness:_a_stress_echocardiographic_and_tissue_Doppler_imaging_study_
DB - PRIME
DP - Unbound Medicine
ER -