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[Necrobiotic xanthogranuloma. Differential diagnosis, treatment and systemic involvement. Case report].

Abstract

CASE REPORT

A 48-year-old male was referred to our hospital for further evaluation of eyelid edema with bilateral yellowish ulcerated nodules. Suspecting a xanthogranulomatosis, imaging tests and biopsy were performed with diagnosis of necrobiotic xanthogranuloma. IgG monoclonal gammapathy was diagnosed in a systemic study. Systemic corticosteroids and cyclosporine were initiated unsuccessfully; therefore intra-lesional injections of triamcinolone were started, which controlled the orbital disease.

DISCUSSION

Necrobiotic xanthogranuloma is a rare condition that usually affects the eyelids and anterior orbit. Its diagnosis is important as it is associated with malignant lymphoproliferative processes. Intra-lesional corticosteroids were effective in our patient.

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  • Authors+Show Affiliations

    ,

    Servicio de Oftalmología, Hospital Universitario La Fe, Valencia, España. Electronic address: empar19@hotmail.com.

    ,

    Servicio de Oftalmología, Hospital Universitario La Fe, Valencia, España; Facultad de Óptica, Universidad de Valencia, Valencia, España.

    ,

    Servicio de Oftalmología, Hospital Universitario La Fe, Valencia, España.

    ,

    Servicio de Anatomía Patológica, Hospital Universitario La Fe, Valencia, España.

    ,

    Servicio de Oftalmología, Hospital Universitario La Fe, Valencia, España.

    Servicio de Oftalmología, Hospital Universitario La Fe, Valencia, España; Departamento de Cirugía, Facultad de Medicina, Universidad de Valencia, Valencia, España; Centro de Investigación de Enfermedades Raras (CIBERER), Valencia, España.

    Source

    MeSH

    Diagnosis, Differential
    History, 17th Century
    Humans
    Male
    Necrobiotic Xanthogranuloma

    Pub Type(s)

    Case Reports
    English Abstract
    Historical Article
    Journal Article

    Language

    spa

    PubMed ID

    24269389

    Citation

    Sanz-Marco, E, et al. "[Necrobiotic Xanthogranuloma. Differential Diagnosis, Treatment and Systemic Involvement. Case Report]." Archivos De La Sociedad Espanola De Oftalmologia, vol. 89, no. 5, 2014, pp. 186-9.
    Sanz-Marco E, España E, López-Prats MJ, et al. [Necrobiotic xanthogranuloma. Differential diagnosis, treatment and systemic involvement. Case report]. Arch Soc Esp Oftalmol. 2014;89(5):186-9.
    Sanz-Marco, E., España, E., López-Prats, M. J., Chirivella-Casanova, M., Aviño, J., & Díaz-Llopis, M. (2014). [Necrobiotic xanthogranuloma. Differential diagnosis, treatment and systemic involvement. Case report]. Archivos De La Sociedad Espanola De Oftalmologia, 89(5), pp. 186-9. doi:10.1016/j.oftal.2012.11.007.
    Sanz-Marco E, et al. [Necrobiotic Xanthogranuloma. Differential Diagnosis, Treatment and Systemic Involvement. Case Report]. Arch Soc Esp Oftalmol. 2014;89(5):186-9. PubMed PMID: 24269389.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - [Necrobiotic xanthogranuloma. Differential diagnosis, treatment and systemic involvement. Case report]. AU - Sanz-Marco,E, AU - España,E, AU - López-Prats,M J, AU - Chirivella-Casanova,M, AU - Aviño,J, AU - Díaz-Llopis,M, Y1 - 2012/12/20/ PY - 2011/01/24/received PY - 2012/10/07/revised PY - 2012/11/07/accepted PY - 2013/11/26/entrez PY - 2013/11/26/pubmed PY - 2015/10/30/medline KW - Corticoides KW - Corticosteroids KW - Gammapatía monoclonal KW - Monoclonal gammapathy KW - Necrobiotic xanthogranuloma KW - Xanthogranuloma KW - Xanthogranulomatosis KW - Xantogranuloma KW - Xantogranuloma necrobiótico KW - Xantogranulomatosis SP - 186 EP - 9 JF - Archivos de la Sociedad Espanola de Oftalmologia JO - Arch Soc Esp Oftalmol VL - 89 IS - 5 N2 - CASE REPORT: A 48-year-old male was referred to our hospital for further evaluation of eyelid edema with bilateral yellowish ulcerated nodules. Suspecting a xanthogranulomatosis, imaging tests and biopsy were performed with diagnosis of necrobiotic xanthogranuloma. IgG monoclonal gammapathy was diagnosed in a systemic study. Systemic corticosteroids and cyclosporine were initiated unsuccessfully; therefore intra-lesional injections of triamcinolone were started, which controlled the orbital disease. DISCUSSION: Necrobiotic xanthogranuloma is a rare condition that usually affects the eyelids and anterior orbit. Its diagnosis is important as it is associated with malignant lymphoproliferative processes. Intra-lesional corticosteroids were effective in our patient. SN - 1989-7286 UR - https://www.unboundmedicine.com/medline/citation/24269389/[Necrobiotic_xanthogranuloma__Differential_diagnosis_treatment_and_systemic_involvement__Case_report]_ L2 - http://www.elsevier.es/en/linksolver/ft/pii/S0365-6691(12)00539-4 DB - PRIME DP - Unbound Medicine ER -