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PVA bio-nanocomposites: a new take-off using cellulose nanocrystals and PLGA nanoparticles.
Carbohydr Polym. 2014 Jan; 99:47-58.CP

Abstract

The formation of a new generation of hybrid bio-nanocomposites is reported: these are intended at modulating the mechanical, thermal and biocompatibility properties of the poly(vinyl alcohol) (PVA) by the combination of cellulose nanocrystals (CNC) and poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) loaded with bovine serum albumin fluorescein isothiocynate conjugate (FITC-BSA). CNC were synthesized from microcrystalline cellulose by hydrolysis, while PLGA nanoparticles were produced by a double emulsion with subsequent solvent evaporation. Firstly, binary bio-nanocomposites with different CNC amounts were developed in order to select the right content of CNC. Next, ternary PVA/CNC/NPs bio-nanocomposites were developed. The addition of CNC increased the elongation properties without compromising the other mechanical responses. Thermal analysis underlined the nucleation effect of the synergic presence of cellulose and nanoparticles. Remarkably, bio-nanocomposite films are suitable to vehiculate biopolymeric nanoparticles to adult bone marrow mesenchymal stem cells successfully, thus representing a new tool for drug delivery strategies.

Authors+Show Affiliations

Institute of Polymer Science and Technology, ICTP - CSIC, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24274478

Citation

Rescignano, N, et al. "PVA Bio-nanocomposites: a New Take-off Using Cellulose Nanocrystals and PLGA Nanoparticles." Carbohydrate Polymers, vol. 99, 2014, pp. 47-58.
Rescignano N, Fortunati E, Montesano S, et al. PVA bio-nanocomposites: a new take-off using cellulose nanocrystals and PLGA nanoparticles. Carbohydr Polym. 2014;99:47-58.
Rescignano, N., Fortunati, E., Montesano, S., Emiliani, C., Kenny, J. M., Martino, S., & Armentano, I. (2014). PVA bio-nanocomposites: a new take-off using cellulose nanocrystals and PLGA nanoparticles. Carbohydrate Polymers, 99, 47-58. https://doi.org/10.1016/j.carbpol.2013.08.061
Rescignano N, et al. PVA Bio-nanocomposites: a New Take-off Using Cellulose Nanocrystals and PLGA Nanoparticles. Carbohydr Polym. 2014;99:47-58. PubMed PMID: 24274478.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PVA bio-nanocomposites: a new take-off using cellulose nanocrystals and PLGA nanoparticles. AU - Rescignano,N, AU - Fortunati,E, AU - Montesano,S, AU - Emiliani,C, AU - Kenny,J M, AU - Martino,S, AU - Armentano,I, Y1 - 2013/08/28/ PY - 2013/07/02/received PY - 2013/08/19/revised PY - 2013/08/22/accepted PY - 2013/11/27/entrez PY - 2013/11/28/pubmed PY - 2014/7/16/medline KW - Bio-nanocomposite KW - Cellulose nanocrystals KW - Poly(vinyl alcohol) KW - Stem cells SP - 47 EP - 58 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 99 N2 - The formation of a new generation of hybrid bio-nanocomposites is reported: these are intended at modulating the mechanical, thermal and biocompatibility properties of the poly(vinyl alcohol) (PVA) by the combination of cellulose nanocrystals (CNC) and poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) loaded with bovine serum albumin fluorescein isothiocynate conjugate (FITC-BSA). CNC were synthesized from microcrystalline cellulose by hydrolysis, while PLGA nanoparticles were produced by a double emulsion with subsequent solvent evaporation. Firstly, binary bio-nanocomposites with different CNC amounts were developed in order to select the right content of CNC. Next, ternary PVA/CNC/NPs bio-nanocomposites were developed. The addition of CNC increased the elongation properties without compromising the other mechanical responses. Thermal analysis underlined the nucleation effect of the synergic presence of cellulose and nanoparticles. Remarkably, bio-nanocomposite films are suitable to vehiculate biopolymeric nanoparticles to adult bone marrow mesenchymal stem cells successfully, thus representing a new tool for drug delivery strategies. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/24274478/PVA_bio_nanocomposites:_a_new_take_off_using_cellulose_nanocrystals_and_PLGA_nanoparticles_ DB - PRIME DP - Unbound Medicine ER -