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An introduction to fast dissolving oral thin film drug delivery systems: a review.
Curr Drug Deliv. 2013 Dec; 10(6):667-84.CD

Abstract

Many pharmaceutical companies are switching their products from tablets to fast dissolving oral thin films (OTFs). Films have all the advantages of tablets (precise dosage, easy administration) and those of liquid dosage forms (easy swallowing, rapid bioavailability). Statistics have shown that four out of five patients prefer orally disintegrating dosage forms over conventional solid oral dosages forms. Pediatric, geriatric, bedridden, emetic patients and those with Central Nervous System disorders, have difficulty in swallowing or chewing solid dosage forms. Many of these patients are non-compliant in administering solid dosage forms due to fear of choking. OTFs when placed on the tip or the floor of the tongue are instantly wet by saliva. As a result, OTFs rapidly hydrate and then disintegrate and/or dissolve to release the medication for local and/or systemic absorption. This technology provides a good platform for patent non- infringing product development and for increasing the patent life-cycle of the existing products. The application of fast dissolving oral thin films is not only limited to buccal fast dissolving system, but also expands to other applications like gastroretentive, sublingual delivery systems. This review highlights the composition including the details of various types of polymers both natural and synthetic, the different types of manufacturing techniques, packaging materials and evaluation tests for the OTFs.

Authors+Show Affiliations

Vivekanand Education Society's College of Pharmacy, Hashu Advani Memorial Complex, behind Collector Colony, Chembur (E), Mumbai-400 074, India. hkathpalia2007@rediffmail.com.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24274635

Citation

Kathpalia, Harsha, and Aasavari Gupte. "An Introduction to Fast Dissolving Oral Thin Film Drug Delivery Systems: a Review." Current Drug Delivery, vol. 10, no. 6, 2013, pp. 667-84.
Kathpalia H, Gupte A. An introduction to fast dissolving oral thin film drug delivery systems: a review. Curr Drug Deliv. 2013;10(6):667-84.
Kathpalia, H., & Gupte, A. (2013). An introduction to fast dissolving oral thin film drug delivery systems: a review. Current Drug Delivery, 10(6), 667-84.
Kathpalia H, Gupte A. An Introduction to Fast Dissolving Oral Thin Film Drug Delivery Systems: a Review. Curr Drug Deliv. 2013;10(6):667-84. PubMed PMID: 24274635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An introduction to fast dissolving oral thin film drug delivery systems: a review. AU - Kathpalia,Harsha, AU - Gupte,Aasavari, PY - 2013/04/10/received PY - 2013/05/06/revised PY - 2013/06/06/accepted PY - 2013/11/27/entrez PY - 2013/11/28/pubmed PY - 2014/7/17/medline SP - 667 EP - 84 JF - Current drug delivery JO - Curr Drug Deliv VL - 10 IS - 6 N2 - Many pharmaceutical companies are switching their products from tablets to fast dissolving oral thin films (OTFs). Films have all the advantages of tablets (precise dosage, easy administration) and those of liquid dosage forms (easy swallowing, rapid bioavailability). Statistics have shown that four out of five patients prefer orally disintegrating dosage forms over conventional solid oral dosages forms. Pediatric, geriatric, bedridden, emetic patients and those with Central Nervous System disorders, have difficulty in swallowing or chewing solid dosage forms. Many of these patients are non-compliant in administering solid dosage forms due to fear of choking. OTFs when placed on the tip or the floor of the tongue are instantly wet by saliva. As a result, OTFs rapidly hydrate and then disintegrate and/or dissolve to release the medication for local and/or systemic absorption. This technology provides a good platform for patent non- infringing product development and for increasing the patent life-cycle of the existing products. The application of fast dissolving oral thin films is not only limited to buccal fast dissolving system, but also expands to other applications like gastroretentive, sublingual delivery systems. This review highlights the composition including the details of various types of polymers both natural and synthetic, the different types of manufacturing techniques, packaging materials and evaluation tests for the OTFs. SN - 1875-5704 UR - https://www.unboundmedicine.com/medline/citation/24274635/An_introduction_to_fast_dissolving_oral_thin_film_drug_delivery_systems:_a_review_ L2 - http://www.eurekaselect.com/118300/article DB - PRIME DP - Unbound Medicine ER -