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Clinical and forensic signs related to ethanol abuse: a mechanistic approach.

Abstract

For good performance in clinical and forensic toxicology, it is important to be aware of the signs and symptoms related to xenobiotic exposure since they will assist clinicians to reach a useful and rapid diagnosis. This manuscript highlights and critically analyses clinical and forensic imaging related to ethanol abuse. Here, signs that may lead to suspected ethanol abuse, but that are not necessarily related to liver disease are thoroughly discussed regarding its underlying mechanisms. This includes flushing and disulfiram reactions, urticaria, palmar erythema, spider telangiectasias, porphyria cutanea tarda, "paper money skin", psoriasis, rhinophyma, Dupuytren's contracture, multiple symmetrical lipomatosis (lipomatosis Lanois-Bensaude, Madelung's disease), pancreatitis-related signs, black hairy tongue, gout, nail changes, fetal alcohol syndrome, seborrheic dermatitis, sialosis and cancer.

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  • Authors+Show Affiliations

    ,

    IINFACTS -- Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Sciences, Advanced Institute of Health Sciences - North, CESPU, CRL , Gandra , Portugal .

    , , , , , ,

    Source

    Toxicology mechanisms and methods 24:2 2014 Feb pg 81-110

    MeSH

    Alcoholism
    Female
    Forensic Toxicology
    Humans
    Male

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    24274640

    Citation

    Dinis-Oliveira, Ricardo Jorge, et al. "Clinical and Forensic Signs Related to Ethanol Abuse: a Mechanistic Approach." Toxicology Mechanisms and Methods, vol. 24, no. 2, 2014, pp. 81-110.
    Dinis-Oliveira RJ, Magalhães T, Moreira R, et al. Clinical and forensic signs related to ethanol abuse: a mechanistic approach. Toxicol Mech Methods. 2014;24(2):81-110.
    Dinis-Oliveira, R. J., Magalhães, T., Moreira, R., Proença, J. B., Pontes, H., Santos, A., ... Carvalho, F. (2014). Clinical and forensic signs related to ethanol abuse: a mechanistic approach. Toxicology Mechanisms and Methods, 24(2), pp. 81-110. doi:10.3109/15376516.2013.869782.
    Dinis-Oliveira RJ, et al. Clinical and Forensic Signs Related to Ethanol Abuse: a Mechanistic Approach. Toxicol Mech Methods. 2014;24(2):81-110. PubMed PMID: 24274640.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Clinical and forensic signs related to ethanol abuse: a mechanistic approach. AU - Dinis-Oliveira,Ricardo Jorge, AU - Magalhães,Teresa, AU - Moreira,Roxana, AU - Proença,Jorge Brandão, AU - Pontes,Helena, AU - Santos,Agostinho, AU - Duarte,José Alberto, AU - Carvalho,Félix, PY - 2013/11/27/entrez PY - 2013/11/28/pubmed PY - 2014/9/26/medline SP - 81 EP - 110 JF - Toxicology mechanisms and methods JO - Toxicol. Mech. Methods VL - 24 IS - 2 N2 - For good performance in clinical and forensic toxicology, it is important to be aware of the signs and symptoms related to xenobiotic exposure since they will assist clinicians to reach a useful and rapid diagnosis. This manuscript highlights and critically analyses clinical and forensic imaging related to ethanol abuse. Here, signs that may lead to suspected ethanol abuse, but that are not necessarily related to liver disease are thoroughly discussed regarding its underlying mechanisms. This includes flushing and disulfiram reactions, urticaria, palmar erythema, spider telangiectasias, porphyria cutanea tarda, "paper money skin", psoriasis, rhinophyma, Dupuytren's contracture, multiple symmetrical lipomatosis (lipomatosis Lanois-Bensaude, Madelung's disease), pancreatitis-related signs, black hairy tongue, gout, nail changes, fetal alcohol syndrome, seborrheic dermatitis, sialosis and cancer. SN - 1537-6524 UR - https://www.unboundmedicine.com/medline/citation/24274640/Clinical_and_forensic_signs_related_to_ethanol_abuse:_a_mechanistic_approach_ L2 - http://www.tandfonline.com/doi/full/10.3109/15376516.2013.869782 DB - PRIME DP - Unbound Medicine ER -