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Surgical management of obesity in patients with morbid obesity and nonalcoholic fatty liver disease.
Clin Liver Dis 2014; 18(1):129-46CL

Abstract

Most patients with severe complex obesity presenting for bariatric-metabolic surgery have nonalcoholic fatty liver disease (NAFLD). NAFLD is associated with central obesity, insulin resistance, type 2 diabetes, hypertension, and obesity-related dyslipidemia. Weight loss should be a primary therapy for NAFLD. However, evidence supporting intentional weight loss as a therapy for NAFLD is limited. Bariatric-metabolic surgery provides the most reliable method of achieving substantial sustained weight loss and the most commonly used procedures are associated with reduced steatosis and lobular inflammatory changes, but there are mixed reports regarding fibrosis. Surgery should complement treatment of obesity-related comorbidity, but not replace established therapy.

Authors+Show Affiliations

Clinical Obesity Research, Baker IDI Heart & Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia; Primary Care Research Unit, Monash University, Melbourne, Australia. Electronic address: john.dixon@bakeridi.edu.au.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24274869

Citation

Dixon, John B.. "Surgical Management of Obesity in Patients With Morbid Obesity and Nonalcoholic Fatty Liver Disease." Clinics in Liver Disease, vol. 18, no. 1, 2014, pp. 129-46.
Dixon JB. Surgical management of obesity in patients with morbid obesity and nonalcoholic fatty liver disease. Clin Liver Dis. 2014;18(1):129-46.
Dixon, J. B. (2014). Surgical management of obesity in patients with morbid obesity and nonalcoholic fatty liver disease. Clinics in Liver Disease, 18(1), pp. 129-46. doi:10.1016/j.cld.2013.09.011.
Dixon JB. Surgical Management of Obesity in Patients With Morbid Obesity and Nonalcoholic Fatty Liver Disease. Clin Liver Dis. 2014;18(1):129-46. PubMed PMID: 24274869.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surgical management of obesity in patients with morbid obesity and nonalcoholic fatty liver disease. A1 - Dixon,John B, Y1 - 2013/10/24/ PY - 2013/11/27/entrez PY - 2013/11/28/pubmed PY - 2014/8/15/medline KW - Diabetes KW - Gastric KW - Hypertension KW - Malabsorption KW - Metabolic KW - Mortality KW - Surgery KW - Weight loss SP - 129 EP - 46 JF - Clinics in liver disease JO - Clin Liver Dis VL - 18 IS - 1 N2 - Most patients with severe complex obesity presenting for bariatric-metabolic surgery have nonalcoholic fatty liver disease (NAFLD). NAFLD is associated with central obesity, insulin resistance, type 2 diabetes, hypertension, and obesity-related dyslipidemia. Weight loss should be a primary therapy for NAFLD. However, evidence supporting intentional weight loss as a therapy for NAFLD is limited. Bariatric-metabolic surgery provides the most reliable method of achieving substantial sustained weight loss and the most commonly used procedures are associated with reduced steatosis and lobular inflammatory changes, but there are mixed reports regarding fibrosis. Surgery should complement treatment of obesity-related comorbidity, but not replace established therapy. SN - 1557-8224 UR - https://www.unboundmedicine.com/medline/citation/24274869/Surgical_management_of_obesity_in_patients_with_morbid_obesity_and_nonalcoholic_fatty_liver_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1089-3261(13)00072-X DB - PRIME DP - Unbound Medicine ER -