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Fear acquisition and extinction in offspring of mothers with anxiety and depressive disorders.
Dev Cogn Neurosci. 2014 Jan; 7:30-42.DC

Abstract

Maternal anxiety and depression are significant risk factors for the development of these disorders in offspring. The pathways through which risk is conferred remain unclear. This study examined fear acquisition and extinction in 26 children at high risk for emotional disorders by virtue of maternal psychopathology (n=14 with a mother with a principal anxiety disorder and n=12 with a mother with a principal unipolar depressive disorder) and 31 low risk controls using a discriminative Pavlovian conditioning procedure. Participants, aged between 7 and 14 years, completed 16 trials of discriminative conditioning of two geometric figures, with (CS+) and without (CS-) an aversive tone (US), followed by 8 extinction trials (4×CS+, 4×CS-). In the context of comparable discriminative conditioning, children of anxious mothers showed larger skin conductance responses during extinction to the CS+ compared to the CS-, and to both CSs from the first to the second block of extinction trials, in comparison with low risk controls. Compared to low risk controls, children of depressed mothers showed smaller skin conductance responses to the CS+ than the CS- during acquisition. These findings suggest distinct psychophysiological premorbid risk markers in offspring of anxious and depressed mothers.

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Authors+Show Affiliations

Waters AM
School of Applied Psychology, Griffith University, Australia. Electronic address: a.waters@griffith.edu.au.
Peters RM
School of Applied Psychology, Griffith University, Australia.
Forrest KE
School of Applied Psychology, Griffith University, Australia.
Zimmer-Gembeck M
School of Applied Psychology, Griffith University, Australia.

MeSH

AdolescentAdultAnxietyAnxiety DisordersChildChild of Impaired ParentsConditioning, ClassicalDepressionDepressive DisorderExtinction, PsychologicalFearFemaleGalvanic Skin ResponseHumansMaleMothers

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24275479

Citation

Waters, Allison M., et al. "Fear Acquisition and Extinction in Offspring of Mothers With Anxiety and Depressive Disorders." Developmental Cognitive Neuroscience, vol. 7, 2014, pp. 30-42.
Waters AM, Peters RM, Forrest KE, et al. Fear acquisition and extinction in offspring of mothers with anxiety and depressive disorders. Dev Cogn Neurosci. 2014;7:30-42.
Waters, A. M., Peters, R. M., Forrest, K. E., & Zimmer-Gembeck, M. (2014). Fear acquisition and extinction in offspring of mothers with anxiety and depressive disorders. Developmental Cognitive Neuroscience, 7, 30-42. https://doi.org/10.1016/j.dcn.2013.10.007
Waters AM, et al. Fear Acquisition and Extinction in Offspring of Mothers With Anxiety and Depressive Disorders. Dev Cogn Neurosci. 2014;7:30-42. PubMed PMID: 24275479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fear acquisition and extinction in offspring of mothers with anxiety and depressive disorders. AU - Waters,Allison M, AU - Peters,Rosie-Mae, AU - Forrest,Kylee E, AU - Zimmer-Gembeck,Melanie, Y1 - 2013/11/06/ PY - 2013/08/23/received PY - 2013/10/27/revised PY - 2013/10/29/accepted PY - 2013/11/27/entrez PY - 2013/11/28/pubmed PY - 2014/5/20/medline KW - Anxiety KW - Children KW - Conditioning KW - Depression KW - Extinction KW - High risk KW - Skin conductance SP - 30 EP - 42 JF - Developmental cognitive neuroscience JO - Dev Cogn Neurosci VL - 7 N2 - Maternal anxiety and depression are significant risk factors for the development of these disorders in offspring. The pathways through which risk is conferred remain unclear. This study examined fear acquisition and extinction in 26 children at high risk for emotional disorders by virtue of maternal psychopathology (n=14 with a mother with a principal anxiety disorder and n=12 with a mother with a principal unipolar depressive disorder) and 31 low risk controls using a discriminative Pavlovian conditioning procedure. Participants, aged between 7 and 14 years, completed 16 trials of discriminative conditioning of two geometric figures, with (CS+) and without (CS-) an aversive tone (US), followed by 8 extinction trials (4×CS+, 4×CS-). In the context of comparable discriminative conditioning, children of anxious mothers showed larger skin conductance responses during extinction to the CS+ compared to the CS-, and to both CSs from the first to the second block of extinction trials, in comparison with low risk controls. Compared to low risk controls, children of depressed mothers showed smaller skin conductance responses to the CS+ than the CS- during acquisition. These findings suggest distinct psychophysiological premorbid risk markers in offspring of anxious and depressed mothers. SN - 1878-9307 UR - https://www.unboundmedicine.com/medline/citation/24275479/Fear_acquisition_and_extinction_in_offspring_of_mothers_with_anxiety_and_depressive_disorders_ DB - PRIME DP - Unbound Medicine ER -