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Potentiation of pressor responses to serotonin by ketamine in isolated perfused rat mesentery.
J Cardiovasc Pharmacol. 1986 Jul-Aug; 8(4):765-70.JC

Abstract

The effects of ketamine on vasoconstrictor responses to periarterial sympathetic nerve stimulation (PNS), norepinephrine (NE), and 5-hydroxytryptamine (5-HT) were studied in normotensive Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). The isolated mesenteric arteries were perfused at a constant rate (5 ml/min), and the perfusion pressure was recorded. The pressor responses to PNS (8 Hz, 2 ms, 30 s) were augmented by ketamine (2 X 10(-5) and 10(-4) M) in WKY and SHR. Those to intraarterially infused NE (3 X 10(-10) M) were statistically unaltered. However, in three of seven arterial preparations from WKY and in six of nine preparations from SHR, ketamine (2 X 10(-5) and 10(-4) M) decreased the pressor responses to NE. In contrast, the responses to intraarterial 5-HT (1.3 X 10(-9) mol) were potentiated by ketamine (2 X 10(-5) and 10(-4) M) in SHR and WKY--to a much greater extent in SHR. Fractional release of tritium by PNS from isolated mesenteric arteries previously labeled with 1-[7,8-(3)H]NE (10(-7) M) was unaltered by ketamine (10(-4) M) in SHR and WKY. Cocaine (10(-5) M) prevented the ketamine-induced potentiation of PNS and 5-HT responses. Ketamine as well as cocaine inhibited the accumulations of [3H]5-HT and [3H]NE in intact mesenteric arteries from SHR and WKY to a comparable extent. In tissues denervated by 6-hydroxydopamine, the accumulation of 5-HT was about 70% (WKY) and 60% (SHR) of those in intact tissues, whereas that of NE was about 11% (WKY) and 9% (SHR).(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2427816

Citation

Fukuda, S, et al. "Potentiation of Pressor Responses to Serotonin By Ketamine in Isolated Perfused Rat Mesentery." Journal of Cardiovascular Pharmacology, vol. 8, no. 4, 1986, pp. 765-70.
Fukuda S, Su C, Lee TJ. Potentiation of pressor responses to serotonin by ketamine in isolated perfused rat mesentery. J Cardiovasc Pharmacol. 1986;8(4):765-70.
Fukuda, S., Su, C., & Lee, T. J. (1986). Potentiation of pressor responses to serotonin by ketamine in isolated perfused rat mesentery. Journal of Cardiovascular Pharmacology, 8(4), 765-70.
Fukuda S, Su C, Lee TJ. Potentiation of Pressor Responses to Serotonin By Ketamine in Isolated Perfused Rat Mesentery. J Cardiovasc Pharmacol. 1986 Jul-Aug;8(4):765-70. PubMed PMID: 2427816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potentiation of pressor responses to serotonin by ketamine in isolated perfused rat mesentery. AU - Fukuda,S, AU - Su,C, AU - Lee,T J, PY - 1986/7/1/pubmed PY - 1986/7/1/medline PY - 1986/7/1/entrez SP - 765 EP - 70 JF - Journal of cardiovascular pharmacology JO - J Cardiovasc Pharmacol VL - 8 IS - 4 N2 - The effects of ketamine on vasoconstrictor responses to periarterial sympathetic nerve stimulation (PNS), norepinephrine (NE), and 5-hydroxytryptamine (5-HT) were studied in normotensive Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). The isolated mesenteric arteries were perfused at a constant rate (5 ml/min), and the perfusion pressure was recorded. The pressor responses to PNS (8 Hz, 2 ms, 30 s) were augmented by ketamine (2 X 10(-5) and 10(-4) M) in WKY and SHR. Those to intraarterially infused NE (3 X 10(-10) M) were statistically unaltered. However, in three of seven arterial preparations from WKY and in six of nine preparations from SHR, ketamine (2 X 10(-5) and 10(-4) M) decreased the pressor responses to NE. In contrast, the responses to intraarterial 5-HT (1.3 X 10(-9) mol) were potentiated by ketamine (2 X 10(-5) and 10(-4) M) in SHR and WKY--to a much greater extent in SHR. Fractional release of tritium by PNS from isolated mesenteric arteries previously labeled with 1-[7,8-(3)H]NE (10(-7) M) was unaltered by ketamine (10(-4) M) in SHR and WKY. Cocaine (10(-5) M) prevented the ketamine-induced potentiation of PNS and 5-HT responses. Ketamine as well as cocaine inhibited the accumulations of [3H]5-HT and [3H]NE in intact mesenteric arteries from SHR and WKY to a comparable extent. In tissues denervated by 6-hydroxydopamine, the accumulation of 5-HT was about 70% (WKY) and 60% (SHR) of those in intact tissues, whereas that of NE was about 11% (WKY) and 9% (SHR).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0160-2446 UR - https://www.unboundmedicine.com/medline/citation/2427816/Potentiation_of_pressor_responses_to_serotonin_by_ketamine_in_isolated_perfused_rat_mesentery_ DB - PRIME DP - Unbound Medicine ER -