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Effectiveness of seasonal trivalent influenza vaccine for preventing influenza virus illness among pregnant women: a population-based case-control study during the 2010-2011 and 2011-2012 influenza seasons.

Abstract

BACKGROUND

Although vaccination with trivalent inactivated influenza vaccine (TIV) is recommended for all pregnant women, no vaccine effectiveness (VE) studies of TIV in pregnant women have assessed laboratory-confirmed influenza outcomes.

METHODS

We conducted a case-control study over 2 influenza seasons (2010-2011 and 2011-2012) among Kaiser Permanente health plan members in 2 metropolitan areas in California and Oregon. We compared the proportion vaccinated among 100 influenza cases (confirmed by reverse transcription polymerase chain reaction) with the proportions vaccinated among 192 controls with acute respiratory illness (ARI) who tested negative for influenza and 200 controls without ARI (matched by season, site, and trimester).

RESULTS

Among influenza cases, 42% were vaccinated during the study season compared to 58% and 63% vaccinated among influenza-negative controls and matched ARI-negative controls, respectively. The adjusted VE of the current season vaccine against influenza A and B was 44% (95% confidence interval [CI], 5%-67%) using the influenza-negative controls and 53% (95% CI, 24%-72%) using the ARI-negative controls. Receipt of the prior season's vaccine, however, had an effect similar to receipt of the current season's vaccine. As such, vaccination in either or both seasons had statistically similar adjusted VE using influenza-negative controls (VE point estimates range = 51%-76%) and ARI-negative controls (48%-76%).

CONCLUSIONS

Influenza vaccination reduced the risk of ARI associated with laboratory-confirmed influenza among pregnant women by about one-half, similar to VE observed among all adults during these seasons.

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  • Authors+Show Affiliations

    ,

    Influenza Division, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.

    , , , , , , , , , , , , , , , ,

    Source

    MeSH

    Adult
    California
    Case-Control Studies
    Female
    Humans
    Influenza Vaccines
    Influenza, Human
    Oregon
    Pregnancy
    Pregnancy Complications, Infectious
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    24280090

    Citation

    Thompson, Mark G., et al. "Effectiveness of Seasonal Trivalent Influenza Vaccine for Preventing Influenza Virus Illness Among Pregnant Women: a Population-based Case-control Study During the 2010-2011 and 2011-2012 Influenza Seasons." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 58, no. 4, 2014, pp. 449-57.
    Thompson MG, Li DK, Shifflett P, et al. Effectiveness of seasonal trivalent influenza vaccine for preventing influenza virus illness among pregnant women: a population-based case-control study during the 2010-2011 and 2011-2012 influenza seasons. Clin Infect Dis. 2014;58(4):449-57.
    Thompson, M. G., Li, D. K., Shifflett, P., Sokolow, L. Z., Ferber, J. R., Kurosky, S., ... Naleway, A. L. (2014). Effectiveness of seasonal trivalent influenza vaccine for preventing influenza virus illness among pregnant women: a population-based case-control study during the 2010-2011 and 2011-2012 influenza seasons. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 58(4), pp. 449-57. doi:10.1093/cid/cit750.
    Thompson MG, et al. Effectiveness of Seasonal Trivalent Influenza Vaccine for Preventing Influenza Virus Illness Among Pregnant Women: a Population-based Case-control Study During the 2010-2011 and 2011-2012 Influenza Seasons. Clin Infect Dis. 2014;58(4):449-57. PubMed PMID: 24280090.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effectiveness of seasonal trivalent influenza vaccine for preventing influenza virus illness among pregnant women: a population-based case-control study during the 2010-2011 and 2011-2012 influenza seasons. AU - Thompson,Mark G, AU - Li,De-Kun, AU - Shifflett,Pat, AU - Sokolow,Leslie Z, AU - Ferber,Jeannette R, AU - Kurosky,Samantha, AU - Bozeman,Sam, AU - Reynolds,Sue B, AU - Odouli,Roxana, AU - Henninger,Michelle L, AU - Kauffman,Tia L, AU - Avalos,Lyndsay A, AU - Ball,Sarah, AU - Williams,Jennifer L, AU - Irving,Stephanie A, AU - Shay,David K, AU - Naleway,Allison L, AU - ,, Y1 - 2013/11/26/ PY - 2013/11/28/entrez PY - 2013/11/28/pubmed PY - 2015/4/23/medline KW - acute respiratory illness KW - influenza KW - influenza vaccines KW - pregnancy KW - vaccine effectiveness SP - 449 EP - 57 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 58 IS - 4 N2 - BACKGROUND: Although vaccination with trivalent inactivated influenza vaccine (TIV) is recommended for all pregnant women, no vaccine effectiveness (VE) studies of TIV in pregnant women have assessed laboratory-confirmed influenza outcomes. METHODS: We conducted a case-control study over 2 influenza seasons (2010-2011 and 2011-2012) among Kaiser Permanente health plan members in 2 metropolitan areas in California and Oregon. We compared the proportion vaccinated among 100 influenza cases (confirmed by reverse transcription polymerase chain reaction) with the proportions vaccinated among 192 controls with acute respiratory illness (ARI) who tested negative for influenza and 200 controls without ARI (matched by season, site, and trimester). RESULTS: Among influenza cases, 42% were vaccinated during the study season compared to 58% and 63% vaccinated among influenza-negative controls and matched ARI-negative controls, respectively. The adjusted VE of the current season vaccine against influenza A and B was 44% (95% confidence interval [CI], 5%-67%) using the influenza-negative controls and 53% (95% CI, 24%-72%) using the ARI-negative controls. Receipt of the prior season's vaccine, however, had an effect similar to receipt of the current season's vaccine. As such, vaccination in either or both seasons had statistically similar adjusted VE using influenza-negative controls (VE point estimates range = 51%-76%) and ARI-negative controls (48%-76%). CONCLUSIONS: Influenza vaccination reduced the risk of ARI associated with laboratory-confirmed influenza among pregnant women by about one-half, similar to VE observed among all adults during these seasons. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/24280090/Effectiveness_of_seasonal_trivalent_influenza_vaccine_for_preventing_influenza_virus_illness_among_pregnant_women:_a_population_based_case_control_study_during_the_2010_2011_and_2011_2012_influenza_seasons_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/cit750 DB - PRIME DP - Unbound Medicine ER -