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Higher optic nerve sheath diameters are associated with lower ocular blood flow velocities in glaucoma patients.
Graefes Arch Clin Exp Ophthalmol. 2014 Mar; 252(3):477-83.GA

Abstract

PURPOSE

To investigate the relationship between optic nerve sheath diameter (ONSD) and retrobulbar blood flow velocities, as measured by color Doppler imaging (CDI) in glaucoma patients.

METHODS

We performed a prospective, randomized, observer-masked study involving a total of 197 subjects. Once enrolled, they were divided by three groups: healthy controls (n = 51), normal-tension glaucoma patients (NTG, n = 58), and primary, open-angle glaucoma patients (POAG, n = 88). All subjects underwent a general ophthalmological examination, an ultrasound-based assessment of the ONSD, and a hemodynamic study of the retrobulbar vascularization using CDI. Non-parametric tests, chi-square contingency tables, and the Deming correlations were used to explore differences and correlations between variables in the diagnostic groups.

RESULTS

ONSD was not different between experimental groups (p = 0.28). ONSD correlated positively with the pulsatility index of the ophthalmic artery in healthy individuals (p = 0.007), but not in glaucoma patients (NTG: p = 0.41; POAG: p = 0.22). In NTG patients, higher ONSD values were associated with lower end-diastolic and mean flow velocities in the short ciliary arteries (p = 0.005 in both correlations). No such correlation was found in healthy nor POAG groups (p range between 0.15 to 0.96). ONSD was not associated with any CDI-related variable of the central retinal artery in any cohort. Venous outflow velocities were not associated with ONSD in any of the three groups.

CONCLUSIONS

ONSD is negatively correlated with retrobulbar blood flow velocities in glaucoma patients, but not in healthy controls.

Authors+Show Affiliations

Department of Ophthalmology, University Hospitals Leuven, Campus St. Raphaël, Kapucijnenvoer 33, 3000, Leuven, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

24281785

Citation

Willekens, Koen, et al. "Higher Optic Nerve Sheath Diameters Are Associated With Lower Ocular Blood Flow Velocities in Glaucoma Patients." Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, vol. 252, no. 3, 2014, pp. 477-83.
Willekens K, Abegão Pinto L, Vandewalle E, et al. Higher optic nerve sheath diameters are associated with lower ocular blood flow velocities in glaucoma patients. Graefes Arch Clin Exp Ophthalmol. 2014;252(3):477-83.
Willekens, K., Abegão Pinto, L., Vandewalle, E., Marques-Neves, C., & Stalmans, I. (2014). Higher optic nerve sheath diameters are associated with lower ocular blood flow velocities in glaucoma patients. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 252(3), 477-83. https://doi.org/10.1007/s00417-013-2533-y
Willekens K, et al. Higher Optic Nerve Sheath Diameters Are Associated With Lower Ocular Blood Flow Velocities in Glaucoma Patients. Graefes Arch Clin Exp Ophthalmol. 2014;252(3):477-83. PubMed PMID: 24281785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher optic nerve sheath diameters are associated with lower ocular blood flow velocities in glaucoma patients. AU - Willekens,Koen, AU - Abegão Pinto,Luís, AU - Vandewalle,Evelien, AU - Marques-Neves,Carlos, AU - Stalmans,Ingeborg, Y1 - 2013/11/27/ PY - 2013/07/23/received PY - 2013/11/13/accepted PY - 2013/11/03/revised PY - 2013/11/28/entrez PY - 2013/11/28/pubmed PY - 2014/8/26/medline SP - 477 EP - 83 JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JO - Graefes Arch Clin Exp Ophthalmol VL - 252 IS - 3 N2 - PURPOSE: To investigate the relationship between optic nerve sheath diameter (ONSD) and retrobulbar blood flow velocities, as measured by color Doppler imaging (CDI) in glaucoma patients. METHODS: We performed a prospective, randomized, observer-masked study involving a total of 197 subjects. Once enrolled, they were divided by three groups: healthy controls (n = 51), normal-tension glaucoma patients (NTG, n = 58), and primary, open-angle glaucoma patients (POAG, n = 88). All subjects underwent a general ophthalmological examination, an ultrasound-based assessment of the ONSD, and a hemodynamic study of the retrobulbar vascularization using CDI. Non-parametric tests, chi-square contingency tables, and the Deming correlations were used to explore differences and correlations between variables in the diagnostic groups. RESULTS: ONSD was not different between experimental groups (p = 0.28). ONSD correlated positively with the pulsatility index of the ophthalmic artery in healthy individuals (p = 0.007), but not in glaucoma patients (NTG: p = 0.41; POAG: p = 0.22). In NTG patients, higher ONSD values were associated with lower end-diastolic and mean flow velocities in the short ciliary arteries (p = 0.005 in both correlations). No such correlation was found in healthy nor POAG groups (p range between 0.15 to 0.96). ONSD was not associated with any CDI-related variable of the central retinal artery in any cohort. Venous outflow velocities were not associated with ONSD in any of the three groups. CONCLUSIONS: ONSD is negatively correlated with retrobulbar blood flow velocities in glaucoma patients, but not in healthy controls. SN - 1435-702X UR - https://www.unboundmedicine.com/medline/citation/24281785/Higher_optic_nerve_sheath_diameters_are_associated_with_lower_ocular_blood_flow_velocities_in_glaucoma_patients_ L2 - https://dx.doi.org/10.1007/s00417-013-2533-y DB - PRIME DP - Unbound Medicine ER -