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Effect of Ginkgo biloba on visual field and contrast sensitivity in Chinese patients with normal tension glaucoma: a randomized, crossover clinical trial.
Invest Ophthalmol Vis Sci 2014; 55(1):110-6IO

Abstract

PURPOSE

We evaluated the effect of ginkgo biloba extract on visual field defect and contrast sensitivity in a Chinese cohort with normal tension glaucoma.

METHODS

In this prospective, randomized, placebo-controlled crossover study, patients newly diagnosed with normal tension glaucoma, either in a tertiary glaucoma clinic (n = 5) or in a cohort undergoing routine general physical examinations in a primary care clinic (n = 30), underwent two 4-week phases of treatment, separated by a washout period of 8 weeks. Randomization determined whether ginkgo biloba extract (40 mg, 3 times per day) or placebo (identical-appearing tablets) was received first. Primary outcomes were change in contrast sensitivity and mean deviation on 24-2 SITA standard visual field testing, while secondary outcomes included IOP and self-reported adverse events.

RESULTS

A total of 35 patients with mean age 63.7 (6.5) years were randomized to the ginkgo biloba extract-placebo (n = 18) or the placebo-ginkgo biloba extract (n = 17) sequence. A total of 28 patients (80.0%, 14 in each group) who completed testing did not differ at baseline in age, sex, visual field mean deviation, contrast sensitivity, IOP, or blood pressure. Changes in visual field and contrast sensitivity did not differ by treatment received or sequence (P > 0.2 for all). Power to have detected a difference in mean defect as large as previously reported was 80%.

CONCLUSIONS

In contrast to some previous reports, ginkgo biloba extract treatment had no effect on mean defect or contrast sensitivity in this group of normal tension glaucoma patients. (http://www.chictr.org number, ChiCTR-TRC-08000724).

Authors+Show Affiliations

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24282229

Citation

Guo, Xinxing, et al. "Effect of Ginkgo Biloba On Visual Field and Contrast Sensitivity in Chinese Patients With Normal Tension Glaucoma: a Randomized, Crossover Clinical Trial." Investigative Ophthalmology & Visual Science, vol. 55, no. 1, 2014, pp. 110-6.
Guo X, Kong X, Huang R, et al. Effect of Ginkgo biloba on visual field and contrast sensitivity in Chinese patients with normal tension glaucoma: a randomized, crossover clinical trial. Invest Ophthalmol Vis Sci. 2014;55(1):110-6.
Guo, X., Kong, X., Huang, R., Jin, L., Ding, X., He, M., ... Congdon, N. G. (2014). Effect of Ginkgo biloba on visual field and contrast sensitivity in Chinese patients with normal tension glaucoma: a randomized, crossover clinical trial. Investigative Ophthalmology & Visual Science, 55(1), pp. 110-6. doi:10.1167/iovs.13-13168.
Guo X, et al. Effect of Ginkgo Biloba On Visual Field and Contrast Sensitivity in Chinese Patients With Normal Tension Glaucoma: a Randomized, Crossover Clinical Trial. Invest Ophthalmol Vis Sci. 2014 Jan 7;55(1):110-6. PubMed PMID: 24282229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Ginkgo biloba on visual field and contrast sensitivity in Chinese patients with normal tension glaucoma: a randomized, crossover clinical trial. AU - Guo,Xinxing, AU - Kong,Xiangbin, AU - Huang,Rui, AU - Jin,Ling, AU - Ding,Xiaohu, AU - He,Mingguang, AU - Liu,Xing, AU - Patel,Mehul Chimanlal, AU - Congdon,Nathan G, Y1 - 2014/01/07/ PY - 2013/11/28/entrez PY - 2013/11/28/pubmed PY - 2014/2/26/medline KW - Ginkgo biloba KW - contrast sensitivity KW - normal tension glaucoma KW - visual field SP - 110 EP - 6 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 55 IS - 1 N2 - PURPOSE: We evaluated the effect of ginkgo biloba extract on visual field defect and contrast sensitivity in a Chinese cohort with normal tension glaucoma. METHODS: In this prospective, randomized, placebo-controlled crossover study, patients newly diagnosed with normal tension glaucoma, either in a tertiary glaucoma clinic (n = 5) or in a cohort undergoing routine general physical examinations in a primary care clinic (n = 30), underwent two 4-week phases of treatment, separated by a washout period of 8 weeks. Randomization determined whether ginkgo biloba extract (40 mg, 3 times per day) or placebo (identical-appearing tablets) was received first. Primary outcomes were change in contrast sensitivity and mean deviation on 24-2 SITA standard visual field testing, while secondary outcomes included IOP and self-reported adverse events. RESULTS: A total of 35 patients with mean age 63.7 (6.5) years were randomized to the ginkgo biloba extract-placebo (n = 18) or the placebo-ginkgo biloba extract (n = 17) sequence. A total of 28 patients (80.0%, 14 in each group) who completed testing did not differ at baseline in age, sex, visual field mean deviation, contrast sensitivity, IOP, or blood pressure. Changes in visual field and contrast sensitivity did not differ by treatment received or sequence (P > 0.2 for all). Power to have detected a difference in mean defect as large as previously reported was 80%. CONCLUSIONS: In contrast to some previous reports, ginkgo biloba extract treatment had no effect on mean defect or contrast sensitivity in this group of normal tension glaucoma patients. (http://www.chictr.org number, ChiCTR-TRC-08000724). SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/24282229/Effect_of_Ginkgo_biloba_on_visual_field_and_contrast_sensitivity_in_Chinese_patients_with_normal_tension_glaucoma:_a_randomized_crossover_clinical_trial_ L2 - http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.13-13168 DB - PRIME DP - Unbound Medicine ER -