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Nonhormonal management of postmenopausal women: effects of a red clover based isoflavones supplementation on climacteric syndrome and cardiovascular risk serum profile.
Clin Exp Obstet Gynecol. 2013; 40(3):337-41.CE

Abstract

PURPOSE OF INVESTIGATION

The aim of this prospective randomized study was to evaluate a red clover based isoflavones supplementation in the treatment of climacteric syndrome and its effects on cardiovascular risk serum profile.

MATERIALS AND METHODS

The study included 150 healthy postmenopausal women that were randomly assigned to receive phytoestrogens tablets, amounting in a total daily intake of 60.8 mg red clover isoflavones plus 19.2 mg soy isoflavones (n = 75), or placebo (n = 75). The authors evaluated teh following: daily number of hot flushes and Kupperman Index at baseline and after one and three months; serum total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, triglycerides, prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen, and antithrombin III (ATIII) at baseline and after three and six months.

RESULTS

One hundred twenty-eight patients completed the study: 67 in the active group and 61 in the placebo group. The treatment led to a progressive significant reduction (p < 0.05) of the number of hot flushes in the active group compared to placebo already after one month, while Kupperman Index was statistically reduced after three months. No significant variation in total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, PT, PTT, fibrinogen, and ATIII were found.

CONCLUSION

The present findings suggest that a red clover based isoflavones supplementation in healthy postmenopausal women is promptly effective on climacteric syndrome, improves neurovegetative symptoms, safe on cardiovascular risk serum profile, and does not modify lipids and coagulation.

Authors+Show Affiliations

"San Leonardo" Hospital, Castellammare di Stabia, Naples, Italy. giampaolomainini@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

24283160

Citation

Mainini, G, et al. "Nonhormonal Management of Postmenopausal Women: Effects of a Red Clover Based Isoflavones Supplementation On Climacteric Syndrome and Cardiovascular Risk Serum Profile." Clinical and Experimental Obstetrics & Gynecology, vol. 40, no. 3, 2013, pp. 337-41.
Mainini G, Torella M, Di Donna MC, et al. Nonhormonal management of postmenopausal women: effects of a red clover based isoflavones supplementation on climacteric syndrome and cardiovascular risk serum profile. Clin Exp Obstet Gynecol. 2013;40(3):337-41.
Mainini, G., Torella, M., Di Donna, M. C., Esposito, E., Ercolano, S., Correa, R., Cucinella, G., Stradella, L., Luisi, A., Basso, A., Cerreto, F. V., Cicatiello, R., Matteo, M., & De Franciscis, P. (2013). Nonhormonal management of postmenopausal women: effects of a red clover based isoflavones supplementation on climacteric syndrome and cardiovascular risk serum profile. Clinical and Experimental Obstetrics & Gynecology, 40(3), 337-41.
Mainini G, et al. Nonhormonal Management of Postmenopausal Women: Effects of a Red Clover Based Isoflavones Supplementation On Climacteric Syndrome and Cardiovascular Risk Serum Profile. Clin Exp Obstet Gynecol. 2013;40(3):337-41. PubMed PMID: 24283160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonhormonal management of postmenopausal women: effects of a red clover based isoflavones supplementation on climacteric syndrome and cardiovascular risk serum profile. AU - Mainini,G, AU - Torella,M, AU - Di Donna,M C, AU - Esposito,E, AU - Ercolano,S, AU - Correa,R, AU - Cucinella,G, AU - Stradella,L, AU - Luisi,A, AU - Basso,A, AU - Cerreto,F V, AU - Cicatiello,R, AU - Matteo,M, AU - De Franciscis,P, PY - 2013/11/29/entrez PY - 2013/11/29/pubmed PY - 2014/1/8/medline SP - 337 EP - 41 JF - Clinical and experimental obstetrics & gynecology JO - Clin Exp Obstet Gynecol VL - 40 IS - 3 N2 - PURPOSE OF INVESTIGATION: The aim of this prospective randomized study was to evaluate a red clover based isoflavones supplementation in the treatment of climacteric syndrome and its effects on cardiovascular risk serum profile. MATERIALS AND METHODS: The study included 150 healthy postmenopausal women that were randomly assigned to receive phytoestrogens tablets, amounting in a total daily intake of 60.8 mg red clover isoflavones plus 19.2 mg soy isoflavones (n = 75), or placebo (n = 75). The authors evaluated teh following: daily number of hot flushes and Kupperman Index at baseline and after one and three months; serum total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, triglycerides, prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen, and antithrombin III (ATIII) at baseline and after three and six months. RESULTS: One hundred twenty-eight patients completed the study: 67 in the active group and 61 in the placebo group. The treatment led to a progressive significant reduction (p < 0.05) of the number of hot flushes in the active group compared to placebo already after one month, while Kupperman Index was statistically reduced after three months. No significant variation in total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, PT, PTT, fibrinogen, and ATIII were found. CONCLUSION: The present findings suggest that a red clover based isoflavones supplementation in healthy postmenopausal women is promptly effective on climacteric syndrome, improves neurovegetative symptoms, safe on cardiovascular risk serum profile, and does not modify lipids and coagulation. SN - 0390-6663 UR - https://www.unboundmedicine.com/medline/citation/24283160/Nonhormonal_management_of_postmenopausal_women:_effects_of_a_red_clover_based_isoflavones_supplementation_on_climacteric_syndrome_and_cardiovascular_risk_serum_profile_ DB - PRIME DP - Unbound Medicine ER -