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Associations between red meat intake and biomarkers of inflammation and glucose metabolism in women.
Am J Clin Nutr 2014; 99(2):352-60AJ

Abstract

BACKGROUND

Greater red meat intake is associated with an increased type 2 diabetes and cardiovascular disease risk. However, the relation of red meat intake to biomarkers of inflammation and glucose metabolism has not been investigated thoroughly.

OBJECTIVE

We hypothesized that greater red meat intake would be associated with biomarkers of inflammation and glucose metabolism, which would be partly explained by body mass index (BMI).

DESIGN

We analyzed cross-sectional data from diabetes-free female participants in the Nurses' Health Study (n = 3690). Multiple linear regression was conducted to assess the associations of total, unprocessed, and processed red meat intakes (quartile categories) with plasma C-reactive protein (CRP), ferritin, adiponectin, fasting insulin, and hemoglobin A1c (Hb A1c).

RESULTS

Greater total, unprocessed, and processed red meat intakes were associated with higher plasma CRP, ferritin, fasting insulin, and Hb A1c and lower adiponectin after adjustment for demographic information (P-trend ≤ 0.03 for all). Adiponectin was not associated with any type of red meat intake when further adjusted for medical and lifestyle factors. After adjustment for BMI, most of these associations with inflammatory and glucose metabolic biomarkers were substantially attenuated and no longer significant. BMI accounted for a statistically significant proportion of associations with CRP, Hb A1c, and fasting insulin (P-contribution ≤ 0.02 for all) but not with ferritin. Substituting a serving of total red meat intake with alternative protein food in a combination of poultry, fish, legumes, and nuts was associated with significantly lower CRP (β ± SE: -0.106 ± 0.043), ferritin (-0.212 ± 0.075), Hb A1c (-0.052 ± 0.015), and fasting insulin (-0.119 ± 0.036) (all P ≤ 0.02 for comparison of extreme quartiles for all).

CONCLUSIONS

Greater red meat intake is associated with unfavorable plasma concentrations of inflammatory and glucose metabolic biomarkers in diabetes-free women. BMI accounts for a significant proportion of the associations with these biomarkers, except for ferritin. Substituting red meat with another protein food is associated with a healthier biomarker profile of inflammatory and glucose metabolism.

Authors+Show Affiliations

Departments of Nutrition (SHL, QS, WCW, KW, AP, and FBH) and Epidemiology (WCW, FG, and FBH), Harvard School of Public Health, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School (QS, WCW, AHE, FG, and FBH), Boston, MA; and the Saw Swee Hock School of Public Health and Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore (AP).No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24284436

Citation

Ley, Sylvia H., et al. "Associations Between Red Meat Intake and Biomarkers of Inflammation and Glucose Metabolism in Women." The American Journal of Clinical Nutrition, vol. 99, no. 2, 2014, pp. 352-60.
Ley SH, Sun Q, Willett WC, et al. Associations between red meat intake and biomarkers of inflammation and glucose metabolism in women. Am J Clin Nutr. 2014;99(2):352-60.
Ley, S. H., Sun, Q., Willett, W. C., Eliassen, A. H., Wu, K., Pan, A., ... Hu, F. B. (2014). Associations between red meat intake and biomarkers of inflammation and glucose metabolism in women. The American Journal of Clinical Nutrition, 99(2), pp. 352-60. doi:10.3945/ajcn.113.075663.
Ley SH, et al. Associations Between Red Meat Intake and Biomarkers of Inflammation and Glucose Metabolism in Women. Am J Clin Nutr. 2014;99(2):352-60. PubMed PMID: 24284436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between red meat intake and biomarkers of inflammation and glucose metabolism in women. AU - Ley,Sylvia H, AU - Sun,Qi, AU - Willett,Walter C, AU - Eliassen,A Heather, AU - Wu,Kana, AU - Pan,An, AU - Grodstein,Fran, AU - Hu,Frank B, Y1 - 2013/11/27/ PY - 2013/11/29/entrez PY - 2013/11/29/pubmed PY - 2014/4/15/medline SP - 352 EP - 60 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 99 IS - 2 N2 - BACKGROUND: Greater red meat intake is associated with an increased type 2 diabetes and cardiovascular disease risk. However, the relation of red meat intake to biomarkers of inflammation and glucose metabolism has not been investigated thoroughly. OBJECTIVE: We hypothesized that greater red meat intake would be associated with biomarkers of inflammation and glucose metabolism, which would be partly explained by body mass index (BMI). DESIGN: We analyzed cross-sectional data from diabetes-free female participants in the Nurses' Health Study (n = 3690). Multiple linear regression was conducted to assess the associations of total, unprocessed, and processed red meat intakes (quartile categories) with plasma C-reactive protein (CRP), ferritin, adiponectin, fasting insulin, and hemoglobin A1c (Hb A1c). RESULTS: Greater total, unprocessed, and processed red meat intakes were associated with higher plasma CRP, ferritin, fasting insulin, and Hb A1c and lower adiponectin after adjustment for demographic information (P-trend ≤ 0.03 for all). Adiponectin was not associated with any type of red meat intake when further adjusted for medical and lifestyle factors. After adjustment for BMI, most of these associations with inflammatory and glucose metabolic biomarkers were substantially attenuated and no longer significant. BMI accounted for a statistically significant proportion of associations with CRP, Hb A1c, and fasting insulin (P-contribution ≤ 0.02 for all) but not with ferritin. Substituting a serving of total red meat intake with alternative protein food in a combination of poultry, fish, legumes, and nuts was associated with significantly lower CRP (β ± SE: -0.106 ± 0.043), ferritin (-0.212 ± 0.075), Hb A1c (-0.052 ± 0.015), and fasting insulin (-0.119 ± 0.036) (all P ≤ 0.02 for comparison of extreme quartiles for all). CONCLUSIONS: Greater red meat intake is associated with unfavorable plasma concentrations of inflammatory and glucose metabolic biomarkers in diabetes-free women. BMI accounts for a significant proportion of the associations with these biomarkers, except for ferritin. Substituting red meat with another protein food is associated with a healthier biomarker profile of inflammatory and glucose metabolism. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/24284436/Associations_between_red_meat_intake_and_biomarkers_of_inflammation_and_glucose_metabolism_in_women_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.113.075663 DB - PRIME DP - Unbound Medicine ER -