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Cysteine and cysteine-related signaling pathways in Arabidopsis thaliana.
Mol Plant 2014; 7(2):264-76MP

Abstract

Cysteine occupies a central position in plant metabolism because it is a reduced sulfur donor molecule involved in the synthesis of essential biomolecules and defense compounds. Moreover, cysteine per se and its derivative molecules play roles in the redox signaling of processes occurring in various cellular compartments. Cysteine is synthesized during the sulfate assimilation pathway via the incorporation of sulfide to O-acetylserine, catalyzed by O-acetylserine(thiol)lyase (OASTL). Plant cells contain OASTLs in the mitochondria, chloroplasts, and cytosol, resulting in a complex array of isoforms and subcellular cysteine pools. In recent years, significant progress has been made in Arabidopsis, in determining the specific roles of the OASTLs and the metabolites produced by them. Thus, the discovery of novel enzymatic activities of the less-abundant, like DES1 with L-cysteine desulfhydrase activity and SCS with S-sulfocysteine synthase activity, has provided new perspectives on their roles, besides their metabolic functions. Thereby, the research has been demonstrated that cytosolic sulfide and chloroplastic S-sulfocysteine act as signaling molecules regulating autophagy and protecting the photosystems, respectively. In the cytosol, cysteine plays an essential role in plant immunity; in the mitochondria, this molecule plays a central role in the detoxification of cyanide, which is essential for root hair development and plant responses to pathogens.

Authors+Show Affiliations

Instituto de Bioquímica Vegetal y Fotosíntesis, Consejo Superior de Investigaciones Científicas and Universidad de Sevilla, Avenida Américo Vespucio, 49, 41092 Sevilla, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24285094

Citation

Romero, Luis C., et al. "Cysteine and Cysteine-related Signaling Pathways in Arabidopsis Thaliana." Molecular Plant, vol. 7, no. 2, 2014, pp. 264-76.
Romero LC, Aroca MÁ, Laureano-Marín AM, et al. Cysteine and cysteine-related signaling pathways in Arabidopsis thaliana. Mol Plant. 2014;7(2):264-76.
Romero, L. C., Aroca, M. Á., Laureano-Marín, A. M., Moreno, I., García, I., & Gotor, C. (2014). Cysteine and cysteine-related signaling pathways in Arabidopsis thaliana. Molecular Plant, 7(2), pp. 264-76. doi:10.1093/mp/sst168.
Romero LC, et al. Cysteine and Cysteine-related Signaling Pathways in Arabidopsis Thaliana. Mol Plant. 2014;7(2):264-76. PubMed PMID: 24285094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cysteine and cysteine-related signaling pathways in Arabidopsis thaliana. AU - Romero,Luis C, AU - Aroca,M Ángeles, AU - Laureano-Marín,Ana M, AU - Moreno,Inmaculada, AU - García,Irene, AU - Gotor,Cecilia, Y1 - 2013/11/27/ PY - 2013/11/29/entrez PY - 2013/11/29/pubmed PY - 2014/7/23/medline KW - O-acetylserine(thiol)lyase KW - S-sulfocysteine synthase KW - cyanide KW - cysteine desulfhydrase KW - plant development KW - plant immunity KW - redox signaling KW - stress KW - sulfide. KW - β-cyanoalanine synthase SP - 264 EP - 76 JF - Molecular plant JO - Mol Plant VL - 7 IS - 2 N2 - Cysteine occupies a central position in plant metabolism because it is a reduced sulfur donor molecule involved in the synthesis of essential biomolecules and defense compounds. Moreover, cysteine per se and its derivative molecules play roles in the redox signaling of processes occurring in various cellular compartments. Cysteine is synthesized during the sulfate assimilation pathway via the incorporation of sulfide to O-acetylserine, catalyzed by O-acetylserine(thiol)lyase (OASTL). Plant cells contain OASTLs in the mitochondria, chloroplasts, and cytosol, resulting in a complex array of isoforms and subcellular cysteine pools. In recent years, significant progress has been made in Arabidopsis, in determining the specific roles of the OASTLs and the metabolites produced by them. Thus, the discovery of novel enzymatic activities of the less-abundant, like DES1 with L-cysteine desulfhydrase activity and SCS with S-sulfocysteine synthase activity, has provided new perspectives on their roles, besides their metabolic functions. Thereby, the research has been demonstrated that cytosolic sulfide and chloroplastic S-sulfocysteine act as signaling molecules regulating autophagy and protecting the photosystems, respectively. In the cytosol, cysteine plays an essential role in plant immunity; in the mitochondria, this molecule plays a central role in the detoxification of cyanide, which is essential for root hair development and plant responses to pathogens. SN - 1752-9867 UR - https://www.unboundmedicine.com/medline/citation/24285094/Cysteine_and_cysteine_related_signaling_pathways_in_Arabidopsis_thaliana_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1674-2052(14)60287-2 DB - PRIME DP - Unbound Medicine ER -