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Surelease or organic solution of ethylcellulose in preparation of sustained release theophylline micromatrices or matrices using spray drying technique.
Pharm Dev Technol. 2015 Mar; 20(2):204-10.PD

Abstract

This study evaluated ethylcellulose (EC) in two forms in preparation of sustained release theophylline microparticles using spray drying. Spray dried (SD) samples at different drug:polymer ratios were prepared using Surelease (SDaq) or organic solutions of ethylcellulose (SDor). Properties of particles (yield, particle morphology, size distribution and release profiles) were examined. Differential scanning calorimetry (DSC) and infrared spectroscopy (IR) studies were performed to track polymorphic changes and/or drug polymer interactions. SD samples were compressed and crushing strengths and release profiles were determined. The yields were in the range of 55-70%. The SD samples were nearly spherical with numerous fine particles attached to their surfaces. The SDor samples showed the smallest particle size. No polymorphism or drug-polymer interaction was observed. Uncompressed SDaq samples showed inadequate sustained release of drug compared to SDor samples. Surelease content did not affect drug release from SDaq samples. Tablets prepared from SDaq were softer and showed some plasticity, while those prepared from SDor exhibited higher crushing strengths. Tablets prepared from SDaq showed sustained release properties while the release of drug from compressed SDor samples were too slow. Overall Surelease was unable to sustain release of theophylline from SDaq microparticles, however, in compacted form showed more appropriate drug release than compacted SDor.

Authors+Show Affiliations

Pharmaceutical Research Center .No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24286215

Citation

Afrasiabi Garekani, Hadi, et al. "Surelease or Organic Solution of Ethylcellulose in Preparation of Sustained Release Theophylline Micromatrices or Matrices Using Spray Drying Technique." Pharmaceutical Development and Technology, vol. 20, no. 2, 2015, pp. 204-10.
Afrasiabi Garekani H, Sedighi S, Sadeghi F. Surelease or organic solution of ethylcellulose in preparation of sustained release theophylline micromatrices or matrices using spray drying technique. Pharm Dev Technol. 2015;20(2):204-10.
Afrasiabi Garekani, H., Sedighi, S., & Sadeghi, F. (2015). Surelease or organic solution of ethylcellulose in preparation of sustained release theophylline micromatrices or matrices using spray drying technique. Pharmaceutical Development and Technology, 20(2), 204-10. https://doi.org/10.3109/10837450.2013.860545
Afrasiabi Garekani H, Sedighi S, Sadeghi F. Surelease or Organic Solution of Ethylcellulose in Preparation of Sustained Release Theophylline Micromatrices or Matrices Using Spray Drying Technique. Pharm Dev Technol. 2015;20(2):204-10. PubMed PMID: 24286215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surelease or organic solution of ethylcellulose in preparation of sustained release theophylline micromatrices or matrices using spray drying technique. AU - Afrasiabi Garekani,Hadi, AU - Sedighi,Samira, AU - Sadeghi,Fatemeh, Y1 - 2013/11/29/ PY - 2013/11/30/entrez PY - 2013/11/30/pubmed PY - 2015/10/31/medline KW - Ethylcellulose KW - Surelease KW - spray drying KW - sustained release SP - 204 EP - 10 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 20 IS - 2 N2 - This study evaluated ethylcellulose (EC) in two forms in preparation of sustained release theophylline microparticles using spray drying. Spray dried (SD) samples at different drug:polymer ratios were prepared using Surelease (SDaq) or organic solutions of ethylcellulose (SDor). Properties of particles (yield, particle morphology, size distribution and release profiles) were examined. Differential scanning calorimetry (DSC) and infrared spectroscopy (IR) studies were performed to track polymorphic changes and/or drug polymer interactions. SD samples were compressed and crushing strengths and release profiles were determined. The yields were in the range of 55-70%. The SD samples were nearly spherical with numerous fine particles attached to their surfaces. The SDor samples showed the smallest particle size. No polymorphism or drug-polymer interaction was observed. Uncompressed SDaq samples showed inadequate sustained release of drug compared to SDor samples. Surelease content did not affect drug release from SDaq samples. Tablets prepared from SDaq were softer and showed some plasticity, while those prepared from SDor exhibited higher crushing strengths. Tablets prepared from SDaq showed sustained release properties while the release of drug from compressed SDor samples were too slow. Overall Surelease was unable to sustain release of theophylline from SDaq microparticles, however, in compacted form showed more appropriate drug release than compacted SDor. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/24286215/Surelease_or_organic_solution_of_ethylcellulose_in_preparation_of_sustained_release_theophylline_micromatrices_or_matrices_using_spray_drying_technique_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450.2013.860545 DB - PRIME DP - Unbound Medicine ER -