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Nocturnal polyuria and decreased serum testosterone: is there an association in men with lower urinary tract symptoms?
Int J Urol. 2014 May; 21(5):518-23.IJ

Abstract

OBJECTIVES

To investigate the putative association between nocturia and decreased serum testosterone in men with lower urinary tract symptoms.

METHODS

Frequency volume charts and serum testosterone levels of patients visiting the outpatient clinic for lower urinary tract symptoms were collected and analyzed. Age, prostate volume, body mass index and the presence of comorbidities were accounted for. Frequency volume charts were analyzed for pathophysiological components of nocturnal polyuria, global polyuria, decreased nocturnal bladder capacity and increased frequency to identify associated risks. Frequency volume charts were also used to chart 8-h changes of volume, frequency and capacity to identify time diurnal interactions with risk factors based on serum testosterone levels.

RESULTS

A total of 2180 patients were enrolled in the study. Multivariate analysis showed testosterone decreased 0.142 ng/mL for every increase in nocturia, independent of other factors. Logistic regression analysis showed a significant difference between pathophysiological components. Decreased testosterone was shown to carry a significant independent risk for overall nocturia (odds ratio 1.60, 95% confidence interval 1.013-2.527, P = 0.044), and particularly nocturnal polyuria (odds ratio 1.934, 95% confidence interval 1.001-3.737, P = 0.027). Repeated measurement models showed patients with serum testosterone below 2.50 ng/mL to have a paradoxical increase in nocturnal urine volume at night.

CONCLUSIONS

Nocturia, especially nocturnal polyuria, is associated with decreased serum testosterone. Patients with low serum testosterone show increased nocturnal urine output.

Authors+Show Affiliations

Department of Urology, Korea University Medical Center Guro Hospital, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24286364

Citation

Kim, Jin Wook, et al. "Nocturnal Polyuria and Decreased Serum Testosterone: Is There an Association in Men With Lower Urinary Tract Symptoms?" International Journal of Urology : Official Journal of the Japanese Urological Association, vol. 21, no. 5, 2014, pp. 518-23.
Kim JW, Oh MM, Yoon CY, et al. Nocturnal polyuria and decreased serum testosterone: is there an association in men with lower urinary tract symptoms? Int J Urol. 2014;21(5):518-23.
Kim, J. W., Oh, M. M., Yoon, C. Y., Bae, J. H., Kim, J. J., & Moon, d. u. . G. (2014). Nocturnal polyuria and decreased serum testosterone: is there an association in men with lower urinary tract symptoms? International Journal of Urology : Official Journal of the Japanese Urological Association, 21(5), 518-23. https://doi.org/10.1111/iju.12345
Kim JW, et al. Nocturnal Polyuria and Decreased Serum Testosterone: Is There an Association in Men With Lower Urinary Tract Symptoms. Int J Urol. 2014;21(5):518-23. PubMed PMID: 24286364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nocturnal polyuria and decreased serum testosterone: is there an association in men with lower urinary tract symptoms? AU - Kim,Jin Wook, AU - Oh,Mi Mi, AU - Yoon,Cheol Yong, AU - Bae,Jae Hyun, AU - Kim,Je Jong, AU - Moon,Du Geon, Y1 - 2013/11/28/ PY - 2013/04/10/received PY - 2013/10/14/accepted PY - 2013/11/30/entrez PY - 2013/11/30/pubmed PY - 2014/12/23/medline KW - lower urinary tract symptoms KW - nocturia KW - nocturnal polyuria KW - testosterone SP - 518 EP - 23 JF - International journal of urology : official journal of the Japanese Urological Association JO - Int. J. Urol. VL - 21 IS - 5 N2 - OBJECTIVES: To investigate the putative association between nocturia and decreased serum testosterone in men with lower urinary tract symptoms. METHODS: Frequency volume charts and serum testosterone levels of patients visiting the outpatient clinic for lower urinary tract symptoms were collected and analyzed. Age, prostate volume, body mass index and the presence of comorbidities were accounted for. Frequency volume charts were analyzed for pathophysiological components of nocturnal polyuria, global polyuria, decreased nocturnal bladder capacity and increased frequency to identify associated risks. Frequency volume charts were also used to chart 8-h changes of volume, frequency and capacity to identify time diurnal interactions with risk factors based on serum testosterone levels. RESULTS: A total of 2180 patients were enrolled in the study. Multivariate analysis showed testosterone decreased 0.142 ng/mL for every increase in nocturia, independent of other factors. Logistic regression analysis showed a significant difference between pathophysiological components. Decreased testosterone was shown to carry a significant independent risk for overall nocturia (odds ratio 1.60, 95% confidence interval 1.013-2.527, P = 0.044), and particularly nocturnal polyuria (odds ratio 1.934, 95% confidence interval 1.001-3.737, P = 0.027). Repeated measurement models showed patients with serum testosterone below 2.50 ng/mL to have a paradoxical increase in nocturnal urine volume at night. CONCLUSIONS: Nocturia, especially nocturnal polyuria, is associated with decreased serum testosterone. Patients with low serum testosterone show increased nocturnal urine output. SN - 1442-2042 UR - https://www.unboundmedicine.com/medline/citation/24286364/Nocturnal_polyuria_and_decreased_serum_testosterone:_is_there_an_association_in_men_with_lower_urinary_tract_symptoms L2 - https://doi.org/10.1111/iju.12345 DB - PRIME DP - Unbound Medicine ER -