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Can chemokines be used as biomarkers for endometriosis? A systematic review.

Abstract

STUDY QUESTION

Can we use chemokines as biomarkers to diagnose patients with endometriosis in clinical practice?

SUMMARY ANSWER

Some chemokines, especially CXCL8 (IL-8), CCL-2 (MCP-1) and CCL5 (RANTES), have the potential to work as biomarkers to identify patients with endometriosis but their accuracy could be improved by combination with other non-inflammatory markers in a panel of biomarkers.

WHAT IS ALREADY KNOWN

The need for a good marker to diagnose endometriosis has increased in recent years and research in this field has intensified. Chemokines have been reported to be associated with endometriosis in several studies over the last 20 years. Many of these studies measured one or more chemokines in peritoneal fluid (PF) and peripheral blood (PB) or through endometrial biopsies in patients with and without endometriosis.

STUDY DESIGN, SIZE, DURATION

A systematic review was done on all published studies that compared chemokine concentrations in patients with and without endometriosis to evaluate their potential as biomarkers for the disease.

PARTICIPANTS/MATERIALS, SETTING, METHODS

Using MEDLINE database from December 1993 to August 2013 and the MeSH terms 'Endometriosis' and 'Chemokines', we identified relevant studies to include in the present review, which was based on the PRISMA statement. Studies that measured at least one chemokine in patients with endometriosis and matching controls in PB, PF or endometrial samples were included. We did not include samples from ectopic lesions. All review articles as well as studies with animals and those not written in English were excluded from this systematic review. The studies were assessed using a modified version of the Quality Assessment of Diagnostic Accuracy Studies criteria. Two authors independently assessed studies for inclusion and risk of bias, and extracted data.

MAIN RESULTS AND THE ROLE OF CHANCE

After inclusion and exclusion criteria, 62 studies were selected to be included in this systematic review. A total of 27 different chemokines or their receptors were evaluated in the reviewed studies. The most studied chemokines (including their receptors) were CXCL8 (51.6%), CCL2 (38.7%) and CCL5 (19.3%) (% of studies). CXCL8 (IL-8) appears to have the best results among all the other chemokines as a marker for endometriosis.

LIMITATIONS, REASONS FOR CAUTION

Some studies included have low power due to small sample size and study designs vary in the assessment criteria for the markers, the state of the patients (e.g. phase of the cycle and stage of disease) and the nature of the controls.

WIDER IMPLICATIONS OF THE FINDINGS

Our findings could guide future research in this field to select the chemokines with the best potential, and to stimulate better-designed studies to determine whether they can become a useful diagnostic tool in clinical practice.

STUDY FUNDING/COMPETING INTEREST(S)

There was no funding to support this systematic review. The authors have no competing interest to declare.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Gynecology, Charité, Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.

    ,

    Source

    Human reproduction (Oxford, England) 29:2 2014 Feb pg 253-66

    MeSH

    Ascitic Fluid
    Biomarkers
    Chemokine CCL2
    Chemokine CCL5
    Chemokines
    Endometriosis
    Endometrium
    Female
    Humans
    Inflammation
    Interleukin-8

    Pub Type(s)

    Journal Article
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    24287816

    Citation

    Borrelli, G M., et al. "Can Chemokines Be Used as Biomarkers for Endometriosis? a Systematic Review." Human Reproduction (Oxford, England), vol. 29, no. 2, 2014, pp. 253-66.
    Borrelli GM, Abrão MS, Mechsner S. Can chemokines be used as biomarkers for endometriosis? A systematic review. Hum Reprod. 2014;29(2):253-66.
    Borrelli, G. M., Abrão, M. S., & Mechsner, S. (2014). Can chemokines be used as biomarkers for endometriosis? A systematic review. Human Reproduction (Oxford, England), 29(2), pp. 253-66. doi:10.1093/humrep/det401.
    Borrelli GM, Abrão MS, Mechsner S. Can Chemokines Be Used as Biomarkers for Endometriosis? a Systematic Review. Hum Reprod. 2014;29(2):253-66. PubMed PMID: 24287816.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Can chemokines be used as biomarkers for endometriosis? A systematic review. AU - Borrelli,G M, AU - Abrão,M S, AU - Mechsner,S, Y1 - 2013/11/27/ PY - 2013/11/30/entrez PY - 2013/11/30/pubmed PY - 2014/9/30/medline KW - biomarkers KW - chemokines KW - endometriosis SP - 253 EP - 66 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 29 IS - 2 N2 - STUDY QUESTION: Can we use chemokines as biomarkers to diagnose patients with endometriosis in clinical practice? SUMMARY ANSWER: Some chemokines, especially CXCL8 (IL-8), CCL-2 (MCP-1) and CCL5 (RANTES), have the potential to work as biomarkers to identify patients with endometriosis but their accuracy could be improved by combination with other non-inflammatory markers in a panel of biomarkers. WHAT IS ALREADY KNOWN: The need for a good marker to diagnose endometriosis has increased in recent years and research in this field has intensified. Chemokines have been reported to be associated with endometriosis in several studies over the last 20 years. Many of these studies measured one or more chemokines in peritoneal fluid (PF) and peripheral blood (PB) or through endometrial biopsies in patients with and without endometriosis. STUDY DESIGN, SIZE, DURATION: A systematic review was done on all published studies that compared chemokine concentrations in patients with and without endometriosis to evaluate their potential as biomarkers for the disease. PARTICIPANTS/MATERIALS, SETTING, METHODS: Using MEDLINE database from December 1993 to August 2013 and the MeSH terms 'Endometriosis' and 'Chemokines', we identified relevant studies to include in the present review, which was based on the PRISMA statement. Studies that measured at least one chemokine in patients with endometriosis and matching controls in PB, PF or endometrial samples were included. We did not include samples from ectopic lesions. All review articles as well as studies with animals and those not written in English were excluded from this systematic review. The studies were assessed using a modified version of the Quality Assessment of Diagnostic Accuracy Studies criteria. Two authors independently assessed studies for inclusion and risk of bias, and extracted data. MAIN RESULTS AND THE ROLE OF CHANCE: After inclusion and exclusion criteria, 62 studies were selected to be included in this systematic review. A total of 27 different chemokines or their receptors were evaluated in the reviewed studies. The most studied chemokines (including their receptors) were CXCL8 (51.6%), CCL2 (38.7%) and CCL5 (19.3%) (% of studies). CXCL8 (IL-8) appears to have the best results among all the other chemokines as a marker for endometriosis. LIMITATIONS, REASONS FOR CAUTION: Some studies included have low power due to small sample size and study designs vary in the assessment criteria for the markers, the state of the patients (e.g. phase of the cycle and stage of disease) and the nature of the controls. WIDER IMPLICATIONS OF THE FINDINGS: Our findings could guide future research in this field to select the chemokines with the best potential, and to stimulate better-designed studies to determine whether they can become a useful diagnostic tool in clinical practice. STUDY FUNDING/COMPETING INTEREST(S): There was no funding to support this systematic review. The authors have no competing interest to declare. SN - 1460-2350 UR - https://www.unboundmedicine.com/medline/citation/24287816/Can_chemokines_be_used_as_biomarkers_for_endometriosis_A_systematic_review_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/det401 DB - PRIME DP - Unbound Medicine ER -