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Seminal, clinical and colour-Doppler ultrasound correlations of prostatitis-like symptoms in males of infertile couples.
Andrology. 2014 Jan; 2(1):30-41.A

Abstract

'Prostatitis-like symptoms' (PLS) are a cluster of bothersome conditions defined as 'perineal and/or ejaculatory pain or discomfort and National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) pain subdomain score ≥4' (Nickel's criteria). PLS may originate from the prostate or from other portions of the male genital tract. Although PLS could be associated with 'prostatitis', they should not be confused. The NIH-CPSI is considered the gold-standard for assessing PLS severity. Although previous studies investigated the impact of prostatitis, vesiculitis or epididymitis on semen parameters, correlations between their related symptoms and seminal or scrotal/transrectal colour-Doppler ultrasound (CDU) characteristics have not been carefully determined. And no previous study evaluated the CDU features of PLS in infertile men. This study was aimed at investigating possible associations among NIH-CPSI (total and subdomain) scores and PLS, with seminal, clinical and scrotal/transrectal CDU parameters in a cohort of males of infertile couples. PLS of 400 men (35.8 ± 7.2 years) with a suspected male factor were assessed by the NIH-CPSI. All patients underwent, during the same day, semen analysis, seminal plasma interleukin 8 (sIL-8, a marker of male genital tract inflammation), biochemical evaluation, urine/seminal cultures, scrotal/transrectal CDU. PLS was detected in 39 (9.8%) subjects. After adjusting for age, waist and total testosterone (TT), no association among NIH-CPSI (total or subdomain) scores or PLS and sperm parameters was observed. However, we found a positive association with current positive urine and/or seminal cultures, sIL-8 levels and CDU features suggestive of inflammation of the epididymis, seminal vesicles, prostate, but not of the testis. The aforementioned significant associations of PLS were further confirmed by comparing PLS patients with age-, waist- and TT-matched PLS-free patients (1 : 3 ratio). In conclusion, NIH-CPSI scores and PLS evaluated in males of infertile couples, are not related to sperm parameters, but mainly to clinical and CDU signs of infection/inflammation.

Authors+Show Affiliations

Sexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24288243

Citation

Lotti, F, et al. "Seminal, Clinical and colour-Doppler Ultrasound Correlations of Prostatitis-like Symptoms in Males of Infertile Couples." Andrology, vol. 2, no. 1, 2014, pp. 30-41.
Lotti F, Corona G, Mondaini N, et al. Seminal, clinical and colour-Doppler ultrasound correlations of prostatitis-like symptoms in males of infertile couples. Andrology. 2014;2(1):30-41.
Lotti, F., Corona, G., Mondaini, N., Maseroli, E., Rossi, M., Filimberti, E., Noci, I., Forti, G., & Maggi, M. (2014). Seminal, clinical and colour-Doppler ultrasound correlations of prostatitis-like symptoms in males of infertile couples. Andrology, 2(1), 30-41. https://doi.org/10.1111/j.2047-2927.2013.00156.x
Lotti F, et al. Seminal, Clinical and colour-Doppler Ultrasound Correlations of Prostatitis-like Symptoms in Males of Infertile Couples. Andrology. 2014;2(1):30-41. PubMed PMID: 24288243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seminal, clinical and colour-Doppler ultrasound correlations of prostatitis-like symptoms in males of infertile couples. AU - Lotti,F, AU - Corona,G, AU - Mondaini,N, AU - Maseroli,E, AU - Rossi,M, AU - Filimberti,E, AU - Noci,I, AU - Forti,G, AU - Maggi,M, Y1 - 2013/11/28/ PY - 2013/07/23/received PY - 2013/10/10/revised PY - 2013/10/11/accepted PY - 2013/11/30/entrez PY - 2013/11/30/pubmed PY - 2014/9/10/medline KW - National Institutes of Health-Chronic Prostatitis Symptom Index KW - male infertility KW - prostatitis-like symptoms KW - scrotal and transrectal colour-Doppler ultrasound KW - seminal and laboratory parameters SP - 30 EP - 41 JF - Andrology JO - Andrology VL - 2 IS - 1 N2 - 'Prostatitis-like symptoms' (PLS) are a cluster of bothersome conditions defined as 'perineal and/or ejaculatory pain or discomfort and National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) pain subdomain score ≥4' (Nickel's criteria). PLS may originate from the prostate or from other portions of the male genital tract. Although PLS could be associated with 'prostatitis', they should not be confused. The NIH-CPSI is considered the gold-standard for assessing PLS severity. Although previous studies investigated the impact of prostatitis, vesiculitis or epididymitis on semen parameters, correlations between their related symptoms and seminal or scrotal/transrectal colour-Doppler ultrasound (CDU) characteristics have not been carefully determined. And no previous study evaluated the CDU features of PLS in infertile men. This study was aimed at investigating possible associations among NIH-CPSI (total and subdomain) scores and PLS, with seminal, clinical and scrotal/transrectal CDU parameters in a cohort of males of infertile couples. PLS of 400 men (35.8 ± 7.2 years) with a suspected male factor were assessed by the NIH-CPSI. All patients underwent, during the same day, semen analysis, seminal plasma interleukin 8 (sIL-8, a marker of male genital tract inflammation), biochemical evaluation, urine/seminal cultures, scrotal/transrectal CDU. PLS was detected in 39 (9.8%) subjects. After adjusting for age, waist and total testosterone (TT), no association among NIH-CPSI (total or subdomain) scores or PLS and sperm parameters was observed. However, we found a positive association with current positive urine and/or seminal cultures, sIL-8 levels and CDU features suggestive of inflammation of the epididymis, seminal vesicles, prostate, but not of the testis. The aforementioned significant associations of PLS were further confirmed by comparing PLS patients with age-, waist- and TT-matched PLS-free patients (1 : 3 ratio). In conclusion, NIH-CPSI scores and PLS evaluated in males of infertile couples, are not related to sperm parameters, but mainly to clinical and CDU signs of infection/inflammation. SN - 2047-2927 UR - https://www.unboundmedicine.com/medline/citation/24288243/Seminal_clinical_and_colour_Doppler_ultrasound_correlations_of_prostatitis_like_symptoms_in_males_of_infertile_couples_ L2 - https://doi.org/10.1111/j.2047-2927.2013.00156.x DB - PRIME DP - Unbound Medicine ER -