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Systemic administration of Rosmarinus officinalis attenuates the inflammatory response induced by carrageenan in the mouse model of pleurisy.
Planta Med. 2013 Nov; 79(17):1605-14.PM

Abstract

Rosmarinus officinalis, also named rosemary, is a native plant from the Mediterranean region that is useful for the treatment of inflammatory diseases. Studies using experimental models and/or in vitro tests have shown the important biological effects of rosemary. In this context, the mechanism of the anti-inflammatory activity of rosemary must be investigated to support the discovery of new substances with anti-inflammatory effects. The aim of the present study was to investigate the anti-inflammatory effects of crude extract oil free obtained from the leaves of rosemary in an animal model of inflammation, thus evaluating its medicinal use for the treatment of inflammatory conditions. Also its ethanol, hexane, and ethyl acetate fractions, as well as its isolated compounds carnosol and rosmarinic acid were analyzed. Swiss mice were used for the in vivo experiments. The effect of this herb on the inhibition of the leukocytes, exudation, myeloperoxidase, and adenosine-deaminase activities, nitrite/nitrate, interleukin 17A, and interleukin 10 levels and mRNA expression was determined. The crude extract and its derived fractions, in addition to its isolated compounds, inhibited leukocytes and decreased exudation and myeloperoxidase and adenosine-deaminase activities, as well as nitrite/nitrate and interleukin 17A levels and mRNA expression, besides increasing interleukin 10 levels and mRNA expression. Rosemary showed important anti-inflammatory activity by inhibiting leukocytes and decreasing exudation. These effects were associated with a decrease in the proinflammatory parameters (myeloperoxidase, adenosine-deaminase, nitrite/nitrate, and interleukin 17A) and an increase in the anti-inflammatory cytokine (interleukin 10). This study confirms the anti-inflammatory properties of rosemary and validates its use in folk medicine to treat inflammatory diseases such as rheumatism and asthma.

Authors+Show Affiliations

Department of Clinical Analysis, Centre for Health Sciences, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24288274

Citation

da Rosa, Julia Salvan, et al. "Systemic Administration of Rosmarinus Officinalis Attenuates the Inflammatory Response Induced By Carrageenan in the Mouse Model of Pleurisy." Planta Medica, vol. 79, no. 17, 2013, pp. 1605-14.
da Rosa JS, Facchin BM, Bastos J, et al. Systemic administration of Rosmarinus officinalis attenuates the inflammatory response induced by carrageenan in the mouse model of pleurisy. Planta Med. 2013;79(17):1605-14.
da Rosa, J. S., Facchin, B. M., Bastos, J., Siqueira, M. A., Micke, G. A., Dalmarco, E. M., Pizzolatti, M. G., & Fröde, T. S. (2013). Systemic administration of Rosmarinus officinalis attenuates the inflammatory response induced by carrageenan in the mouse model of pleurisy. Planta Medica, 79(17), 1605-14. https://doi.org/10.1055/s-0033-1351018
da Rosa JS, et al. Systemic Administration of Rosmarinus Officinalis Attenuates the Inflammatory Response Induced By Carrageenan in the Mouse Model of Pleurisy. Planta Med. 2013;79(17):1605-14. PubMed PMID: 24288274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systemic administration of Rosmarinus officinalis attenuates the inflammatory response induced by carrageenan in the mouse model of pleurisy. AU - da Rosa,Julia Salvan, AU - Facchin,Bruno Matheus, AU - Bastos,Juliana, AU - Siqueira,Mariana Araújo, AU - Micke,Gustavo Amadeu, AU - Dalmarco,Eduardo Monguilhott, AU - Pizzolatti,Moacir Geraldo, AU - Fröde,Tânia Silvia, Y1 - 2013/11/28/ PY - 2013/11/30/entrez PY - 2013/11/30/pubmed PY - 2014/7/11/medline SP - 1605 EP - 14 JF - Planta medica JO - Planta Med. VL - 79 IS - 17 N2 - Rosmarinus officinalis, also named rosemary, is a native plant from the Mediterranean region that is useful for the treatment of inflammatory diseases. Studies using experimental models and/or in vitro tests have shown the important biological effects of rosemary. In this context, the mechanism of the anti-inflammatory activity of rosemary must be investigated to support the discovery of new substances with anti-inflammatory effects. The aim of the present study was to investigate the anti-inflammatory effects of crude extract oil free obtained from the leaves of rosemary in an animal model of inflammation, thus evaluating its medicinal use for the treatment of inflammatory conditions. Also its ethanol, hexane, and ethyl acetate fractions, as well as its isolated compounds carnosol and rosmarinic acid were analyzed. Swiss mice were used for the in vivo experiments. The effect of this herb on the inhibition of the leukocytes, exudation, myeloperoxidase, and adenosine-deaminase activities, nitrite/nitrate, interleukin 17A, and interleukin 10 levels and mRNA expression was determined. The crude extract and its derived fractions, in addition to its isolated compounds, inhibited leukocytes and decreased exudation and myeloperoxidase and adenosine-deaminase activities, as well as nitrite/nitrate and interleukin 17A levels and mRNA expression, besides increasing interleukin 10 levels and mRNA expression. Rosemary showed important anti-inflammatory activity by inhibiting leukocytes and decreasing exudation. These effects were associated with a decrease in the proinflammatory parameters (myeloperoxidase, adenosine-deaminase, nitrite/nitrate, and interleukin 17A) and an increase in the anti-inflammatory cytokine (interleukin 10). This study confirms the anti-inflammatory properties of rosemary and validates its use in folk medicine to treat inflammatory diseases such as rheumatism and asthma. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/24288274/Systemic_administration_of_Rosmarinus_officinalis_attenuates_the_inflammatory_response_induced_by_carrageenan_in_the_mouse_model_of_pleurisy_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0033-1351018 DB - PRIME DP - Unbound Medicine ER -