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Relationship between oxidized LDL, IgM, and IgG autoantibodies to ox-LDL levels with recurrent cardiovascular events in Swedish patients with previous myocardial infarction.
Angiology. 2014 Nov; 65(10):932-6.A

Abstract

We determined whether plasma levels of circulating oxidized low-density lipoprotein (LDL; E06), immunoglobulin (Ig) G, and IgM autoantibodies binding to malonyldialdehyde-modified LDL (MDA-LDL) may predict cardiovascular events (CVEs). Patients (n=123) with a previous myocardial infarction (MI) were included. The primary end point was defined as any of the following: cardiovascular death from any cause, nonfatal reinfarction or stroke, percutaneous coronary intervention, coronary artery bypass grafting, and hospitalization due to angina pectoris. There were 43 CVEs during the follow-up period of 8.4±3.5 years. There was no significant difference in the levels of E06 and MDA-LDL IgG between the CVE and the event-free group. However, MDA-LDL IgM levels were significantly lower in patients in the CVE group (9524±6326 relative light unit [RLU]) compared with the event-free (10,975±5398 RLU) group (P=.04). In conclusion, levels of MDA-LDL IgM were associated with an increased risk of CVE in patients with a previous MI.

Authors+Show Affiliations

Department of Neurobiology, Caring Sciences and Society, Division of Geriatric Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Solna, Sweden.Department of Cardiology, Karolinska University Hospital, Huddinge, Karolinska Institute, Solna, Sweden.Department of Cardiology, Oslo University Hospital, Ullevål and Institute of Clinical Medicine, University of Oslo, Oslo, Norway stefan.agewall@medisin.uio.no.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24288363

Citation

Crisby, M, et al. "Relationship Between Oxidized LDL, IgM, and IgG Autoantibodies to ox-LDL Levels With Recurrent Cardiovascular Events in Swedish Patients With Previous Myocardial Infarction." Angiology, vol. 65, no. 10, 2014, pp. 932-6.
Crisby M, Henareh L, Agewall S. Relationship between oxidized LDL, IgM, and IgG autoantibodies to ox-LDL levels with recurrent cardiovascular events in Swedish patients with previous myocardial infarction. Angiology. 2014;65(10):932-6.
Crisby, M., Henareh, L., & Agewall, S. (2014). Relationship between oxidized LDL, IgM, and IgG autoantibodies to ox-LDL levels with recurrent cardiovascular events in Swedish patients with previous myocardial infarction. Angiology, 65(10), 932-6. https://doi.org/10.1177/0003319713512720
Crisby M, Henareh L, Agewall S. Relationship Between Oxidized LDL, IgM, and IgG Autoantibodies to ox-LDL Levels With Recurrent Cardiovascular Events in Swedish Patients With Previous Myocardial Infarction. Angiology. 2014;65(10):932-6. PubMed PMID: 24288363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between oxidized LDL, IgM, and IgG autoantibodies to ox-LDL levels with recurrent cardiovascular events in Swedish patients with previous myocardial infarction. AU - Crisby,M, AU - Henareh,L, AU - Agewall,Stefan, Y1 - 2013/11/27/ PY - 2013/11/30/entrez PY - 2013/11/30/pubmed PY - 2014/12/19/medline KW - IgM and IgG MDA-LDL autoantibodies KW - biomarkers KW - cardiovascular events KW - myocardial infarction KW - oxidized LDL SP - 932 EP - 6 JF - Angiology JO - Angiology VL - 65 IS - 10 N2 - We determined whether plasma levels of circulating oxidized low-density lipoprotein (LDL; E06), immunoglobulin (Ig) G, and IgM autoantibodies binding to malonyldialdehyde-modified LDL (MDA-LDL) may predict cardiovascular events (CVEs). Patients (n=123) with a previous myocardial infarction (MI) were included. The primary end point was defined as any of the following: cardiovascular death from any cause, nonfatal reinfarction or stroke, percutaneous coronary intervention, coronary artery bypass grafting, and hospitalization due to angina pectoris. There were 43 CVEs during the follow-up period of 8.4±3.5 years. There was no significant difference in the levels of E06 and MDA-LDL IgG between the CVE and the event-free group. However, MDA-LDL IgM levels were significantly lower in patients in the CVE group (9524±6326 relative light unit [RLU]) compared with the event-free (10,975±5398 RLU) group (P=.04). In conclusion, levels of MDA-LDL IgM were associated with an increased risk of CVE in patients with a previous MI. SN - 1940-1574 UR - https://www.unboundmedicine.com/medline/citation/24288363/Relationship_between_oxidized_LDL_IgM_and_IgG_autoantibodies_to_ox_LDL_levels_with_recurrent_cardiovascular_events_in_Swedish_patients_with_previous_myocardial_infarction_ L2 - http://journals.sagepub.com/doi/full/10.1177/0003319713512720?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -