Tags

Type your tag names separated by a space and hit enter

A new flavonol glycoside and biological activities of Adenanthera pavonina L. leaves.
Nat Prod Res. 2014; 28(5):282-9.NP

Abstract

Adenanthera pavonina is a plant belonging to family Fabaceae. The 95% ethanol extract (EtOH) of the dried powdered leaves of the plant and successive extracts with solvents of increasing polarities were prepared. Fractionation of the successive aqueous EtOH extract on polyamide column and purification of the isolated compounds on Sephadex LH20 led to the isolation of a new methoxy flavonol glycoside named as quercetin 3-O-α-dirhamnopyranosyl-(1‴ → 2″,1″″ → 6″)-β-glucopyranoside-4'-methoxy (1), as well as kaempferol-3-O-α-dirhamnopyranosyl-(1‴ → 2″,1″″ → 6″)-β-glucopyranoside (2), isovitexin (3), quercetin-3-O-rhamnopyranosyl(1‴ → 4″)-β-glucopyranoside (4), quercetin-3-O-β-glucopranoside-4'-O-rhamnopyranoside (5), kaempferol-3-O-α-rhamnopyranosyl(1‴ → 2″)-β-glucopyranoside (6), quercetin-3-O-rhamnopyranosyl(1‴ → 2″)-β-glucopyranoside (7), quercetin-3-O-β-glucopyranoside (8), kaempferol (9) and quercetin (10). Structures of the isolated compounds were established by spectroscopic analysis. Antioxidant activities of EtOH extract, successive extracts and compounds 1 and 2 were evaluated. The ethyl acetate (EtOAc) extract and EtOH extract showed 62.67% and 49.30% free radical scavenging activity, respectively. Cytotoxic activities of the EtOH extract and compounds (1) and (2) were evaluated. The EtOH extract showed a significant cytotoxic activity against Hep G-2 (IC50 = 2.50 μg) as compared with cisplatin (IC50>10 μg).

Authors+Show Affiliations

a Pharmacognosy Department , National Research Centre , El-Tahrir St., Dokki, Cairo 12622 , Egypt.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24289202

Citation

Mohammed, R S., et al. "A New Flavonol Glycoside and Biological Activities of Adenanthera Pavonina L. Leaves." Natural Product Research, vol. 28, no. 5, 2014, pp. 282-9.
Mohammed RS, Abou Zeid AH, El-Kashoury EA, et al. A new flavonol glycoside and biological activities of Adenanthera pavonina L. leaves. Nat Prod Res. 2014;28(5):282-9.
Mohammed, R. S., Abou Zeid, A. H., El-Kashoury, E. A., Sleem, A. A., & Waly, D. A. (2014). A new flavonol glycoside and biological activities of Adenanthera pavonina L. leaves. Natural Product Research, 28(5), 282-9. https://doi.org/10.1080/14786419.2013.856903
Mohammed RS, et al. A New Flavonol Glycoside and Biological Activities of Adenanthera Pavonina L. Leaves. Nat Prod Res. 2014;28(5):282-9. PubMed PMID: 24289202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new flavonol glycoside and biological activities of Adenanthera pavonina L. leaves. AU - Mohammed,R S, AU - Abou Zeid,A H, AU - El-Kashoury,E A, AU - Sleem,A A, AU - Waly,D A, Y1 - 2013/11/29/ PY - 2013/12/3/entrez PY - 2013/12/3/pubmed PY - 2014/9/11/medline SP - 282 EP - 9 JF - Natural product research JO - Nat Prod Res VL - 28 IS - 5 N2 - Adenanthera pavonina is a plant belonging to family Fabaceae. The 95% ethanol extract (EtOH) of the dried powdered leaves of the plant and successive extracts with solvents of increasing polarities were prepared. Fractionation of the successive aqueous EtOH extract on polyamide column and purification of the isolated compounds on Sephadex LH20 led to the isolation of a new methoxy flavonol glycoside named as quercetin 3-O-α-dirhamnopyranosyl-(1‴ → 2″,1″″ → 6″)-β-glucopyranoside-4'-methoxy (1), as well as kaempferol-3-O-α-dirhamnopyranosyl-(1‴ → 2″,1″″ → 6″)-β-glucopyranoside (2), isovitexin (3), quercetin-3-O-rhamnopyranosyl(1‴ → 4″)-β-glucopyranoside (4), quercetin-3-O-β-glucopranoside-4'-O-rhamnopyranoside (5), kaempferol-3-O-α-rhamnopyranosyl(1‴ → 2″)-β-glucopyranoside (6), quercetin-3-O-rhamnopyranosyl(1‴ → 2″)-β-glucopyranoside (7), quercetin-3-O-β-glucopyranoside (8), kaempferol (9) and quercetin (10). Structures of the isolated compounds were established by spectroscopic analysis. Antioxidant activities of EtOH extract, successive extracts and compounds 1 and 2 were evaluated. The ethyl acetate (EtOAc) extract and EtOH extract showed 62.67% and 49.30% free radical scavenging activity, respectively. Cytotoxic activities of the EtOH extract and compounds (1) and (2) were evaluated. The EtOH extract showed a significant cytotoxic activity against Hep G-2 (IC50 = 2.50 μg) as compared with cisplatin (IC50>10 μg). SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/24289202/A_new_flavonol_glycoside_and_biological_activities_of_Adenanthera_pavonina_L__leaves_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2013.856903 DB - PRIME DP - Unbound Medicine ER -