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Defining a cutoff point for vitamin D deficiency based on insulin resistance in children.
Diabetes Metab Syndr. 2013 Oct-Dec; 7(4):210-3.DM

Abstract

BACKGROUND

Vitamin D deficiency is a common worldwide problem. Low levels of serum 25-hydroxy vitamin D [25(OH)D], as a marker of vitamin D deficiency, have been linked to a wide field of health problems, including metabolic diseases such as insulin resistance, type 1 and type 2 DM. There is no universal definition for cutoff value of vitamin D deficiency and it seems that it varies in different populations.

OBJECTIVE

Most previous studies have used a start rise of PTH as a criteria to detect threshold of serum 25(OH)D, However, the aim of this study was to determine a cutoff point of serum 25(OH)D for vitamin D deficiency based on HOMA-IR.

MATERIALS AND METHODS

Two hundred and ninety seven healthy children (aged 7-11 years) were enrolled. Serum 25(OH)D and PTH were measured and HOMA-IR was calculated. The ROC curve was utilized to obtain a cutoff of vitamin D deficiency based on HOMA-IR.

RESULTS

25(OH)D concentrations were inversely correlated with HOMA-IR levels (Spearman's r=-0.14, p=0.016). Serum 25(OH)D cutoff point was 11.6ng/mL (29nmol/L) in relation with HOMA-IR >2.1. By using this cutoff value, the prevalence of vitamin D deficiency was 43.4% in this study population of healthy children.

CONCLUSION

We found that serum 25(OH)D levels are inversely associated with insulin resistance. These results suggest that in MetS patients it may benefit to determine cutoff value of 25(OH)D levels based on HOMA-IR.

Authors+Show Affiliations

Clinical Endocrinology, Zanjan Metabolic Disease Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24290086

Citation

Sharifi, Faranak, et al. "Defining a Cutoff Point for Vitamin D Deficiency Based On Insulin Resistance in Children." Diabetes & Metabolic Syndrome, vol. 7, no. 4, 2013, pp. 210-3.
Sharifi F, Mousavinasab N, Mellati AA. Defining a cutoff point for vitamin D deficiency based on insulin resistance in children. Diabetes Metab Syndr. 2013;7(4):210-3.
Sharifi, F., Mousavinasab, N., & Mellati, A. A. (2013). Defining a cutoff point for vitamin D deficiency based on insulin resistance in children. Diabetes & Metabolic Syndrome, 7(4), 210-3. https://doi.org/10.1016/j.dsx.2013.10.015
Sharifi F, Mousavinasab N, Mellati AA. Defining a Cutoff Point for Vitamin D Deficiency Based On Insulin Resistance in Children. Diabetes Metab Syndr. 2013 Oct-Dec;7(4):210-3. PubMed PMID: 24290086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Defining a cutoff point for vitamin D deficiency based on insulin resistance in children. AU - Sharifi,Faranak, AU - Mousavinasab,Nouraddin, AU - Mellati,Ali Awsat, Y1 - 2013/11/13/ PY - 2013/12/3/entrez PY - 2013/12/3/pubmed PY - 2014/8/13/medline KW - 25(OH)D KW - 25-Hydroxy vitamin D concentration KW - 25-hydroxy vitamin D KW - BMI KW - BP KW - Children KW - Cutoff point KW - ECLIA KW - FBS KW - FPG KW - GPs KW - HOMA-IR KW - HPMA-IR KW - IR KW - Insulin resistance KW - MetS KW - PTH KW - ROC curve KW - Vitamin D deficiency KW - WC KW - blood pressure KW - body mass index KW - electrochemiluminescence KW - fast blood sugar KW - fasting plasma glucose KW - general practitioners KW - homeostatic model assessment KW - iPTH KW - insulin resistance KW - intact parathyroid hormone KW - metabolic syndrome KW - parathyroid hormone KW - receiver operating characteristic curve KW - waist circumference SP - 210 EP - 3 JF - Diabetes & metabolic syndrome JO - Diabetes Metab Syndr VL - 7 IS - 4 N2 - BACKGROUND: Vitamin D deficiency is a common worldwide problem. Low levels of serum 25-hydroxy vitamin D [25(OH)D], as a marker of vitamin D deficiency, have been linked to a wide field of health problems, including metabolic diseases such as insulin resistance, type 1 and type 2 DM. There is no universal definition for cutoff value of vitamin D deficiency and it seems that it varies in different populations. OBJECTIVE: Most previous studies have used a start rise of PTH as a criteria to detect threshold of serum 25(OH)D, However, the aim of this study was to determine a cutoff point of serum 25(OH)D for vitamin D deficiency based on HOMA-IR. MATERIALS AND METHODS: Two hundred and ninety seven healthy children (aged 7-11 years) were enrolled. Serum 25(OH)D and PTH were measured and HOMA-IR was calculated. The ROC curve was utilized to obtain a cutoff of vitamin D deficiency based on HOMA-IR. RESULTS: 25(OH)D concentrations were inversely correlated with HOMA-IR levels (Spearman's r=-0.14, p=0.016). Serum 25(OH)D cutoff point was 11.6ng/mL (29nmol/L) in relation with HOMA-IR >2.1. By using this cutoff value, the prevalence of vitamin D deficiency was 43.4% in this study population of healthy children. CONCLUSION: We found that serum 25(OH)D levels are inversely associated with insulin resistance. These results suggest that in MetS patients it may benefit to determine cutoff value of 25(OH)D levels based on HOMA-IR. SN - 1878-0334 UR - https://www.unboundmedicine.com/medline/citation/24290086/Defining_a_cutoff_point_for_vitamin_D_deficiency_based_on_insulin_resistance_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1871-4021(13)00105-7 DB - PRIME DP - Unbound Medicine ER -