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Catechol-O-methyltransferase Val158Met polymorphism (rs4680) is associated with pain in multiple sclerosis.

Abstract

Alterations in the rs4680 Val158Met polymorphism are associated with the presence of pain. No study has investigated the role of Val158Met polymorphism in the susceptibility to exhibit pain in multiple sclerosis (MS). Our aim was to investigate the relationship between Val158Met polymorphism (rs4680) and the presence of pain in MS. One hundred eight (n = 108) patients (mean age: 44 ± 8 years) with a definitive diagnosis of MS and 108 matched controls participated. Fifty-eight patients (54%) had pain and 50 (46%) did not report pain. After amplifying Val158Met polymorphisms by polymerase chain reactions, rs4680 genotype frequencies and allele distributions were calculated. We classified individuals according to their Val158Met polymorphism: Val/Val, Val/Met, and Met/Met. The results showed that distribution of rs4680 Val158Met genotypes was not significantly different between individuals with MS in general and healthy people (χ2 = 2.212, P = .331). When we differentiate MS patients with pain and those without pain, the prevalence of Val158Met genotypes was significantly different (χ2 = 9,610, P = .046): Patients experiencing pain exhibited higher prevalence of Met/Met genotype than those without pain and healthy controls. Current results suggest that the Met allele of Val158Met polymorphism could be a potential risk factor for the development of pain in MS but not for the predisposition of MS itself.

PERSPECTIVE

This study suggests that the Val158Met polymorphism is associated with the presence of pain in MS, but it is not a risk factor for MS itself because the presence of the Met/Met genotype was more prevalent in those patients with pain. This study provides further evidence of potential genetic factors that predispose patients with MS to develop pain.

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  • Authors+Show Affiliations

    ,

    Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain; Esthesiology Laboratory, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain. Electronic address: cesar.fernandez@urjc.es.

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    MeSH

    Adult
    Alleles
    Catechol O-Methyltransferase
    Female
    Genetic Predisposition to Disease
    Genotype
    Humans
    Male
    Methionine
    Middle Aged
    Multiple Sclerosis
    Pain
    Pain Measurement
    Polymorphism, Single Nucleotide
    Risk Factors
    Single-Blind Method
    Valine

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    24290452

    Citation

    Fernández-de-las-Peñas, César, et al. "Catechol-O-methyltransferase Val158Met Polymorphism (rs4680) Is Associated With Pain in Multiple Sclerosis." The Journal of Pain : Official Journal of the American Pain Society, vol. 14, no. 12, 2013, pp. 1719-23.
    Fernández-de-las-Peñas C, Ambite-Quesada S, Ortíz-Gutiérrez R, et al. Catechol-O-methyltransferase Val158Met polymorphism (rs4680) is associated with pain in multiple sclerosis. J Pain. 2013;14(12):1719-23.
    Fernández-de-las-Peñas, C., Ambite-Quesada, S., Ortíz-Gutiérrez, R., Ortega-Santiago, R., Gil-Crujera, A., & Caminero, A. B. (2013). Catechol-O-methyltransferase Val158Met polymorphism (rs4680) is associated with pain in multiple sclerosis. The Journal of Pain : Official Journal of the American Pain Society, 14(12), pp. 1719-23. doi:10.1016/j.jpain.2013.09.007.
    Fernández-de-las-Peñas C, et al. Catechol-O-methyltransferase Val158Met Polymorphism (rs4680) Is Associated With Pain in Multiple Sclerosis. J Pain. 2013;14(12):1719-23. PubMed PMID: 24290452.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Catechol-O-methyltransferase Val158Met polymorphism (rs4680) is associated with pain in multiple sclerosis. AU - Fernández-de-las-Peñas,César, AU - Ambite-Quesada,Silvia, AU - Ortíz-Gutiérrez,Rosa, AU - Ortega-Santiago,Ricardo, AU - Gil-Crujera,Antonio, AU - Caminero,Ana B, Y1 - 2013/09/28/ PY - 2013/07/12/received PY - 2013/08/27/revised PY - 2013/09/03/accepted PY - 2013/12/3/entrez PY - 2013/12/3/pubmed PY - 2014/8/16/medline KW - Catechol-O-methyltransferase gene KW - multiple sclerosis KW - pain KW - polymorphism SP - 1719 EP - 23 JF - The journal of pain : official journal of the American Pain Society JO - J Pain VL - 14 IS - 12 N2 - UNLABELLED: Alterations in the rs4680 Val158Met polymorphism are associated with the presence of pain. No study has investigated the role of Val158Met polymorphism in the susceptibility to exhibit pain in multiple sclerosis (MS). Our aim was to investigate the relationship between Val158Met polymorphism (rs4680) and the presence of pain in MS. One hundred eight (n = 108) patients (mean age: 44 ± 8 years) with a definitive diagnosis of MS and 108 matched controls participated. Fifty-eight patients (54%) had pain and 50 (46%) did not report pain. After amplifying Val158Met polymorphisms by polymerase chain reactions, rs4680 genotype frequencies and allele distributions were calculated. We classified individuals according to their Val158Met polymorphism: Val/Val, Val/Met, and Met/Met. The results showed that distribution of rs4680 Val158Met genotypes was not significantly different between individuals with MS in general and healthy people (χ2 = 2.212, P = .331). When we differentiate MS patients with pain and those without pain, the prevalence of Val158Met genotypes was significantly different (χ2 = 9,610, P = .046): Patients experiencing pain exhibited higher prevalence of Met/Met genotype than those without pain and healthy controls. Current results suggest that the Met allele of Val158Met polymorphism could be a potential risk factor for the development of pain in MS but not for the predisposition of MS itself. PERSPECTIVE: This study suggests that the Val158Met polymorphism is associated with the presence of pain in MS, but it is not a risk factor for MS itself because the presence of the Met/Met genotype was more prevalent in those patients with pain. This study provides further evidence of potential genetic factors that predispose patients with MS to develop pain. SN - 1528-8447 UR - https://www.unboundmedicine.com/medline/citation/24290452/Catechol_O_methyltransferase_Val158Met_polymorphism__rs4680__is_associated_with_pain_in_multiple_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1526-5900(13)01241-8 DB - PRIME DP - Unbound Medicine ER -