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Higher insulin and glucagon-like peptide-1 (GLP-1) levels in healthy, young South Asians as compared to Caucasians during an oral glucose tolerance test.
Metabolism. 2014 Feb; 63(2):226-32.M

Abstract

OBJECTIVE

Higher insulin levels during an oral glucose test (OGTT) have been shown in South Asians. We aimed to investigate if this increased insulin response causes reactive hypoglycemia later on, and if an increased glucagon-like-peptide-1 (GLP-1) response, which could contribute to the hyperinsulinemia, is present in this ethnic group.

METHODS

A prolonged, 6-h, 75-g OGTT was performed in healthy, young Caucasian (n=10) and South Asian (n=8) men. The glucose, insulin and GLP-1 response was measured and indices of insulin sensitivity and beta-cell activity were calculated.

RESULTS

Age (Caucasians (CAU) 21.5±0.7 years vs South Asians (SA) 21.4±0.7 years (mean±SEM)) and body mass index (CAU 22.7±0.7 kg/m(2) vs SA 22.1±0.8 kg/m(2)) were comparable between the two groups. South Asian men were more insulin resistant, as indicated by a comparable glucose but significantly higher insulin response, and a significantly lower Matsuda index (CAU 8.7(8.6) vs SA 3.2(19.2), median(IQR)). South Asians showed a higher GLP-1 response, as reflected by a higher area under the curve for GLP-1 (CAU 851±99.8 mmol/l vs SA 1235±155.0 mmol/L). During the whole 6-h period, no reactive hypoglycemia was observed.

CONCLUSION

Healthy, young South Asian men have higher insulin levels during an OGTT as compared to Caucasians. This does not, however, lead to reactive hypoglycemia. The hyperinsulinemia is accompanied by increased levels of GLP-1. Whether this is an adaptive response to facilitate hyperinsulinemia to overcome insulin resistance or reflects a GLP-1 resistant state has yet to be elucidated.

Authors+Show Affiliations

Department of General Internal Medicine and Endocrinology & Metabolism, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: m.a.sleddering@lumc.nl.Department of General Internal Medicine and Endocrinology & Metabolism, Leiden University Medical Center, Leiden, The Netherlands.Department of General Internal Medicine and Endocrinology & Metabolism, Leiden University Medical Center, Leiden, The Netherlands.Department of General Internal Medicine and Endocrinology & Metabolism, Leiden University Medical Center, Leiden, The Netherlands.Department of General Internal Medicine and Endocrinology & Metabolism, Leiden University Medical Center, Leiden, The Netherlands.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24290838

Citation

Sleddering, Maria A., et al. "Higher Insulin and Glucagon-like Peptide-1 (GLP-1) Levels in Healthy, Young South Asians as Compared to Caucasians During an Oral Glucose Tolerance Test." Metabolism: Clinical and Experimental, vol. 63, no. 2, 2014, pp. 226-32.
Sleddering MA, Bakker LE, Janssen LG, et al. Higher insulin and glucagon-like peptide-1 (GLP-1) levels in healthy, young South Asians as compared to Caucasians during an oral glucose tolerance test. Metabolism. 2014;63(2):226-32.
Sleddering, M. A., Bakker, L. E., Janssen, L. G., Meinders, A. E., & Jazet, I. M. (2014). Higher insulin and glucagon-like peptide-1 (GLP-1) levels in healthy, young South Asians as compared to Caucasians during an oral glucose tolerance test. Metabolism: Clinical and Experimental, 63(2), 226-32. https://doi.org/10.1016/j.metabol.2013.10.008
Sleddering MA, et al. Higher Insulin and Glucagon-like Peptide-1 (GLP-1) Levels in Healthy, Young South Asians as Compared to Caucasians During an Oral Glucose Tolerance Test. Metabolism. 2014;63(2):226-32. PubMed PMID: 24290838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher insulin and glucagon-like peptide-1 (GLP-1) levels in healthy, young South Asians as compared to Caucasians during an oral glucose tolerance test. AU - Sleddering,Maria A, AU - Bakker,Leontine E H, AU - Janssen,Laura G M, AU - Meinders,A Edo, AU - Jazet,Ingrid M, Y1 - 2013/10/24/ PY - 2013/06/24/received PY - 2013/10/07/revised PY - 2013/10/18/accepted PY - 2013/12/3/entrez PY - 2013/12/3/pubmed PY - 2014/3/8/medline KW - AUC KW - BMI KW - CAU KW - Caucasian KW - DI(o) KW - DPP-IV KW - Dipeptidyl peptidase IV KW - GLP-1 KW - IGI KW - IQR KW - Insulin resistance KW - Insulin sensitivity KW - OGTT KW - SA KW - SEM KW - South Asian KW - T2DM KW - area under the curve KW - body mass index KW - glucagon-like-peptide-1 KW - insulinogenic index KW - interquartile range KW - oral disposition index KW - oral glucose tolerance test KW - standard error of the mean KW - type 2 diabetes mellitus. SP - 226 EP - 32 JF - Metabolism: clinical and experimental JO - Metabolism VL - 63 IS - 2 N2 - OBJECTIVE: Higher insulin levels during an oral glucose test (OGTT) have been shown in South Asians. We aimed to investigate if this increased insulin response causes reactive hypoglycemia later on, and if an increased glucagon-like-peptide-1 (GLP-1) response, which could contribute to the hyperinsulinemia, is present in this ethnic group. METHODS: A prolonged, 6-h, 75-g OGTT was performed in healthy, young Caucasian (n=10) and South Asian (n=8) men. The glucose, insulin and GLP-1 response was measured and indices of insulin sensitivity and beta-cell activity were calculated. RESULTS: Age (Caucasians (CAU) 21.5±0.7 years vs South Asians (SA) 21.4±0.7 years (mean±SEM)) and body mass index (CAU 22.7±0.7 kg/m(2) vs SA 22.1±0.8 kg/m(2)) were comparable between the two groups. South Asian men were more insulin resistant, as indicated by a comparable glucose but significantly higher insulin response, and a significantly lower Matsuda index (CAU 8.7(8.6) vs SA 3.2(19.2), median(IQR)). South Asians showed a higher GLP-1 response, as reflected by a higher area under the curve for GLP-1 (CAU 851±99.8 mmol/l vs SA 1235±155.0 mmol/L). During the whole 6-h period, no reactive hypoglycemia was observed. CONCLUSION: Healthy, young South Asian men have higher insulin levels during an OGTT as compared to Caucasians. This does not, however, lead to reactive hypoglycemia. The hyperinsulinemia is accompanied by increased levels of GLP-1. Whether this is an adaptive response to facilitate hyperinsulinemia to overcome insulin resistance or reflects a GLP-1 resistant state has yet to be elucidated. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/24290838/Higher_insulin_and_glucagon_like_peptide_1__GLP_1__levels_in_healthy_young_South_Asians_as_compared_to_Caucasians_during_an_oral_glucose_tolerance_test_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(13)00340-5 DB - PRIME DP - Unbound Medicine ER -