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Influenza vaccination and risk of hospitalization among adults with laboratory confirmed influenza illness.
Vaccine. 2014 Jan 16; 32(4):453-7.V

Abstract

BACKGROUND

Influenza vaccine is moderately effective for preventing influenza illness. It is not known if vaccination reduces the risk of subsequent hospital admission among patients with vaccine failure and laboratory confirmed influenza illness.

METHODS

Patients in a community cohort presenting with acute respiratory illness were prospectively enrolled and tested for influenza during 8 seasons to estimate seasonal vaccine effectiveness. Hospital admissions within 14 days after illness onset were identified for all participants aged ≥20 years with laboratory confirmed influenza. The association between vaccination and hospital admission was examined in a propensity score adjusted logistic regression model. The model was validated by examining the association between vaccination and hospital admission in participants without influenza.

RESULTS

Influenza was identified in 1393 (28%) of 4996 participants. Sixty-two (6%) of 1020 with influenza A and 17 (5%) of 369 with influenza B were hospitalized. Vaccination was not associated with a reduced risk of hospital admission among all participants with influenza [adjusted odds ratio (aOR)=1.08; 95% CI: 0.62, 1.88]; or among those with influenza A (aOR=1.35; 95% CI: 0.71, 2.57) or influenza B (aOR=0.67; 95% CI: 0.21, 2.15). Influenza vaccination was not associated with hospitalization after non-influenza respiratory illness (aOR=1.14; 95% CI: 0.84, 1.54).

CONCLUSIONS

Influenza vaccination did not reduce the risk of subsequent hospital admission among patients with vaccine failure. These findings do not support the hypothesis that vaccination mitigates influenza illness severity.

Authors+Show Affiliations

Marshfield Clinic Research Foundation, Marshfield, WI, USA. Electronic address: mclean.huong@marshfieldclinic.org.Marshfield Clinic Research Foundation, Marshfield, WI, USA.Marshfield Clinic Research Foundation, Marshfield, WI, USA.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

24291201

Citation

McLean, Huong Q., et al. "Influenza Vaccination and Risk of Hospitalization Among Adults With Laboratory Confirmed Influenza Illness." Vaccine, vol. 32, no. 4, 2014, pp. 453-7.
McLean HQ, Meece JK, Belongia EA. Influenza vaccination and risk of hospitalization among adults with laboratory confirmed influenza illness. Vaccine. 2014;32(4):453-7.
McLean, H. Q., Meece, J. K., & Belongia, E. A. (2014). Influenza vaccination and risk of hospitalization among adults with laboratory confirmed influenza illness. Vaccine, 32(4), 453-7. https://doi.org/10.1016/j.vaccine.2013.11.060
McLean HQ, Meece JK, Belongia EA. Influenza Vaccination and Risk of Hospitalization Among Adults With Laboratory Confirmed Influenza Illness. Vaccine. 2014 Jan 16;32(4):453-7. PubMed PMID: 24291201.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influenza vaccination and risk of hospitalization among adults with laboratory confirmed influenza illness. AU - McLean,Huong Q, AU - Meece,Jennifer K, AU - Belongia,Edward A, Y1 - 2013/11/26/ PY - 2013/09/13/received PY - 2013/11/12/revised PY - 2013/11/15/accepted PY - 2013/12/3/entrez PY - 2013/12/3/pubmed PY - 2014/8/6/medline KW - Effectiveness KW - Hospitalization KW - Influenza vaccine KW - Severity SP - 453 EP - 7 JF - Vaccine JO - Vaccine VL - 32 IS - 4 N2 - BACKGROUND: Influenza vaccine is moderately effective for preventing influenza illness. It is not known if vaccination reduces the risk of subsequent hospital admission among patients with vaccine failure and laboratory confirmed influenza illness. METHODS: Patients in a community cohort presenting with acute respiratory illness were prospectively enrolled and tested for influenza during 8 seasons to estimate seasonal vaccine effectiveness. Hospital admissions within 14 days after illness onset were identified for all participants aged ≥20 years with laboratory confirmed influenza. The association between vaccination and hospital admission was examined in a propensity score adjusted logistic regression model. The model was validated by examining the association between vaccination and hospital admission in participants without influenza. RESULTS: Influenza was identified in 1393 (28%) of 4996 participants. Sixty-two (6%) of 1020 with influenza A and 17 (5%) of 369 with influenza B were hospitalized. Vaccination was not associated with a reduced risk of hospital admission among all participants with influenza [adjusted odds ratio (aOR)=1.08; 95% CI: 0.62, 1.88]; or among those with influenza A (aOR=1.35; 95% CI: 0.71, 2.57) or influenza B (aOR=0.67; 95% CI: 0.21, 2.15). Influenza vaccination was not associated with hospitalization after non-influenza respiratory illness (aOR=1.14; 95% CI: 0.84, 1.54). CONCLUSIONS: Influenza vaccination did not reduce the risk of subsequent hospital admission among patients with vaccine failure. These findings do not support the hypothesis that vaccination mitigates influenza illness severity. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/24291201/Influenza_vaccination_and_risk_of_hospitalization_among_adults_with_laboratory_confirmed_influenza_illness_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(13)01594-6 DB - PRIME DP - Unbound Medicine ER -