Citation
Wendler, Etieli, et al. "The Roles of the Nucleus Accumbens Core, Dorsomedial Striatum, and Dorsolateral Striatum in Learning: Performance and Extinction of Pavlovian Fear-conditioned Responses and Instrumental Avoidance Responses." Neurobiology of Learning and Memory, vol. 109, 2014, pp. 27-36.
Wendler E, Gaspar JC, Ferreira TL, et al. The roles of the nucleus accumbens core, dorsomedial striatum, and dorsolateral striatum in learning: performance and extinction of Pavlovian fear-conditioned responses and instrumental avoidance responses. Neurobiol Learn Mem. 2014;109:27-36.
Wendler, E., Gaspar, J. C., Ferreira, T. L., Barbiero, J. K., Andreatini, R., Vital, M. A., Blaha, C. D., Winn, P., & Da Cunha, C. (2014). The roles of the nucleus accumbens core, dorsomedial striatum, and dorsolateral striatum in learning: performance and extinction of Pavlovian fear-conditioned responses and instrumental avoidance responses. Neurobiology of Learning and Memory, 109, 27-36. https://doi.org/10.1016/j.nlm.2013.11.009
Wendler E, et al. The Roles of the Nucleus Accumbens Core, Dorsomedial Striatum, and Dorsolateral Striatum in Learning: Performance and Extinction of Pavlovian Fear-conditioned Responses and Instrumental Avoidance Responses. Neurobiol Learn Mem. 2014;109:27-36. PubMed PMID: 24291572.
TY - JOUR
T1 - The roles of the nucleus accumbens core, dorsomedial striatum, and dorsolateral striatum in learning: performance and extinction of Pavlovian fear-conditioned responses and instrumental avoidance responses.
AU - Wendler,Etieli,
AU - Gaspar,Jessica C C,
AU - Ferreira,Tatiana L,
AU - Barbiero,Janaína K,
AU - Andreatini,Roberto,
AU - Vital,Maria A B F,
AU - Blaha,Charles D,
AU - Winn,Philip,
AU - Da Cunha,Claudio,
Y1 - 2013/11/26/
PY - 2013/04/10/received
PY - 2013/10/16/revised
PY - 2013/11/18/accepted
PY - 2013/12/3/entrez
PY - 2013/12/3/pubmed
PY - 2014/10/31/medline
KW - Caudate–putamen
KW - Conditioned avoidance responses
KW - Neostriatum
KW - Pavlovian fear conditioning
KW - Procedural memory
KW - Ventral striatum
SP - 27
EP - 36
JF - Neurobiology of learning and memory
JO - Neurobiol Learn Mem
VL - 109
N2 - This study examined the effects of bilateral excitotoxic lesions of the nucleus accumbens core (NAc-co), dorsomedial striatum (DMS) or dorsolateral striatum (DLS) of rats on the learning and extinction of Pavlovian and instrumental components of conditioned avoidance responses (CARs). None of the lesions caused sensorimotor deficits that could affect locomotion. Lesions of the NAc-co, but not DMS or DLS, decreased unconditioned and conditioned freezing. The NAc-co and DLS lesioned rats learned the 2-way active avoidance task more slowly. These results suggest: (i) CARs depend on both Pavlovian and instrumental learning; (ii) learning the Pavlovian component of CARs depends on the NAc-co; learning the instrumental component of CARs depends on the DLS, NAc and DMS; (iii) although the NAc-co is also needed for learning the instrumental component, it is not clear whether it plays a role in learning the instrumental component per se or if it simply allows learning of the Pavlovian component which is a pre-condition for learning the instrumental component; (iv) we did not find evidence that the DMS and DLS play the same roles in habit and goal-directed aspects of the instrumental component of CARs as observed in appetitive motivated instrumental responding.
SN - 1095-9564
UR - https://www.unboundmedicine.com/medline/citation/24291572/The_roles_of_the_nucleus_accumbens_core_dorsomedial_striatum_and_dorsolateral_striatum_in_learning:_performance_and_extinction_of_Pavlovian_fear_conditioned_responses_and_instrumental_avoidance_responses_
DB - PRIME
DP - Unbound Medicine
ER -
