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Quantum dots sensitized titanium dioxide decorated reduced graphene oxide for visible light excited photoelectrochemical biosensing at a low potential.
Biosens Bioelectron. 2014 Apr 15; 54:331-8.BB

Abstract

A low potential and competitive photoelectrochemical biosensing platform was developed using quantum dots sensitized titanium dioxide decorated reduced graphene oxide (TiO2-RGO) nanocomposites. The nanocomposites were prepared through electrostatic interaction between mercaptoacetic acid wrapped CdSe quantum dots with negative charge and TiO2-RGO hybrids with positive charge obtained via ultrasonic and acid treatments. Electron microscopes and spectroscopes were used to characterize the functionalized nanocomposites films of CdSe/TiO2-RGO, and the fabrication process of the photoelectrochemical biosensor. Based on the high photovoltaic conversion efficiency of CdSe/TiO2-RGO nanocomposites films, after introducing biological recognition and competitive immunoreaction, a low potential and competitive photoelectrochemical biosensor for carcinoembryonic antigen (CEA) detection was fabricated. The synergic effect of horseradish peroxide and benzo-4-chlorohexadienone decreased the background signal, leading to signal amplification. Under the light irradiation of 430 nm and the applied potential of 0 V, the biosensor detected CEA with a linear range from 0.003 to 100 ng mL(-1) and the detection limit was estimated to be 1.38 pg mL(-1) at a S/N of 3. It was satisfactory for clinical sample detection. The proposed competitive and low potential photoelectrochemical biosensor under irradiation of visible light exhibited good performance, which has a promising prospect in clinical diagnose.

Authors+Show Affiliations

Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China.Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China.Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China.Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China.Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China. Electronic address: daizhihuii@njnu.edu.cn.

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24291752

Citation

Zeng, Xianxiang, et al. "Quantum Dots Sensitized Titanium Dioxide Decorated Reduced Graphene Oxide for Visible Light Excited Photoelectrochemical Biosensing at a Low Potential." Biosensors & Bioelectronics, vol. 54, 2014, pp. 331-8.
Zeng X, Bao J, Han M, et al. Quantum dots sensitized titanium dioxide decorated reduced graphene oxide for visible light excited photoelectrochemical biosensing at a low potential. Biosens Bioelectron. 2014;54:331-8.
Zeng, X., Bao, J., Han, M., Tu, W., & Dai, Z. (2014). Quantum dots sensitized titanium dioxide decorated reduced graphene oxide for visible light excited photoelectrochemical biosensing at a low potential. Biosensors & Bioelectronics, 54, 331-8. https://doi.org/10.1016/j.bios.2013.10.057
Zeng X, et al. Quantum Dots Sensitized Titanium Dioxide Decorated Reduced Graphene Oxide for Visible Light Excited Photoelectrochemical Biosensing at a Low Potential. Biosens Bioelectron. 2014 Apr 15;54:331-8. PubMed PMID: 24291752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantum dots sensitized titanium dioxide decorated reduced graphene oxide for visible light excited photoelectrochemical biosensing at a low potential. AU - Zeng,Xianxiang, AU - Bao,Jianchun, AU - Han,Min, AU - Tu,Wenwen, AU - Dai,Zhihui, Y1 - 2013/11/04/ PY - 2013/09/10/received PY - 2013/10/26/revised PY - 2013/10/28/accepted PY - 2013/12/3/entrez PY - 2013/12/3/pubmed PY - 2014/9/17/medline KW - Biosensing KW - Photoelectrochemistry KW - Quantum dots KW - Reduced graphene oxide KW - Signal amplification SP - 331 EP - 8 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 54 N2 - A low potential and competitive photoelectrochemical biosensing platform was developed using quantum dots sensitized titanium dioxide decorated reduced graphene oxide (TiO2-RGO) nanocomposites. The nanocomposites were prepared through electrostatic interaction between mercaptoacetic acid wrapped CdSe quantum dots with negative charge and TiO2-RGO hybrids with positive charge obtained via ultrasonic and acid treatments. Electron microscopes and spectroscopes were used to characterize the functionalized nanocomposites films of CdSe/TiO2-RGO, and the fabrication process of the photoelectrochemical biosensor. Based on the high photovoltaic conversion efficiency of CdSe/TiO2-RGO nanocomposites films, after introducing biological recognition and competitive immunoreaction, a low potential and competitive photoelectrochemical biosensor for carcinoembryonic antigen (CEA) detection was fabricated. The synergic effect of horseradish peroxide and benzo-4-chlorohexadienone decreased the background signal, leading to signal amplification. Under the light irradiation of 430 nm and the applied potential of 0 V, the biosensor detected CEA with a linear range from 0.003 to 100 ng mL(-1) and the detection limit was estimated to be 1.38 pg mL(-1) at a S/N of 3. It was satisfactory for clinical sample detection. The proposed competitive and low potential photoelectrochemical biosensor under irradiation of visible light exhibited good performance, which has a promising prospect in clinical diagnose. SN - 1873-4235 UR - https://www.unboundmedicine.com/medline/citation/24291752/Quantum_dots_sensitized_titanium_dioxide_decorated_reduced_graphene_oxide_for_visible_light_excited_photoelectrochemical_biosensing_at_a_low_potential_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(13)00759-8 DB - PRIME DP - Unbound Medicine ER -