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Hypocholesterolaemic and antioxidant effects of yerba mate (Ilex paraguariensis) in high-cholesterol fed rats.
Fitoterapia. 2014 Jan; 92:219-29.F

Abstract

OBJECTIVE

To study the effect of mate (Ilex paraguariensis) on serum lipids and antioxidant status in normocholesterolaemic and hypercholesterolaemic rats.

METHODS

Triglycerides (TG), total, LDL- and HDL-cholesterol levels, total antioxidant capacity (FRAP and ABTS assays), malondialdehyde (MDA) and protein carbonyls were analysed in serum, and MDA, glutathione and antioxidant enzyme activity in livers of rats drinking water or mate fed normal or cholesterol-cholic supplemented diets.

RESULTS

ABTS, glutathione and antioxidant enzymes were not affected by any treatment. In normocholesterolaemic animals, mate had no effect on serum lipids or antioxidant status, yet it increased serum carbonyls and liver MDA concentrations. In hypercholesterolaemic rats, mate consumption had no effect on HDL-cholesterol or protein carbonyls, yet it showed a marked hypolipidaemic action, decreasing TG, total and LDL-cholesterol, and serum MDA levels that had been increased after consuming the high-cholesterol diet.

CONCLUSION

Potential beneficial effect of mate on markers of cardiovascular risk seems to be restricted to hyperlipaemic animals.

Authors+Show Affiliations

Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), C/José Antonio Novais 10, 28040 Madrid, Spain.Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), C/José Antonio Novais 10, 28040 Madrid, Spain.Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), C/José Antonio Novais 10, 28040 Madrid, Spain. Electronic address: beasarria@ictan.csic.es.Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), C/José Antonio Novais 10, 28040 Madrid, Spain.Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), C/José Antonio Novais 10, 28040 Madrid, Spain.Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), C/José Antonio Novais 10, 28040 Madrid, Spain.Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), C/José Antonio Novais 10, 28040 Madrid, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24291756

Citation

Bravo, Laura, et al. "Hypocholesterolaemic and Antioxidant Effects of Yerba Mate (Ilex Paraguariensis) in High-cholesterol Fed Rats." Fitoterapia, vol. 92, 2014, pp. 219-29.
Bravo L, Mateos R, Sarriá B, et al. Hypocholesterolaemic and antioxidant effects of yerba mate (Ilex paraguariensis) in high-cholesterol fed rats. Fitoterapia. 2014;92:219-29.
Bravo, L., Mateos, R., Sarriá, B., Baeza, G., Lecumberri, E., Ramos, S., & Goya, L. (2014). Hypocholesterolaemic and antioxidant effects of yerba mate (Ilex paraguariensis) in high-cholesterol fed rats. Fitoterapia, 92, 219-29. https://doi.org/10.1016/j.fitote.2013.11.007
Bravo L, et al. Hypocholesterolaemic and Antioxidant Effects of Yerba Mate (Ilex Paraguariensis) in High-cholesterol Fed Rats. Fitoterapia. 2014;92:219-29. PubMed PMID: 24291756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypocholesterolaemic and antioxidant effects of yerba mate (Ilex paraguariensis) in high-cholesterol fed rats. AU - Bravo,Laura, AU - Mateos,Raquel, AU - Sarriá,Beatriz, AU - Baeza,Gema, AU - Lecumberri,Elena, AU - Ramos,Sonia, AU - Goya,Luis, Y1 - 2013/11/27/ PY - 2013/07/10/received PY - 2013/11/13/revised PY - 2013/11/20/accepted PY - 2013/12/3/entrez PY - 2013/12/3/pubmed PY - 2014/9/13/medline KW - 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt KW - ABTS KW - Antioxidant polyphenols KW - Biomarkers of oxidative stress KW - CAT KW - CVD KW - Cardiovascular risk KW - FRAP KW - GPx KW - GR KW - GSH KW - HDL-C KW - LDL-C KW - Lipid profile KW - MDA KW - Mate KW - SOD KW - T-C KW - TG KW - cardiovascular disease KW - catalase KW - ferric reducing antioxidant power method KW - glutathione peroxidase KW - glutathione reductase KW - high density lipoprotein-cholesterol KW - low density lipoprotein cholesterol KW - malondialdehyde KW - reduced glutathione KW - superoxide dismutase KW - total cholesterol KW - triglycerides SP - 219 EP - 29 JF - Fitoterapia JO - Fitoterapia VL - 92 N2 - OBJECTIVE: To study the effect of mate (Ilex paraguariensis) on serum lipids and antioxidant status in normocholesterolaemic and hypercholesterolaemic rats. METHODS: Triglycerides (TG), total, LDL- and HDL-cholesterol levels, total antioxidant capacity (FRAP and ABTS assays), malondialdehyde (MDA) and protein carbonyls were analysed in serum, and MDA, glutathione and antioxidant enzyme activity in livers of rats drinking water or mate fed normal or cholesterol-cholic supplemented diets. RESULTS: ABTS, glutathione and antioxidant enzymes were not affected by any treatment. In normocholesterolaemic animals, mate had no effect on serum lipids or antioxidant status, yet it increased serum carbonyls and liver MDA concentrations. In hypercholesterolaemic rats, mate consumption had no effect on HDL-cholesterol or protein carbonyls, yet it showed a marked hypolipidaemic action, decreasing TG, total and LDL-cholesterol, and serum MDA levels that had been increased after consuming the high-cholesterol diet. CONCLUSION: Potential beneficial effect of mate on markers of cardiovascular risk seems to be restricted to hyperlipaemic animals. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/24291756/Hypocholesterolaemic_and_antioxidant_effects_of_yerba_mate__Ilex_paraguariensis__in_high_cholesterol_fed_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(13)00302-X DB - PRIME DP - Unbound Medicine ER -