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[Cognitive function and blood pressure regulation in Lewy body diseases].
Rinsho Shinkeigaku. 2013; 53(11):1386-8.RS

Abstract

It is well known that autonomic failure is severer in patients with dementia with Lewy bodies (DLB) compared with patients with Parkinson's disease (PD). According to the Braak's hypothesis, Lewy bodies first appear in the olfactory bulb or peripheral autonomic nervous system. Lewy bodies in the peripheral autonomic nervous system ascend to dorsal motor nuclei of vagus nerve, while those in the olfactory bulb expand to the limbic system. Lewy bodies later attain the substantia nigra. However, it seems that Braak staging can not explain difference in severity of autonomic failure between DLB and PD. As a possibility, in DLB patients with significant autonomic failure, Lewy bodies may have been localized to the peripheral autonomic nervous system in a long time before onset of dementia or parkinsonism, and propagation of Lewy bodies into the central nervous system may be initiated by apparition of certain promotion factor, such as ageing and amyloid-β.

Authors+Show Affiliations

Department of Neurology, Chiba University School of Medicine.

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

24291999

Citation

Asahina, Masato. "[Cognitive Function and Blood Pressure Regulation in Lewy Body Diseases]." Rinsho Shinkeigaku = Clinical Neurology, vol. 53, no. 11, 2013, pp. 1386-8.
Asahina M. [Cognitive function and blood pressure regulation in Lewy body diseases]. Rinsho Shinkeigaku. 2013;53(11):1386-8.
Asahina, M. (2013). [Cognitive function and blood pressure regulation in Lewy body diseases]. Rinsho Shinkeigaku = Clinical Neurology, 53(11), 1386-8.
Asahina M. [Cognitive Function and Blood Pressure Regulation in Lewy Body Diseases]. Rinsho Shinkeigaku. 2013;53(11):1386-8. PubMed PMID: 24291999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Cognitive function and blood pressure regulation in Lewy body diseases]. A1 - Asahina,Masato, PY - 2013/12/3/entrez PY - 2013/12/3/pubmed PY - 2014/9/23/medline SP - 1386 EP - 8 JF - Rinsho shinkeigaku = Clinical neurology JO - Rinsho Shinkeigaku VL - 53 IS - 11 N2 - It is well known that autonomic failure is severer in patients with dementia with Lewy bodies (DLB) compared with patients with Parkinson's disease (PD). According to the Braak's hypothesis, Lewy bodies first appear in the olfactory bulb or peripheral autonomic nervous system. Lewy bodies in the peripheral autonomic nervous system ascend to dorsal motor nuclei of vagus nerve, while those in the olfactory bulb expand to the limbic system. Lewy bodies later attain the substantia nigra. However, it seems that Braak staging can not explain difference in severity of autonomic failure between DLB and PD. As a possibility, in DLB patients with significant autonomic failure, Lewy bodies may have been localized to the peripheral autonomic nervous system in a long time before onset of dementia or parkinsonism, and propagation of Lewy bodies into the central nervous system may be initiated by apparition of certain promotion factor, such as ageing and amyloid-β. SN - 1882-0654 UR - https://www.unboundmedicine.com/medline/citation/24291999/[Cognitive_function_and_blood_pressure_regulation_in_Lewy_body_diseases]_ L2 - http://joi.jlc.jst.go.jp/DN/JST.JSTAGE/clinicalneurol/53.1386?from=PubMed DB - PRIME DP - Unbound Medicine ER -