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Thotneosides A, B and C: potent antioxidants from nepalese crude drug, leaves of Aconogonon molle.
Chem Pharm Bull (Tokyo). 2014; 62(2):191-5.CP

Abstract

Three new glycosides: thotneoside A (quercetin 3-O-(6″-O-phenylacetyl)-β-D-galactopyranoside) (1), thotneoside B (quercetin 3-O-(6″-O-phenylacetyl)-β-D-glucopyranoside) (2) and thotneoside C (3-methyl-2-butenoic acid 1-O-β-D-glucopyranoside) (3), together with nine known compounds; quercetin (4), quercetin 3-O-β-D-galactopyranoside (5), quercetin 3-O-(6″-O-galloyl)-β-D-galactopyranoside (6), quercetin 3-O-β-D-galacturonopyranoside (7), quercetin 3-O-β-D-glucuronopyranoside (8), quercetin 3-O-α-L-rhamnopyranoside (9), rutin (10), quercetin 3-O-α-L-arabinopyranoside (11) and 2,4,6-trihydroxyacetophenone 2-O-β-D-glucopyranoside (12) have been isolated from the shade dried leaves of Aconogonon molle, commonly known as "Thotne″ in Nepal. The structures were elucidated on the basis of chemical and spectroscopic methods. All of these compounds were isolated for the first time from A. molle and their in vitro antioxidant activity was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay. Quercetin (4) and its glycosides (1-2, 5-11) showed potent free radical scavenging activity.

Authors+Show Affiliations

Joshi KR
Graduate School of Pharmaceutical Sciences, Kumamoto University.
Devkota HP
No affiliation info available
Watanabe T
No affiliation info available
Yahara S
No affiliation info available

MeSH

AntioxidantsBiphenyl CompoundsFree RadicalsGlycosidesPicratesPlant LeavesPolygonaceaeQuercetin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24292866

Citation

Joshi, Khem Raj, et al. "Thotneosides A, B and C: Potent Antioxidants From Nepalese Crude Drug, Leaves of Aconogonon Molle." Chemical & Pharmaceutical Bulletin, vol. 62, no. 2, 2014, pp. 191-5.
Joshi KR, Devkota HP, Watanabe T, et al. Thotneosides A, B and C: potent antioxidants from nepalese crude drug, leaves of Aconogonon molle. Chem Pharm Bull (Tokyo). 2014;62(2):191-5.
Joshi, K. R., Devkota, H. P., Watanabe, T., & Yahara, S. (2014). Thotneosides A, B and C: potent antioxidants from nepalese crude drug, leaves of Aconogonon molle. Chemical & Pharmaceutical Bulletin, 62(2), 191-5.
Joshi KR, et al. Thotneosides A, B and C: Potent Antioxidants From Nepalese Crude Drug, Leaves of Aconogonon Molle. Chem Pharm Bull (Tokyo). 2014;62(2):191-5. PubMed PMID: 24292866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thotneosides A, B and C: potent antioxidants from nepalese crude drug, leaves of Aconogonon molle. AU - Joshi,Khem Raj, AU - Devkota,Hari Prasad, AU - Watanabe,Takashi, AU - Yahara,Shoji, Y1 - 2013/11/30/ PY - 2013/12/3/entrez PY - 2013/12/3/pubmed PY - 2014/9/30/medline SP - 191 EP - 5 JF - Chemical & pharmaceutical bulletin JO - Chem Pharm Bull (Tokyo) VL - 62 IS - 2 N2 - Three new glycosides: thotneoside A (quercetin 3-O-(6″-O-phenylacetyl)-β-D-galactopyranoside) (1), thotneoside B (quercetin 3-O-(6″-O-phenylacetyl)-β-D-glucopyranoside) (2) and thotneoside C (3-methyl-2-butenoic acid 1-O-β-D-glucopyranoside) (3), together with nine known compounds; quercetin (4), quercetin 3-O-β-D-galactopyranoside (5), quercetin 3-O-(6″-O-galloyl)-β-D-galactopyranoside (6), quercetin 3-O-β-D-galacturonopyranoside (7), quercetin 3-O-β-D-glucuronopyranoside (8), quercetin 3-O-α-L-rhamnopyranoside (9), rutin (10), quercetin 3-O-α-L-arabinopyranoside (11) and 2,4,6-trihydroxyacetophenone 2-O-β-D-glucopyranoside (12) have been isolated from the shade dried leaves of Aconogonon molle, commonly known as "Thotne″ in Nepal. The structures were elucidated on the basis of chemical and spectroscopic methods. All of these compounds were isolated for the first time from A. molle and their in vitro antioxidant activity was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay. Quercetin (4) and its glycosides (1-2, 5-11) showed potent free radical scavenging activity. SN - 1347-5223 UR - https://www.unboundmedicine.com/medline/citation/24292866/Thotneosides_A_B_and_C:_potent_antioxidants_from_nepalese_crude_drug_leaves_of_Aconogonon_molle_ DB - PRIME DP - Unbound Medicine ER -