Tags

Type your tag names separated by a space and hit enter

The impact of iodinated contrast agent administered during preoperative computed tomography scan on body iodine pool in patients with differentiated thyroid cancer preparing for radioactive iodine treatment.
Thyroid. 2014 May; 24(5):872-7.T

Abstract

BACKGROUND

Iodine in iodinated contrast agents (ICAs) interferes with radioactive iodine treatment (RAIT) and diagnostic scans in patients with differentiated thyroid carcinoma (DTC) because it can compete with ¹³¹I. Published guidelines recommend delaying RAIT for three to four months in patients who have been exposed to ICA. Spot urinary iodine concentration is a useful marker to reflect the body iodine pool. We investigated the impact of ICAs administered at preoperative computed tomography (CT) scan on the body iodine pool to determine the proper time interval between preoperative CT and RAIT in DTC patients.

METHODS

We performed a retrospective review of 1023 patients with DTC who underwent a preoperative CT scan with ICA, total thyroidectomy, and one week of low-iodine diet in preparation for RAIT. Urine iodine excretion (UIE) was measured in spot urine by inductively coupled plasma mass spectrometry and reported both in simple concentration (μg/L) and divided by gram creatinine (μg/gCr). Patients were divided into five groups by time interval in days between preoperative CT scan and spot urine iodine measurement (A, 31-60 [n=29]; B, 61-90 [n=155]; C, 91-120 [n=546]; D, 121-150 [n=226]; E, 151-180 [n=67]).

RESULTS

The median (interquartile range) of UIE (μg/gCr) in each group was 44.4 (27.7-73.2) in group A, 33.3 (22.8-64.7) in group B, 32.7 (20.8-63.0) in group C, 32.0 (20.6-67.0) in group D, and 30.4 (19.6-70.8) in group E. There was no significant difference between group A and the remaining groups (p>0.05) Also, the proportion of patients who achieved the appropriate UIE for RAIT according to our hospital's cutoff (≤66.2 μg/gCr) was not different between groups (A, 72.4%; B, 76.1%; C, 77.5%; D, 74.8%; E, 74.6%) (p=0.78).

CONCLUSION

This study shows that a UIE of one month after preoperative CT scan with ICA was not higher than that of six months after CT scan in patients who underwent total thyroidectomy for DTC. Thus, current guidelines that recommend delay of RAIT for three to four months after CT scan with ICA should be revisited and future studies to clarify the appropriate time interval between CT scan with ICA and RAIT are warranted.

Authors+Show Affiliations

1 Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24295076

Citation

Sohn, Seo Young, et al. "The Impact of Iodinated Contrast Agent Administered During Preoperative Computed Tomography Scan On Body Iodine Pool in Patients With Differentiated Thyroid Cancer Preparing for Radioactive Iodine Treatment." Thyroid : Official Journal of the American Thyroid Association, vol. 24, no. 5, 2014, pp. 872-7.
Sohn SY, Choi JH, Kim NK, et al. The impact of iodinated contrast agent administered during preoperative computed tomography scan on body iodine pool in patients with differentiated thyroid cancer preparing for radioactive iodine treatment. Thyroid. 2014;24(5):872-7.
Sohn, S. Y., Choi, J. H., Kim, N. K., Joung, J. Y., Cho, Y. Y., Park, S. M., Kim, T. H., Jin, S. M., Bae, J. C., Lee, S. Y., Chung, J. H., & Kim, S. W. (2014). The impact of iodinated contrast agent administered during preoperative computed tomography scan on body iodine pool in patients with differentiated thyroid cancer preparing for radioactive iodine treatment. Thyroid : Official Journal of the American Thyroid Association, 24(5), 872-7. https://doi.org/10.1089/thy.2013.0238
Sohn SY, et al. The Impact of Iodinated Contrast Agent Administered During Preoperative Computed Tomography Scan On Body Iodine Pool in Patients With Differentiated Thyroid Cancer Preparing for Radioactive Iodine Treatment. Thyroid. 2014;24(5):872-7. PubMed PMID: 24295076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of iodinated contrast agent administered during preoperative computed tomography scan on body iodine pool in patients with differentiated thyroid cancer preparing for radioactive iodine treatment. AU - Sohn,Seo Young, AU - Choi,Ji Hun, AU - Kim,Na Kyung, AU - Joung,Ji Young, AU - Cho,Yoon Young, AU - Park,Sun Mi, AU - Kim,Tae Hun, AU - Jin,Sang Man, AU - Bae,Ji Cheol, AU - Lee,Soo Youn, AU - Chung,Jae Hoon, AU - Kim,Sun Wook, Y1 - 2014/03/06/ PY - 2013/12/4/entrez PY - 2013/12/4/pubmed PY - 2015/1/13/medline SP - 872 EP - 7 JF - Thyroid : official journal of the American Thyroid Association JO - Thyroid VL - 24 IS - 5 N2 - BACKGROUND: Iodine in iodinated contrast agents (ICAs) interferes with radioactive iodine treatment (RAIT) and diagnostic scans in patients with differentiated thyroid carcinoma (DTC) because it can compete with ¹³¹I. Published guidelines recommend delaying RAIT for three to four months in patients who have been exposed to ICA. Spot urinary iodine concentration is a useful marker to reflect the body iodine pool. We investigated the impact of ICAs administered at preoperative computed tomography (CT) scan on the body iodine pool to determine the proper time interval between preoperative CT and RAIT in DTC patients. METHODS: We performed a retrospective review of 1023 patients with DTC who underwent a preoperative CT scan with ICA, total thyroidectomy, and one week of low-iodine diet in preparation for RAIT. Urine iodine excretion (UIE) was measured in spot urine by inductively coupled plasma mass spectrometry and reported both in simple concentration (μg/L) and divided by gram creatinine (μg/gCr). Patients were divided into five groups by time interval in days between preoperative CT scan and spot urine iodine measurement (A, 31-60 [n=29]; B, 61-90 [n=155]; C, 91-120 [n=546]; D, 121-150 [n=226]; E, 151-180 [n=67]). RESULTS: The median (interquartile range) of UIE (μg/gCr) in each group was 44.4 (27.7-73.2) in group A, 33.3 (22.8-64.7) in group B, 32.7 (20.8-63.0) in group C, 32.0 (20.6-67.0) in group D, and 30.4 (19.6-70.8) in group E. There was no significant difference between group A and the remaining groups (p>0.05) Also, the proportion of patients who achieved the appropriate UIE for RAIT according to our hospital's cutoff (≤66.2 μg/gCr) was not different between groups (A, 72.4%; B, 76.1%; C, 77.5%; D, 74.8%; E, 74.6%) (p=0.78). CONCLUSION: This study shows that a UIE of one month after preoperative CT scan with ICA was not higher than that of six months after CT scan in patients who underwent total thyroidectomy for DTC. Thus, current guidelines that recommend delay of RAIT for three to four months after CT scan with ICA should be revisited and future studies to clarify the appropriate time interval between CT scan with ICA and RAIT are warranted. SN - 1557-9077 UR - https://www.unboundmedicine.com/medline/citation/24295076/The_impact_of_iodinated_contrast_agent_administered_during_preoperative_computed_tomography_scan_on_body_iodine_pool_in_patients_with_differentiated_thyroid_cancer_preparing_for_radioactive_iodine_treatment_ L2 - https://www.liebertpub.com/doi/full/10.1089/thy.2013.0238?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -