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A Meta-analysis of the relation between chemokine receptor 5 delta32 polymorphism and multiple sclerosis susceptibility.
Immunol Invest. 2014; 43(4):299-311.II

Abstract

OBJECTIVE

The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with multiple sclerosis (MS) susceptibility.

METHODS

Meta-analysis was conducted to determine the association between the CCR5-Δ32 polymorphism and overall incidence of MS as well frequency of relapsing-remitting (RR), primary progressive (PP), and secondary progressive (SP) MS subtypes.

RESULTS

In total, 3869 subjects from eight studies (MS 1666, controls 2203) were considered for meta-analysis. Meta-analysis showed no association between MS and the CCR5-Δ32 allele polymorphism (OR=1.102, 95% CI=0.830-1.462, p=0.502) with a mean frequency of 11.3% in MS patients and 10.4% in controls. Stratification by ethnicity indicated no association between the CCR5-Δ32 allele and MS in Europeans (OR=0.958, 95% CI=0.811-1.132, p=0.618). Meta-analysis by the disease subtype showed no association between RR-MS and the CCR5-Δ32 allele (OR=1.234, 95% CI=0.908-1.677, p=0.178). In addition, no association was found between the CCR5-Δ32 polymorphism and PP or SP-MS.

CONCLUSIONS

Meta-analysis of 3869 subjects indicates a lack of association between the CCR5-Δ32 polymorphism and MS risk in Europeans.

Authors+Show Affiliations

Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine , Seoul , Korea.No affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

24295368

Citation

Song, Gwan Gyu, and Young Ho Lee. "A Meta-analysis of the Relation Between Chemokine Receptor 5 Delta32 Polymorphism and Multiple Sclerosis Susceptibility." Immunological Investigations, vol. 43, no. 4, 2014, pp. 299-311.
Song GG, Lee YH. A Meta-analysis of the relation between chemokine receptor 5 delta32 polymorphism and multiple sclerosis susceptibility. Immunol Invest. 2014;43(4):299-311.
Song, G. G., & Lee, Y. H. (2014). A Meta-analysis of the relation between chemokine receptor 5 delta32 polymorphism and multiple sclerosis susceptibility. Immunological Investigations, 43(4), 299-311. https://doi.org/10.3109/08820139.2013.845204
Song GG, Lee YH. A Meta-analysis of the Relation Between Chemokine Receptor 5 Delta32 Polymorphism and Multiple Sclerosis Susceptibility. Immunol Invest. 2014;43(4):299-311. PubMed PMID: 24295368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Meta-analysis of the relation between chemokine receptor 5 delta32 polymorphism and multiple sclerosis susceptibility. AU - Song,Gwan Gyu, AU - Lee,Young Ho, Y1 - 2013/12/02/ PY - 2013/12/4/entrez PY - 2013/12/4/pubmed PY - 2014/12/15/medline SP - 299 EP - 311 JF - Immunological investigations JO - Immunol. Invest. VL - 43 IS - 4 N2 - OBJECTIVE: The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with multiple sclerosis (MS) susceptibility. METHODS: Meta-analysis was conducted to determine the association between the CCR5-Δ32 polymorphism and overall incidence of MS as well frequency of relapsing-remitting (RR), primary progressive (PP), and secondary progressive (SP) MS subtypes. RESULTS: In total, 3869 subjects from eight studies (MS 1666, controls 2203) were considered for meta-analysis. Meta-analysis showed no association between MS and the CCR5-Δ32 allele polymorphism (OR=1.102, 95% CI=0.830-1.462, p=0.502) with a mean frequency of 11.3% in MS patients and 10.4% in controls. Stratification by ethnicity indicated no association between the CCR5-Δ32 allele and MS in Europeans (OR=0.958, 95% CI=0.811-1.132, p=0.618). Meta-analysis by the disease subtype showed no association between RR-MS and the CCR5-Δ32 allele (OR=1.234, 95% CI=0.908-1.677, p=0.178). In addition, no association was found between the CCR5-Δ32 polymorphism and PP or SP-MS. CONCLUSIONS: Meta-analysis of 3869 subjects indicates a lack of association between the CCR5-Δ32 polymorphism and MS risk in Europeans. SN - 1532-4311 UR - https://www.unboundmedicine.com/medline/citation/24295368/A_Meta_analysis_of_the_relation_between_chemokine_receptor_5_delta32_polymorphism_and_multiple_sclerosis_susceptibility_ L2 - http://www.tandfonline.com/doi/full/10.3109/08820139.2013.845204 DB - PRIME DP - Unbound Medicine ER -